Søren Kløverpris: Study of a network of pregnancy proteins
PhD defence, Tuesday 17 January 2012. Søren Kløverpris.
In the course of his PhD studies, Søren Kløverpris worked on pregnancy-related proteins. During pregnancy, a number of proteins are expressed by the placenta and released into the mother’s blood. One of these is called the proform of eosinophil major basic protein (proMBP), which is complex bound to the proteins angiotensinogen and PAPP-A. These are important components of two biochemical systems that are thought to play an important role in foetal development.
To gain a better understanding of the role of proMBP during pregnancy, Søren Kløverpris analysed the above-mentioned protein complexes in plasma and serum from pregnant women. He also worked with zebrafish as model organisms, and he established the so-called zinc finger nuclease technology in the laboratory. This technology makes it possible to inactivate relevant genes in the fish, which could contribute to establishing the zebrafish as a model organism in the laboratory.
The PhD degree was completed at the Department of Molecular Biology and Genetics, Science and Technology, Aarhus University.
Time: Tuesday 17 January 2012 at 9.00
Place: Lecture Theatre D1 (building 1531, room 113), Department of Mathematics, Aarhus University
Title of dissertation: Dissection of a protein network present in pregnancy plasma and serum
Contact information: Søren Kløverpris, sok@mb.au.dk, +45 8715 4908/5190 3327
Members of the assessment committee:
Professor Michael Bader, Max Delbrück Centre for Molecular Medicine (MDC), Berlin, Germany
Associate Professor Kåre Lehmann Nielsen, Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University
Associate Professor Esben Skipper Sørensen (chair), Department of Molecular Biology and Genetics, Aarhus University
Main supervisor:
Professor Claus Oxvig, Department of Molecular Biology and Genetics, Aarhus University
Language: The dissertation will be defended in English
The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology / GSST, Ny Munkegade 120, building 1521, room 112, 8000 Aarhus C.