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Department of Molecular Biology and Genetics

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Latest peer-reviewed publications at MBG

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Displaying results 3901 to 99 out of 99

Peer-reviewed publications at MBG - all years

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Andersen, M. Ø., Nygaard, J. V., Burns, J. S., Raarup, M. K., Nyengaard, J. R., Bünger, C., Besenbacher, F., Howard, K. A., Kassem, M. & Kjems, J. (2010). siRNA nanoparticle functionalization of nanostructured scaffolds enables controlled multilineage differentiation of stem cells. Molecular Therapy, 18(11), 2018-2027. https://doi.org/10.1038/mt.2010.166

Laursen, N. S., Gordon, N., Lorenz, N., Jackson, N., Wines, B., Spillner, E., Christensen, J. B., Jensen, M., Fredslund, F., Bjerre, M., Sottrup-Jensen, L., Fraser, J. & Andersen, G. R. (2010). Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus. Proceedings of the National Academy of Sciences (PNAS), 107(8), 3681-3686.

Ekberg, K., Pedersen, B. P., Sørensen, D. M., Veierskov, B., Nissen, P., Palmgren, M. & Buch-Pedersen, M. J. (2010). Structural identification of cation binding pockets in the plasma membrane proton pump. Proceedings of the National Academy of Sciences (PNAS), 107, 21400-21405.

Ekberg, K., Pedersen, B. P., Sørensen, D. M., Nielsen, A. K., Veierskov, B., Nissen, P., Palmgren, M. G. & Buch-Pedersen, M. J. (2010). Structural identification of cation binding pockets in the plasma membrane proton pump. Proceedings of the National Academy of Sciences (PNAS), 107(50), 21400-5. https://doi.org/10.1073/pnas.1010416107

Pedersen, B. P., Morth, J. P. & Nissen, P. (2010). Structure determination using poorly diffracting membrane protein crystals - Lessons from the H+ and Na+,K+-ATPases. Acta Crystallographica Section D: Biological Crystallography, 66, 309-313.

Oliveira, C. L. P. D., Jensen, S. J., Jørgensen, H. L., Knudsen, B., Tordrup, D. P., Oteri, F., Falconi, M., Koch, J. E., Desideri, A., Pedersen, J. S., Knudsen, B. R. & Andersen, F. F. (2010). Structure of nano-Scale Truncated Octahedral DNA Cages: Variation of Single-stranded Linker Regions and Influence on Assembly Yields. A C S Nano, 4.

Dagnæs-Hansen, F., Moser, J. M., Schmitt-John, T. & Aarup, M. (2010). Sudden death in lactating inbred mice. Clostridium perfringens enteropathy. Lab Animal.

Buttenschøn, H. N., Foldager, L., Zacharov, T. F., Olsen, I. M. L., Deleuran, T., Nyegaard, M., Hansen, M. M., Kallunki, P., Christensen, K. V., Blackwood, D. H., Muir, W. J., Straarup, S. E., Als, T. D., Nordentoft, M., Børglum, A. & Mors, O. (2010). Support for a bipolar affective disorder susceptibility locus on chromosome 12q24.3. Psychiatric Genetics, 20(3), 93-101. https://doi.org/10.1097/YPG.0b013e32833a2066

Xu, W., Wang, J.-G., Jacobsen, M. F., Mura, M., Yu, M., Kelly, R. E. A., Meng, Q.-Q., Lægsgaard, E., Stensgaard, I., Linderoth, T. R., Kjems, J., Kantorovich, L. N., Gothelf, K. V. & Besenbacher, F. (2010). Supramolecular porous network formed by molecular recognition between chemically modified nucleobases guanine and cytosine. Angewandte Chemie International Edition, 49(49), 9373-7. https://doi.org/10.1002/anie.201003390

Otzen, D. (2010). Surfactants and alcohols as inducers of protein amyloid: aggregation chaperones or membrane simulators? Lipids and membranes in amyloid diseases.

Rattan, S. (2010). Synthesis, modification and turnover of proteins during aging. Advances in Experimental Medicine and Biology, 694, 1-13.

Rattan, S. (2010). Targeting the age-related occurrence, removal, and accumulation of molecular damage by hormesis. New York Academy of Sciences. Annals, 1197, 28-32.

Rattan, S. & Deva, T. (2010). Testing the hormetic nature of homeopathic interventions through stress response pathways. Human & Experimental Toxicology, 29(7), 551-554.

Schierup, M. H. & Wiuf, C. H. (2010). The coalescent in bacterial populations. In D. A. Robinson, D. Falush & E. J. Feil (Eds.), Bacterial population genetics in infectious disease (pp. 3-19). Wiley-Blackwell.

