Peer-reviewed articles

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Peer-reviewed publications at MBG - 2025

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Garde, C., Pavlidis, M. A., Garces, P., Lange, E. J., Ramarathinam, S. H., Sokač, M., Pandey, K., Faridi, P., Ahrenfeldt, J., Chung, S., Friis, S., Kleine-Kohlbrecher, D., Birkbak, N. J., Kringelum, J. V., Rønø, B., Purcell, A. W. & Trolle, T. (2025). Endogenous viral elements constitute a complementary source of antigens for personalized cancer vaccines. NPJ vaccines, 10(1), Article 54. https://doi.org/10.1038/s41541-025-01107-y

Rasmussen, C. L. M., Frederiksen, S. F., Heegaard, C. W., Thomsen, M. S., Hede, E., Laczek, B., Körbelin, J., Wüstner, D., Thomsen, L. B., Schwaninger, M., Jensen, O. N., Moos, T. & Burkhart, A. (2025). Endothelial and neuronal engagement by AAV-BR1 gene therapy alleviates neurological symptoms and lipid deposition in a mouse model of Niemann-Pick type C2. Fluids and Barriers of the CNS, 22(1), Article 13. https://doi.org/10.1186/s12987-025-00621-4

Qin, Q., Wei, P., Usman, S., Ahamefule, C. S., Jin, C., Wang, B., Yan, K., van Aalten, D. M. F. & Fang, W. (2025). Gfa1 (glutamine fructose-6-phosphate aminotransferase) is essential for Aspergillus fumigatus growth and virulence. BMC Biology, 23(1), Article 80. https://doi.org/10.1186/s12915-025-02184-0

Bryzek, D., Gasiorek, A., Kowalczyk, D., Santocki, M., Ciaston, I., Dobosz, E., Kolaczkowska, E., Kjøge, K., Kantyka, T., Lech, M., Potempa, B., Enghild, J. J., Potempa, J. & Koziel, J. (2025). Non-classical neutrophil extracellular traps induced by PAR2-signaling proteases. Cell Death & Disease, 16(1), 109. Article 109. https://doi.org/10.1038/s41419-025-07428-z

Thorsen, T. S., Kulkarni, Y., Sykes, D. A., Bøggild, A., Drace, T., Hompluem, P., Iliopoulos-Tsoutsouvas, C., Nikas, S. P., Daver, H., Makriyannis, A., Nissen, P., Gajhede, M., Veprintsev, D. B., Boesen, T., Kastrup, J. S. & Gloriam, D. E. (2025). Structural basis of THC analog activity at the Cannabinoid 1 receptor. Nature Communications, 16(1), Article 486. https://doi.org/10.1038/s41467-024-55808-4

Mirab, F., Pirhaghi, M., Otzen, D. E. & Saboury, A. A. (2025). Parkinson's disease and gut microbiota metabolites: The dual impact of vitamins and functional amyloids. B B A - Molecular Basis of Disease, 1871(6), Article 167862. https://doi.org/10.1016/j.bbadis.2025.167862

Nowak, J. S., Olesen, S., Tian, P., Bærentsen, R. L., Brodersen, D. E. & Otzen, D. E. (2025). Role of electrostatics in cold adaptation: A comparative study of eury- and stenopsychrophilic triose phosphate isomerase. B B A - Proteins and Proteomics, 1873(4), Article 141072. https://doi.org/10.1016/j.bbapap.2025.141072

Thomsen, M. E., Bennike, T. B., Christiansen, G., Emmersen, J., Laursen, N. S., Zarantonello, A., Andersen, G. R., Liu, L., Dueholm, M. K. D., Opstrup, K. V., Stensballe, A. & Birkelund, S. (2025). Differences in complement activation of serum-resistant and serum-sensitive Klebsiella pneumoniae isolates. Molecular immunology, 183, 274-285. https://doi.org/10.1016/j.molimm.2025.05.014

Henches, L., Kim, J., Yang, Z., Rubinacci, S., Pires, G., Albiñana, C., Boetto, C., Julienne, H., Frouin, A., Auvergne, A., Suzuki, Y., Djebali, S., Delaneau, O., Ganna, A., Vilhjálmsson, B., Privé, F. & Aschard, H. (2025). Polygenic risk score prediction accuracy convergence. Human Genetics and Genomics Advances, 6(3), Article 100457. https://doi.org/10.1016/j.xhgg.2025.100457

