Lotte D’Andrea Markert: Topographical signals can control cellular activity

During the course of her PhD studies, Lotte D’Andrea Markert carried out research into how topographic surfaces affect the behaviour of mammalian cells. The organisation of mammalian tissue is carried out in topographical signals that control cellular activity and contribute to the controlled state or development characteristic of healthy organisms.

Lotte D’Andrea Markert studied the way in which systematic variations in the dimensions of geometrically defined microtopographs could be read off in the structural organisation of the cells and activation of biochemical signals. The results of her studies show that topographical signals can be used to tune cellular activity. This emphasises that it is possible to optimise the topography of biomaterials for application in implants or the formation of new tissue.

The PhD degree was completed at the Interdisciplinary Nanoscience Centre (iNANO), Science and Technology, Aarhus University.

Time: Monday 12 March 2012 at 10.00
Place: Lecture Theatre, building 1523, room 323, Department of Physics and Astronomy, Aarhus University
Title of dissertation: Cellular responses to microtopographical cues
Contact information: Lotte D’Andrea Markert, lm@mb.au.dk
Members of the assessment committee:
Associate Professor Jan de Boer, Institute for Biomedical Technology and Technical Medicine, University of Twente, the Netherlands
Associate Professor Hanne Cathrine Bisgaard, Department of Cellular and Molecular Medicine, University of Copenhagen
Associate Professor Duncan Sutherland (chair), iNANO, Aarhus University
Main supervisor:
Professor Finn Skou Pedersen, iNANO and Department of Molecular Biology and Genetics, Aarhus University
Language: The dissertation will be defended in English

The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology / GSST, Ny Munkegade 120, building 1521, room 112, 8000 Aarhus C.