Petersen, S. V., Thøgersen, I., Valnickova, Z., Nielsen, M. S., Petersen, J. S., Poulsen, E. T., Jacobsen, C., Oury, T. D., Moestrup, S. K., Crapo, J. D., Nielsen, N. C., Kristensen, T. & Enghild, J. J. (2010). The concentration of extracellular superoxide dismutase in plasma is maintained by LRP-mediated endocytosis. Free Radical Biology & Medicine, 49(5), 894-9. https://doi.org/10.1016/j.freeradbiomed.2010.06.019

Tomecki, R., Kristiansen, M. S., Lykke-Andersen, S., Chlebowski, A., Larsen, K. M., Szczesny, R. J., Drazkowska, K., Pastula, A., Andersen, J. S., Stepien, P. P., Dziembowski, A. & Jensen, T. H. (2010). The human core exosome associates with differentially localized processive ribonucleases: hDIS3 and hDIS3L. EMBO Journal, 29(14), 2342-2357.

Nielsen, S. B., Wilhelm, K., Vad, B., Schleucher, J., Morozova-Roche, L. A. & Otzen, D. (2010). The interaction of equine lysozyme:oleic acid complexes with lipid membranes suggests a cargo off-loading mechanism. Journal of Molecular Biology, 398(2), 351-61. https://doi.org/10.1016/j.jmb.2010.03.012

Juul, T., Malolepszy, A., Dybkaer, K., Kidmose, R., Rasmussen, J. T., Andersen, G. R., Johnsen, H. E., Jørgensen, J.-E. & Andersen, S. U. (2010). The in vivo toxicity of hydroxyurea depends on its direct target catalase. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.M110.103564

Madsen, L. H., Tirichine, L., Jurkiewicz, A. M., Sullivan, J. T., Heckmann, A. B. L., Bek, A. S., Ronson, C., James, E. K. & Stougaard, J. (2010). The molecular network governing nodule organogenesis and infection in the model legume Lotus japonicus. Nature Communications, 1(1).

Sanggaard, K. W., Scavenius, C., Rasmussen, A. J., Wisniewski, H.-G., Thøgersen, I. & Enghild, J. J. (2010). The TSG-6/HC2-mediated transfer is a dynamic process shuffling heavy chains between glycosaminoglycans. Journal of Biological Chemistry, 285(29), 21988-93. https://doi.org/10.1074/jbc.M109.041046

Kjeldsen, E., Hübner, G. M., Tordrup, D. P., Knudsen, B. R. & Andersen, F. F. (2010). Topoisomerase I Deficiency Results in Chromosomal Alterations in Cervical Cancer Cells. Anticancer Research, 30, 3257-3265.

Laursen, M. B., Pakula, M. M., Gao, S., Fluiter, K., Mook, O. R., Baas, F., Langklaer, N., Wengel, S. L., Wengel, J., Kjems, J. & Bramsen, J. B. (2010). Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo. Molecular BioSystems, 6(5), 862-70. https://doi.org/10.1039/b918869j

Haile, J., Froese, D. G., MacPhee, R. D. E., Roberts, R. G., Arnold, L. J., Reyes, A. V., Rasmussen, M., Nielsen, R., Brook, B. W., Robinson, S., Demuro, M., Gilbert, M. T. P., Munch, K., Austin, J. J., Cooper, A., Barnes, I., Möller, P. & Willerslev, E. (2009). Ancient DNA reveals late survival of mammoth and horse in interior Alaska. Proceedings of the National Academy of Sciences (PNAS), 106(52), 22352-22357. https://doi.org/10.1073/pnas.0912510106

Kong, A., Steinthorsdottir, V., Masson, G., Thorleifsson, G., Sulem, P., Besenbacher, S., Jonasdottir, A., Sigurdsson, A., Kristinsson, K. T., Jonasdottir, A., Frigge, M. L., Gylfason, A., Olason, P. I., Gudjonsson, S. A., Sverrisson, S., Stacey, S. N., Sigurgeirsson, B., Benediktsdottir, K. R., Sigurdsson, H. ... Lauritzen, T. (2009). Parental origin of sequence variants associated with complex diseases. Nature, 462(7275), 868-74. https://doi.org/10.1038/nature08625

Neubauer, C., Gao, Y.-G., Andersen, K. R., Dunham, C. M., Kelley, A. C., Hentschel, J., Gerdes, K., Ramakrishnan, V. & Brodersen, D. E. (2009). The structural basis for mRNA recognition and cleavage by the ribosome-dependent endonuclease RelE. Cell, 139(6), 1084-1095. https://doi.org/10.1016/j.cell.2009.11.015

