During his PhD studies, Patrik Polák investigated proteins involved in nuclear RNA decay facilitated by the RNA exosome. Human cells produce a wide variety of RNAs that must be accurately sorted into different productive and destructive pathways. Patrik Polák studied the zinc-finger protein ZFC3H1, a central factor for directing nuclear polyadenylated RNAs for decay and investigated how it is recruited to different subsets of its RNA targets. The new research findings help us better understand the molecular sorting mechanisms of nuclear polyadenylated RNAs and their recruitment for degradation.

The PhD study was completed at the Department of Molecular Biology and Genetics, Faculty of Natural Sciences, Aarhus University.

This summary was prepared by the PhD student.

Time: Friday, 4 February 2022 at 13:15

Place: The PhD defence will be held online. To receive a link to the event, please send an e-mail to Jan Trige Rasmussen, jatr@mbg.au.dk

Title of PhD thesis: Mutational analysis of the RNA exosome cofactor ZFC3H1

Contact information: Patrik Polák, e-mail: patrik.polak@mbg.au.dk, tel.: +421 915229325

Members of the assessment committee:
Professor Elmar Wahle, Institute of Biochemistry and Biotechnology, University of Halle, Germany
Professor Georg Stoecklin, Medical Faculty Mannheim, Heidelberg University, Germany
Senior Researcher Jan Trige Rasmussen (chairman), Department of Molecular Biology and Genetics, Aarhus University, Denmark

Main supervisor:
Professor Torben Heick Jensen, Department of Molecular Biology and Genetics, Aarhus University, Denmark

Language: The PhD dissertation will be defended in English

The defence is public.

The PhD thesis is available for reading at the Graduate School of Natural Sciences/GSNS, Katrinebjergvej 89F, building 5132, 8200 Aarhus N.