Understanding how the “heart” of the plant works may lead to protecting plants from pathogens
Researchers at Aarhus University have discovered the secrets behind how plants move sugar using a protein called the SUC transporter. This breakthrough solves a long-standing mystery of the plant 'heart' and sheds new light on how plants defend themselves from pests. The discovery published in Nature Plants is the result of over five years of research by a talented team of scientists.
Plants, like humans, need to move sugar and other nutrients around their bodies to power their growth. But unlike humans, they do not have a heart to pump these vital nutrients. Instead, they use an amazing molecular pump mechanism that scientists have been studying for decades since its discovery more than 30 years ago.
Now, a team of researchers led by Associate Professor Bjørn P. Pedersen at the Department of Molecular Biology and Genetics at Aarhus University has made a groundbreaking discovery about one of the most important components of this pump mechanism: the SUC transporter. This molecule is like a microscopic sugar delivery truck that actively loads a type of sugar called sucrose (tabletop sugar) into the plant's "veins," which are called the phloem.
Until now, scientists have struggled to understand exactly how this transporter works. But the team's new research has uncovered the secrets behind how the SUC transporter recognizes sucrose and how it uses acid to power its sugar delivery.
“This discovery is a breakthrough because it finally solves a long-standing mystery: how plants are able to sustain the loading of sucrose into the “veins” and create the turgor pressure that generates the flow of all nutrients in the phloem,” says Bjørn P Pedersen. “This is like the plant's "heart" and it's critical for the plant's survival and growth.”
The team's work also shed new light on how plants defend themselves from pests. When plants are under attack, pests try to steal the sugar in the phloem. But the SUC transporter is essential for the plant's defense capabilities, and understanding how it works could help us protect plants from harmful bugs in the future.
The discovery is the result of five years research
This research is the result of more than five years of hard work by a talented team of scientists, including lead author Laust Bavnhøj and Jan Driller, as well as Lorena Zuzic, Amanda Stange, and Professor Birgit Schiøtt from the Department of Chemistry. It is a huge step forward in our understanding of how plants work at the molecular level.
“I am absolutely thrilled to finally publish the first-ever structure of the SUC transporter, which allowed us to visualize transporter function and together with our biochemical data illuminate the long-sought molecular mechanism behind sucrose transport,” says Laust Bavnhøj, “starting this project from scratch back in 2018 has been a long and challenging journey.”
The results have been published in the international journal Nature Plants: https://doi.org/10.1038/s41477-023-01421-0
For further information, please contact
Associate Professor Bjørn Panyella Pedersen
Department of Molecular Biology and Genetics
Aarhus University, Denmark
email@example.com – mobile +45 29723499
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CONTENT AND PURPOSE
This work was supported by grants from the Novo Nordisk Foundation (NNF18OC0032608 and NF20OC0065431) and the Lundbeck Foundation (R346-2020-1944) to B.S. This project received funding from the European Research Council under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 101000936) to B.P.P.
Conflict of interest
Link to the scientific paper
Laust Bavnhøj, Jan Heiner Driller, Lorena Zuzic, Amanda Dyrholm Stange, Birgit Schiøtt & Bjørn Panyella Pedersen
Structure and sucrose binding mechanism of the plant SUC1 sucrose transporter