Fabbrizio, P., Baindoor, S., Margotta, C., Su, J., Morrissey, E. P., Woods, I., Hogg, M. C., Vianello, S., Venø, M. T., Kjems, J., Sorarù, G., Bendotti, C., Prehn, J. H. M. & Nardo, G. (2025). Protective role of Angiogenin in muscle regeneration in amyotrophic lateral sclerosis: Diagnostic and therapeutic implications. Brain Pathology, 35(4), Article e13328. https://doi.org/10.1111/bpa.13328

Almeida, A. V., Jensen, K. T., Harwood, S. L., Jørgensen, M. H., Nielsen, N. S., Thøgersen, I. B., Enghild, J. J. & Andersen, G. R. (2025). Three cryo-EM structures of CD109 reveal its mechanism of protease inhibition. Cell Reports, 44(6), Article 115787. https://doi.org/10.1016/j.celrep.2025.115787

Jin, Z., Olsen, W. P., Mörman, C., Leppert, A., Kumar, R., Møllebjerg, A., Nielsen, L. G., Moshynets, O. V., Frasinyuk, M. S., Elosua, J. Y., Ferreira, D., Abelein, A., Landreh, M., Knight, S. D., Johansson, J., Otzen, D. E. & Chen, G. (2025). Helicobacter pylori CagA protein is a potent and broad-spectrum amyloid inhibitor. Science Advances, 11(24), Article eads7525. https://doi.org/10.1126/sciadv.ads7525

Garcia-Erill, G., Liu, S., Le, M. D., Hurley, M. M., Nguyen, H. D., Nguyen, D. Q., Nguyen, D. H., Santander, C. G., Sánchez Barreiro, F., Gomes Martins, N. F., Hanghøj, K., Salleh, F. M., Ramos-Madrigal, J., Wang, X., Sinding, M. H. S., Morales, H. E., Stæger, F. F., Wilkinson, N., Meng, G. ... Heller, R. (2025). Genomes of critically endangered saola are shaped by population structure and purging. Cell, 188(12), 3102-3116.e22. https://doi.org/10.1016/j.cell.2025.03.040

Peña Díaz, S., Zhang, Z., Jiang, Y., Daugberg, A. O. H., López Hernández, M., Nielsen, J., Dueholm, M. K. D., Dong, MD., Pedersen, J. S., Otzen, D. E. & Wang, H. (2025). Natural Design of a Stabilized Cross-β Fold: Structure of the FuA FapC from Pseudomonas Sp. UK4 Reveals a Critical Role for Stacking of Imperfect Repeats. Advanced Materials. Advance online publication. https://doi.org/10.1002/adma.202505503

Kristoffersen, E. L., McRae, E. K. S., Sørensen, N. R., Holliger, P. & Andersen, E. S. (2025). Roles of dimeric intermediates in RNA-catalyzed rolling circle synthesis. Nucleic Acids Research, 53(11). https://doi.org/10.1093/nar/gkaf057

Paasch, T. P., Olesen, M. T. J., García-Rodríguez, J. L., Assmus, A. M., Fenton, R. A., Kjems, J., Hager, H. & Kristensen, L. S. (2025). ciRS-7 expression is epigenetically regulated in cancer cells across human adenocarcinomas. PLOS Genetics, 21(6), Article e1011726. https://doi.org/10.1371/journal.pgen.1011726

Horsdal, H. T., Albiñana, C., Zhu, Z., Boelt, S. G., Borbye-Lorenzen, N., Cohen, A. S., Skogstrand, K., Melgaard, L., MacSween, N. J., Thorbek, M. J., Plana-Ripoll, O., Petersen, L. V., Bulik, C. M., Børglum, A. D., Mors, O., Nordentoft, M., Werge, T., Moen, G.-H., D'Urso, S. ... McGrath, J. J. (2025). Convergent evidence linking neonatal vitamin D status and risk of neurodevelopmental disorders: a Danish case-cohort study. The Lancet Psychiatry, 12(6), 410-420. https://doi.org/10.1016/S2215-0366(25)00099-9

Cabrejas-Olalla, A., Jørgensen, F. G., Cheng, J. Y., Kjærgaard, P. C., Schierup, M. H., Mailund, T. & Athanasiadis, G. (2025). Genetic predictions of eye and hair colour in the Danish population. Forensic Science International: Genetics, 78, Article 103267. https://doi.org/10.1016/j.fsigen.2025.103267

