Pawel Olszewski: Biogenesis of the messenger – insights into formation and quality control of yeast mRNP
PhD defence, Tuesday 29 October 2013. Pawel Olszewski.
Messenger ribonucleoprotein particle (mRNP) consists of messenger RNA (mRNA) decorated with proteins of multiple functions, which give it a compact structure, enable export and ensure proper localization and translation. During his studies, Pawel Olszewski investigated the role of mRNP component, polyadenylated RNA-binding protein, Nab2.
Recently a group under Professor Torben Heick Jensen showed that Nab2 is engaged in the quality control process leading to degradation of improperly formed mRNPs. Pawel’s studies provide further evidence for the role in mRNP surveillance and in addition, suggest a novel role in biogenesis of bulk mRNP in yeast cells.
These new research findings contribute to understanding how mRNP is formed. Moreover, results show that mRNP proteins as Nab2 can possess multiple functions in the biogenesis as well as in the quality control of the particle.
The PhD degree was completed at the Department of Molecular Biology and Genetics, Aarhus University and Department of Molecular Biology ad Microbiology, Tufts University, Boston USA.
Time: Tuesday 29 October 2013 at 14.00
Place: Auditorium 223 in building 1110 (Bioinformatics Research Centre), Aarhus University
Title of dissertation: Role of Nab2 in RNA metabolism in Saccharomyces cerevisiae
Contact information: Pawel Olszewski, e-mail: pawelo@mb.au.dk ,
Members of the assessment committee:
Associate professor Francoise Stutz, Department of Cell Biology Sciences III, Universite de Geneve, Switzerland
Associate professor Peter Brodersen, Department of Biology, Bioinformatics, University of Copenhagen, Denmark
Associate professor Anni Hangaard Andersen (chair), Department of Molecular Biology and Genetics, Aarhus University
Main supervisor:
Professor Torben Heick Jensen, Department of Molecular Biology and Genetics, Aarhus University
Co-supervisor:
Professor Claire Moore, Department of Molecular Biology and Microbiology, Tufts University
Language: The PhD dissertation will be defended in English.
The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1521, room 112, 8000 Aarhus C.