During her PhD studies, Josefine Lorentzen studied the proteins in human complement system. The complement system is an important part of the innate immunity and protects our body against infections, but over activation has been attributed a role in the development of autoimmune and neurological diseases. Josefine Lorentzen studied how the complement receptor 3 recognises its ligands and how this leads to structural changes in the receptor.

The new research findings contribute to the understanding of ligand recognition by complement receptor 3 and the structural changes that the receptor undergoes.

The PhD study was completed at Department of Molecular Biology and Genetics, Faculty of Natural Sciences, Aarhus University.

This summary was prepared by the PhD student.

Time: Thursday, 26 October 2023 at 14:00
Place: Faculty Club (1870-816)
Title of PhD thesis: INVESTIGATING THE FORMATION, INHIBITION AND RECOGNITION OF COMPLEMENT C3 ACTIVATION PRODUCTS

Contact information: Josefine Lorentzen, e-mail: jl@mbg.au.dk, tel.: +45 28687471

Members of the assessment committee:
Professor Phoebe L. Stewart, Department of Pharmacology, Case Western Reserve University, USA

Professor Susanna Carola Fagerholm, Research Program of Molecular and Integrative Biosciences, University of Helsinki, Finland

Senior Researcher Jan Trige Rasmussen (chair), Department of Molecular Biology and Genetics, Aarhus University, Denmark

Main supervisor:
Professor Gregers Rom Andersen, Department of Molecular Biology and Genetics, Aarhus University, Denmark

Language: The PhD dissertation will be defended in English

The defence is public.
The PhD thesis is available for reading at the Graduate School of Natural Sciences/GSNS, Jens Baggesens Vej 53, building 5221, 8200 Aarhus N.