Andersen, H. H., Andersen, M. K., Bossow, K. A., Vestergaard, A. L., Bor, P. & Larsen, A. (2025). High-dose vitamin D supplementation in pregnancy ameliorates obesity-induced increase in maternal IL-1β level without affecting obesity-induced increase in IL-6 and MCP. The Journal of Steroid Biochemistry and Molecular Biology, 250, Article 106742. https://doi.org/10.1016/j.jsbmb.2025.106742

Otzen, D. E., Peña-Díaz, S., Widmann, J., Daugberg, A. O. H., Zhang, Z., Jiang, Y., Mittal, C., Dueholm, M. K. D., Louros, N., Wang, H. & Javed, I. (2025). Interactions between pathological and functional amyloid: A match made in Heaven or Hell? Molecular Aspects of Medicine, 103, 101351. Article 101351. https://doi.org/10.1016/j.mam.2025.101351

Staehr, C., Login, H., Melnikova, E., Bakun, M., Ziemlinska, E., Kisiswa, L., Berenji Ardestani, S., Nolte, S. S., Beck, H. C., Hansen, L. M. B., Postnov, D., Verkhratsky, A., Malik, A. R., Nykjær, A. & Matchkov, V. (2025). SorCS2 Is Important for Astrocytic Function in Neurovascular Signaling. Acta Physiologica (Print), 241(6), Article e70052. https://doi.org/10.1111/apha.70052

McLain, A., Kowalczyk, A., Baran-Rachwalska, P., Sutera, F. M., Robertson, L. J., Nielsen, N. S., Enghild, J. J., Cobice, D., Bonelli, F., Barbaro, V., Ferrari, S., Patterson, B., Moore, L., Marshall, J., Nesbit, M. A. & Moore, T. (2025). TGFBI R124H mutant allele silencing in granular corneal dystrophy type 2 using topical siRNA delivery. Journal of Controlled Release, 382, Article 113681. https://doi.org/10.1016/j.jconrel.2025.113681

Kjær, A., Kristjánsdóttir, N., Juul, R. I., Nordentoft, I., Birkenkamp-Demtröder, K., Ahrenfeldt, J., Strandgaard, T., Radif, D., Hodgson, D., Abbosh, C., Aerts, H. J. W. L., Agerbæk, M., Jensen, J. B., Birkbak, N. J. & Dyrskjøt, L. (2025). Low T cell diversity associates with poor outcome in bladder cancer: A comprehensive longitudinal analysis of the T cell receptor repertoire. Cell Reports Medicine, 6(5), Article 102101. https://doi.org/10.1016/j.xcrm.2025.102101

Nielsen, T. T., Bali, P., Grove, J., Mohr-Jensen, C., Werge, T., Dalsgaard, S., Børglum, A. D., Sonuga-Barke, E., Minnis, H., Corfield, E. C., Tbartz van Elst, L., Mattheisen, M., de Wit, M. M., Uddin, M. J., Anney, R. J. L., Scherer, S. W., Bourgeron, T., Polderman, T. J. C., Autism Spectrum Working Group of the Psychiatric Genomics Consortium & Demontis, D. (2025). Genetic Architecture and Risk of Childhood Maltreatment Across 5 Psychiatric Diagnoses. JAMA Psychiatry, Article e0243639. Advance online publication. https://doi.org/10.1001/jamapsychiatry.2025.0828

Kofod Petersen, A., Forgie, A., Villesen, P. & Staun Larsen, L. (2025). 3D dental similarity quantification in forensic odontology identification. Forensic Science International, 370, Article 112462. https://doi.org/10.1016/j.forsciint.2025.112462

Gadeberg, T. A. F., Jørgensen, M. H., Olesen, H. G., Lorentzen, J., Harwood, S. L., Almeida, A. V., Fruergaard, M. U., Jensen, R. K., Kanis, P., Pedersen, H., Tranchant, E., Petersen, S. V., Thøgersen, I. B., Kragelund, B. B., Lyons, J. A., Enghild, J. J. & Andersen, G. R. (2025). Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring. Nature Structural and Molecular Biology, 32(5), 884-895. Article 872536. https://doi.org/10.1038/s41594-024-01467-4

Bruhn, D., Griffin, K. L. & Møller, I. M. (2025). Importance of Timing of Dark Acclimation for Estimating Light Inhibition of Leaf Respiratory CO₂ Efflux. Plant, Cell & Environment, 48(5), 3151-3158. https://doi.org/10.1111/pce.15335

