Simon Asbjørn Larsen:The discovery of recombinant antibody fragments binding breast cancer tissue
PhD defence, Tuesday 31 March 2015, Simon Asbjørn Larsen
Breast cancer specific antibodies may unravel novel discoveries in biomarkers and aid better stratification of patients.
During his PhD studies, Simon Asbjørn Larsen worked on the selection of recombinant antibody fragments by phage display. A method was developed to perform selections on a minute target area of breast cancer cells in tissue sections. Several of the selected antibody fragments were found to be breast cancer specific by immunohistochemistry experiments.
Further characterization of the selected antibody fragments and their cognate antigens may contribute to our understanding of breast cancer subpopulations and the development of individualized treatment strategies.
The PhD degree was completed at the Department of Molecular Biology and Genetics, Science and Technology, Aarhus University.
Time: Tuesday 31 March 2015 at 11.00
Place: Building 3130, room 303, Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10, 8000 Aarhus C
Title of dissertation: Identification and analysis of cell-specific biomarkers of breast cancer subpopulations by recombinant antibody selection
Contact information: Simon Asbjørn Larsen, SAL@mbg.au.dk
Members of the assessment committee:
Principal Investigator, Ugo Cavallaro, Molecular Medicine Program, European Institute of Oncology, Milano, Italy
Team Leader, Pierre Martineau, Institut de Recherche en Cancérologie de Montpellier
Associate Professor, Ernst-Martin Füchtbauer (chair), Department of Molecular Biology and Genetics, Aarhus University
Main supervisor: Associate Professor, Peter Kristensen, Department of Engineering, Aarhus University
Language: The dissertation will be defended in English
The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1521, room 112, 8000 Aarhus C.