Steffen Nyegaard: Milk protein as inhibitor of inflammatory conditions – potential in autoinflammatory diseases
PhD defence, Tuesday 5 March 2013. Steffen Nyegaard.
During his PhD studies, Steffen Nyegaard investigated proteins from milk and their impact on intestinal homeostasis, as well as their regulatory effect on the inflammatory response. An increasing number of cases of inflammatory bowel disease (IBD) has been registered in Western countries. Research has pointed towards dysregulation in the immune system, genetic disposition and environmental factors as important causes of these diseases with subsequent increased inflammation. The consequences of intestinal inflammation often involve lifelong treatment, malnutrition and surgical intervention.
Steffen Nyegaard demonstrated the anti-inflammatory effect of the milk protein lactadherin, and this new knowledge could have important implications in the treatment of autoimmune diseases such as IBD. He also showed how different milk proteins affect the rate of intestinal cell migration and thereby the speed of the healing process.
The PhD degree was completed at the Department of Molecular Biology and Genetics, Science and Technology, Aarhus University.
Time: Tuesday 5 March 2013 at 13.00
Place: Meeting room A, building 3120, Aarhus University
Title of dissertation: Modulation of intestinal homeostasis by lactadherin
Contact information: Steffen Nyegaard, stny@mb.au.dk, +45 2278 7676
Members of the assessment committee:
Professor Koen Dewettinck, Department of Food Safety and Food Quality, Ghent University, Belgium
Associate Professor Daniel Wüstner, Department of Biochemistry and Molecular Biology, University of Southern Denmark
Professor Claus Oxvig (chair), Department of Molecular Biology and Genetics, Aarhus University
Main supervisor:
Associate Professor Jan Trige Rasmussen, Department of Molecular Biology and Genetics, Aarhus University
Language: The dissertation will be defended in English
The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1521, room 112, 8000 Aarhus C.