Midtgaard, S. R., Hansen, M. S., Drachmann, N., Geng, X., Blans, K. I. M., Møbjerg, M. M. F., Frølund, A. F., Rasmussen, J. T. & Ostenfeld, M. S. (2025). Industrial Scale Production and Characterization of a Whey Fraction Enriched in Extracellular Vesicle Material. Journal of Extracellular Biology, 4(5), Article e70044. https://doi.org/10.1002/jex2.70044

Nowak, J. S., Kruuse, N., Rasmussen, H. Ø., Tian, P., Astono, J., Schultz-Nielsen, S., Thøgersen, M. S., Stougaard, P., Pedersen, J. S. & Otzen, D. E. (2025). Quaternary stabilization of a GH2 β-galactosidase from the psychrophile A. ikkensis, a flexible and unstable dimeric enzyme. Protein Science, 34(5), Article e70141. https://doi.org/10.1002/pro.70141

Simonsen, B., Rübsam, H., Kolte, M. V., Larsen, M. M., Krönauer, C., Gysel, K., Laursen, M., Feng, F., Sezer, G., Oldroyd, G. E. D., Stougaard, J., Fort, S., Radutoiu, S. & Andersen, K. R. (2025). The Medicago truncatula LYR4 intracellular domain serves as a scaffold in immunity signaling independent of its phosphorylation activity. New Phytologist, 246(4), 1423-1431. https://doi.org/10.1111/nph.70067

Christiansen, G. B., Petersen, L. V., Chatwin, H., Yilmaz, Z., Schendel, D., Bulik, C. M., Grove, J., Brikell, I., Semark, B. D., Holde, K., Abdulkadir, M., Hübel, C., Albiñana, C., Vilhjálmsson, B. J., Børglum, A. D., Demontis, D., Mortensen, P. B. & Larsen, J. T. (2025). The role of co-occurring conditions and genetics in the associations of eating disorders with attention-deficit/hyperactivity disorder and autism spectrum disorder. Molecular Psychiatry, 30(5), 2127-2136. Article 132. https://doi.org/10.1038/s41380-024-02825-w

André, A. A. M., Rehnberg, N., Garg, A. & Kjærgaard, M. (2025). Toward Design Principles for Biomolecular Condensates for Metabolic Pathways. Advanced Biology, 9(5), Article 2400672. https://doi.org/10.1002/adbi.202400672

Schulz, L., Ung, K. L., Zuzic, L., Koutnik-Abele, S., Schiøtt, B., Stokes, D. L., Pedersen, B. P. & Hammes, U. Z. (2025). Transport of phenoxyacetic acid herbicides by PIN-FORMED auxin transporters. Nature Plants, 11(5), 1049-1059. https://doi.org/10.1038/s41477-025-01984-0

Andersen, C. G., Bavnhøj, L., Brag, S., Bohush, A., Chrenková, A., Driller, J. H. & Pedersen, B. P. (2025). Comparative analysis of STP6 and STP10 unravels molecular selectivity in sugar transport proteins. Proceedings of the National Academy of Sciences of the United States of America, 122(17), Article e2417370122. https://doi.org/10.1073/pnas.2417370122

Riedelbauch, S., Masser, S., Fasching, S., Lin, S. Y., Salgania, H. K., Aarup, M., Ebert, A., Jeske, M., Levine, M. T., Stelzl, U. & Andersen, P. (2025). Recurrent innovation of protein-protein interactions in the Drosophila piRNA pathway. EMBO Journal, Article 98. Advance online publication. https://doi.org/10.1038/s44318-025-00439-8

Auxillos, J., Stigliani, A., Vaagensø, C. S., Garland, W., Niazi, A. M., Valen, E., Jensen, T. H. & Sandelin, A. (2025). True length of diverse capped RNA sequencing (TLDR-seq): 5'-3'-end sequencing of capped RNAs regardless of 3'-end status. Nucleic Acids Research, 53(6), Article gkaf240. https://doi.org/10.1093/nar/gkaf240

Digel, L., Justesen, M. L., Madsen, N. S., Fransaert, N., Wouters, K., Bonné, R., Plum-Jensen, L. E., Marshall, I. P. G., Jensen, P. B., Nicolas-Asselineau, L., Drace, T., Bøggild, A., Hansen, J. L., Schramm, A., Bøjesen, E. D., Nielsen, L. P., Manca, J. V. & Boesen, T. (2025). Comparison of cable bacteria genera reveals details of their conduction machinery. EMBO Reports, 26(7), 1749-1767. Article 13699. https://doi.org/10.1038/s44319-025-00387-8