Watson-Haigh, N. S., Kadarmideen, H. N. & Reverter, A. (2009). PCIT: An R package for weighted gene co-expression networks based on partial correlation and information theory approaches. Bioinformatics, 26(3), 411-413. https://doi.org/10.1093/bioinformatics/btp674

Jahn, K., Nielsen, M. M., Olsen, E. M., Mohammadzadegan, R., Andersen, E. S., Gothelf, K. V. & Kjems, J. (2009). Site-specific labeling of long HIV-1 RNA using DNA templated chemistry. 84-88. Paper presented at 6th Annual Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2009, Snowbird, UT, United States.

Kjær, K. H., Poulsen, J. B., Reitamm, T., Saby, E., Martensen, P. M., Kelve, M. & Justesen, J. (2009). Evolution of the 2'-5'-Oligoadenylate Synthetase family in eukaryotes and bacteria. Journal of Molecular Evolution, 69(6), 612-624. https://doi.org/10.1007/s00239-009-9299-1

Fiorani, P., Tesauro, C., Mancini, G., Chillemi, G., D'Annessa, I., Graziani, G., Tentori, L., Muzi, A. & Desideri, A. (2009). Evidence of the crucial role of the linker domain on the catalytic activity of human topoisomerase I by experimental and simulative characterization of the Lys681Ala mutant. Nucleic Acids Research, 37(20), 6849-6858. https://doi.org/10.1093/nar/gkp669

Bonneau, F., Basquin, J., Ebert, J., Lorentzen, E. & Conti, E. (2009). The yeast exosome functions as a macromolecular cage to channel RNA substrates for degradation. Cell, 139(3), 547-559.

Goodall, N., Kisiswa, L., Prashar, A., Faulkner, S., Tokarczuk, P., Singh, K., Erichsen, J. T., Guggenheim, J., Halfter, W. & Wride, M. A. (2009). 3-Dimensional modelling of chick embryo eye development and growth using high resolution magnetic resonance imaging. Experimental Eye Research, 89(4), 511-521. https://doi.org/10.1016/j.exer.2009.05.014

Karacaören, B., Kadarmideen, H., Janss, L. LG. & Jaffrecic, F. (2009). Investigations on Functional Traits in Dairy Cattle: Phenotypic and Genetic Analysis of Functional Traits in Dairy cattle under Experimental Management System. VDM Verlag. https://www.amazon.com/Investigations-Functional-Traits-Dairy-Cattle/dp/3639189779

Mittag, T., Nielsen, N. C., Otzen, D. & Skrydstrup, T. (2009). Synthesis of a Ketomethylene Isostere of the Fibrillating Peptide SNNFGAILSS. Journal of Organic Chemistry, 74, 7955-7957.

Malmström, J., Shipovskov, S., Christensen, B., Sørensen, E. S., Kingshott, P. & Sutherland, D. (2009). Adsorption and enzymatic cleavage of osteopontin at interfaces with different surface chemistries. Biointerphases, 4(3), 47-55. https://doi.org/10.1116/1.3187529

Bøtkjær, K. A., Byszuk, A., Andersen, L. M., Christensen, A., Andreasen, P. & Blouse, G. (2009). Non-proteolytic induction of catalytic activity into the single-chain form of urokinase-type plasminogen activator by dipeptides. Biochemistry, 48(40), 9606-9617.

Høgslund, N., Radutoiu, S., Krusell, L., Voroshilova, V., Hannah, M. A., Goffard, N., Sanchez, D. H., Lippold, F., Ott, T., Sato, S., Tabata, S., Liboriussen, P., Lohmann, G. V., Schauser, L., Weiller, G. F., Udvardi, M. K. & Stougaard, J. (2009). Dissection of symbiosis and organ development by integrated transcriptome analysis of lotus japonicus mutant and wild-type plants. PLoS One, 4(8), e6556. https://doi.org/10.1371/journal.pone.0006556

Laursen, L. S., Chan, C. W. & ffrench-Constant, C. (2009). An integrin-contactin complex regulates CNS myelination by differential Fyn phosphorylation. The Journal of neuroscience, 29(29), 9174-85. https://doi.org/10.1523/JNEUROSCI.5942-08.2009

Jensen, J. K., Dolmer, K., Schar, C. & Gettins, P. G. W. (2009). Receptor-associated protein (RAP) has two high-affinity binding sites for the low-density lipoprotein receptor-related protein (LRP): consequences for the chaperone functions of RAP. Biochemical Journal, 421(2), 273-82. https://doi.org/10.1042/BJ20090175

Jensen, J. K., Dolmer, K. & Gettins, P. G. W. (2009). Specificity of binding of the low density lipoprotein receptor-related protein to different conformational states of the clade E serpins plasminogen activator inhibitor-1 and proteinase nexin-1. Journal of Biological Chemistry, 284(27), 17989-97. https://doi.org/10.1074/jbc.M109.009530

Staunstrup, N. H., Moldt, B., Mátés, L., Villesen, P., Jakobsen, M., Ivics, Z., Izsvák, Z. & Mikkelsen, J. G. (2009). Hybrid Lentivirus-transposon Vectors With a Random Integration Profile in Human Cells. Molecular Therapy, 17(7), 1205-14. https://doi.org/10.1038/mt.2009.10

Castelli, S., Campagna, A., Vassallo, O., Tesauro, C., Fiorani, P., Tagliatesta, P., Oteri, F., Falconi, M., Majumder, H. K. & Desideri, A. (2009). Conjugated eicosapentaenoic acid inhibits human topoisomerase IB with a mechanism different from camptothecin. Archives of Biochemistry and Biophysics, 486(2), 103-110. https://doi.org/10.1016/j.abb.2009.04.007

Geatrell, J. C., Mui (Iryn) Gan, P., Mansergh, F. C., Kisiswa, L., Jarrin, M., Williams, L. A., Evans, M. J., Boulton, M. E. & Wride, M. A. (2009). Apoptosis gene profiling reveals spatio-temporal regulated expression of the p53/Mdm2 pathway during lens development. Experimental Eye Research, 88(6), 1137-1151. https://doi.org/10.1016/j.exer.2009.01.020

Andersen, K. R., Jonstrup, A. T., Van, L. B. & Brodersen, D. E. (2009). The activity and selectivity of fission yeast Pop2p are affected by a high affinity for Zn2+ and Mn2+ in the active site. RNA, 15(5), 850-61. https://doi.org/10.1261/rna.1489409

Thomsen, P. F., Elias, S., Gilbert, M. T. P., Haile, J., Munch, K., Kuzmina, S., Froese, D. G., Sher, A., Holdaway, R. N. & Willerslev, E. (2009). Non-destructive sampling of ancient insect DNA. PLoS One, 4(4), Article e5048. https://doi.org/10.1371/journal.pone.0005048

Blouse, G. E., Dupont, D. M., Schar, C. R., Jensen, J. K., Minor, K. H., Anagli, J. Y., Gårdsvoll, H., Ploug, M., Peterson, C. B. & Andreasen, P. A. (2009). Interactions of plasminogen activator inhibitor-1 with vitronectin involve an extensive binding surface and induce mutual conformational rearrangements. Biochemistry, 48(8), 1723-35. https://doi.org/10.1021/bi8017015

Muftuoglu, M., Souza-Pinto, NC., Dogan, A., Aamann, M. A. D., Stevnsner, T. V., Rybanska, I., Kirkali, G., Dizdaroglu, M. & Bohr, V. (2009). Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase. Journal of Biological Chemistry, 284(14), 9270-9279. https://doi.org/10.1074/jbc.M807006200

Colón, E., Shytuhina, A., Cowman, M. K., Band, P. A., Sanggaard, K. W., Enghild, J. J. & Wisniewski, H.-G. (2009). Transfer of inter-alpha-inhibitor heavy chains to hyaluronan by surface-linked hyaluronan-TSG-6 complexes. Journal of Biological Chemistry, 284(4), 2320-2231. https://doi.org/10.1074/jbc.M807183200

Huynh, T. H. V., Mantel, M., Mikkelsen, K., Lindhardt, A. T., Nielsen, N. C., Otzen, D. & Skrydstrup, T. (2009). A Versatile Approach to β-Amyloid Fibril-Binding Compounds Exploiting the Shirakawa/Hayashi Protocol for trans-Alkene Synthesis. Organic Letters, 11, 999-1002.

Eberle, A., Lykke-Andersen, S., Mühlemann, O. & Jensen, T. H. (2009). SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells. Nature Structural and Molecular Biology, 16(1), 49-55.

Smagur, J., Guzik, K., Magiera, L., Bzowska, M., Gruca, M., Thøgersen, I. B., Enghild, J. J. & Potempa, J. (2009). A new pathway of staphylococcal pathogenesis: Apoptosis-like death induced by staphopain B in human neutrophils and monocytes. Journal of Innate Immunity, 1(2), 98-108. https://doi.org/10.1159/000181014

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Lisbeth Heilesen