Basse Hansen, S., Flygaard, R. K., Kjaergaard, M. & Nissen, P. (2025). Structure of the [Ca]E2P intermediate of Ca²⁺-ATPase 1 from Listeria monocytogenes. EMBO Reports, 26(7), 1709-1723. Article eadd9742. https://doi.org/10.1038/s44319-025-00392-x

PGC TS Working Group & 23andMe Research Team (2025). Genome-Wide Association Study Meta-Analysis of 9619 Cases With Tic Disorders. Biological Psychiatry, 97(7), 743-752. https://doi.org/10.1016/j.biopsych.2024.07.025

Hong, Z., Tesic, N. & Bofill-De Ros, X. (2025). Analysis of Processing, Post-Maturation, and By-Products of shRNA in Gene and Cell Therapy Applications. Methods and Protocols, 8(2), Article 38. https://doi.org/10.3390/mps8020038

Mundy, J., Hall, A. S. M., Agerbo, E., Albiñana, C., Steinbach, J., Vilhjálmsson, B. J., Østergaard, S. D. & Musliner, K. L. (2025). Genetic Confounding of the Association Between Age at First Hormonal Contraception and Depression. Acta Psychiatrica Scandinavica, 151(4), 529-536. https://doi.org/10.1111/acps.13774

Li, Z., Xue, Y., Duan, Y., Yuan, W., Chen, C., Shi, S., Su, X. C., Kisiswa, L., Fan, J. S. & Lin, Z. (2025). Heterotypic interactions among members of the death domain superfamily with implications for p75^NTR-mediated co-signaling. International Journal of Biological Macromolecules, 304(Part 1), Article 140791. https://doi.org/10.1016/j.ijbiomac.2025.140791

Dardani, C., Robinson, J. W., Jones, H. J., Rai, D., Stergiakouli, E., Grove, J., Gardner, R., McIntosh, A. M., Havdahl, A., Hemani, G., Davey Smith, G., Richardson, T. G., Gaunt, T. R. & Khandaker, G. M. (2025). Immunological drivers and potential novel drug targets for major psychiatric, neurodevelopmental, and neurodegenerative conditions. Molecular Psychiatry, Article e1004092. Advance online publication. https://doi.org/10.1038/s41380-025-03032-x

Bruhn, D., Fan, Y., Griffin, K. L., Cowan-Turner, D., Scafaro, A. P., Møller, I. M. & Atkin, O. K. (2025). Importance of the leaf respiratory quotient. Physiologia Plantarum, 177(2), Article e70235. https://doi.org/10.1111/ppl.70235

van den Berg, J. & Zeller, P. (2025). Shining a light on cell biology of the nucleus with single-cell sequencing. Current Opinion in Cell Biology, 93, Article 102468. https://doi.org/10.1016/j.ceb.2025.102468

Fraifeld, V. & Rattan, S. (2025). Stem cells in ageing and longevity: a new section in Biogerontology. Biogerontology, 26, Article 69. https://doi.org/10.1007/s10522-025-10217-y

Conover, C. A. & Oxvig, C. (2025). The IGF System and Aging. Endocrine Reviews, 46(2), 214-223. https://doi.org/10.1210/endrev/bnae029

Marzookian, K., Aliakbari, F., Hourfar, H., Sabouni, F., Otzen, D. E. & Morshedi, D. (2025). The neuroprotective effect of human umbilical cord MSCs-derived secretome against α-synuclein aggregates on the blood-brain barrier. International Journal of Biological Macromolecules, 304(Part 1), Article 140387. https://doi.org/10.1016/j.ijbiomac.2025.140387

Shah, A., Zhang, X., Snee, M., Lockhart-Cairns, M. P., Levy, C. W., Jowitt, T. A., Birchenough, H. L., Dean, L., Collins, R., Dodd, R. J., Roberts, A. R. E., Enghild, J. J., Mantovani, A., Fontana, J., Baldock, C., Inforzato, A., Richter, R. P. & Day, A. J. (2025). The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix. Matrix biology : journal of the International Society for Matrix Biology, 136, 52-68. https://doi.org/10.1016/j.matbio.2025.01.002

O’Leary, E., Jiang, Y., Kristensen, L. S., Hansen, T. B. & Kjems, J. (2025). The therapeutic potential of circular RNAs. Nature Reviews Genetics, 26(4), 230-244. Article 2629. https://doi.org/10.1038/s41576-024-00806-x

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