Department of Molecular Biology and Genetics

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Latest peer-reviewed publications at MBG

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Demirovic, D., de Toda, I. M., Nizard, C. & Rattan, S. (2014). Differential translocation of heat shock factor-1 after mild and severe stress to human skin fibroblasts undergoing aging in vitro. Journal of Cell Communication and Signaling, 8(4), 333-339. https://doi.org/10.1007/s12079-014-0244-8
Cheema, M. U., Damkier, H. H., Nielsen, J., Poulsen, E. T., Enghild, J. J., Fenton, R. A. & Praetorius, J. (2014). Distal Renal Tubules Are Deficient in Aggresome Formation and Autophagy upon Aldosterone Administration. PLoS One, 9(7), e101258. https://doi.org/10.1371/journal.pone.0101258
Lopes, P., Dyrnesli, H., Lorenzen, N., Otzen, D. & Ferapontova, E. (2014). Electrochemical Analysis of the Fibrillation of Parkinson's Disease α-synuclein. Analyst, 139(4), 749-756. https://doi.org/10.1039/C3AN01616A
Eickhardt, E. A., Als, T. D., Mattheisen, M., Nyegaard, M., Demontis, D., Grove, J., Andorsdottir, G., Biskopstø, M., Wang, A., Mors, O., Bolund, L., Wang, J., Børglum, A. & Lescai, F. (2014). Enrichment Analysis of Genomic features to Identify Genome-Wide Patterns of Insertions/Deletions in Cases of Psychiatric Disorders from the Faroe Islands. Poster session presented at XXII World Congress of Psychiatric Genetics, København, Danmark, Denmark.
Jørgensen, P. & Rattan, S. (2014). Extracellular Matrix Modulates Morphology, Growth, Oxidative Stress Response and Functionality of Human Skin Fibroblasts during Aging In Vitro. Journal of Aging Science, 2(2). https://doi.org/10.4172/2329-8847.1000122
Ottaviani, A., Tesauro, C., Fjelstrup, S., Hougaard, R. F., Fiorani, P., Desideri, A. & Knudsen, B. R. (2014). Extraction of active enzymes from “hard-to-break-cells”: Evaluation by a RCA-based assay. https://doi.org/10.1109/ICSENS.2014.6985363
Okholm, A., Kjems, J. & Astakhova, K. (2014). Fluorescence detection of natural RNA using rationally designed "clickable" oligonucleotide probes. RSC Advances, 4(86), 45653-45656. https://doi.org/10.1039/c4ra07165d
Tomasiak, T. M., Pedersen, B. P., Chaudhary, S., Rodriguez, A., Colmanares, Y. R., Roe-Zurz, Z., Thamminana, S., Tessema, M. & Stroud, R. M. (2014). General qPCR and Plate Reader Methods for Rapid Optimization of Membrane Protein Purification and Crystallization Using Thermostability Assays. Current Protocols in Protein Science, 77, 29.11.1-29.11.14. https://doi.org/10.1002/0471140864.ps2911s77
Islam, M. S., Studer, B., Møller, I. M. & Asp, T. (2014). Genetics and biology of cytoplasmic male sterility and its applications for forage and turf grass breeding. Plant Breeding, 133(3), 299-312. https://doi.org/10.1111/pbr.12155
Do, D. N., Strathe, A. B., Ostersen, T., Pant, S. D. & Kadarmideen, H. N. (2014). Genome-wide association and pathway analysis of feed efficiency in pigs reveal candidate genes and pathways for residual feed intake. Frontiers in Genetics, 5(AUG), Article Article 307. https://doi.org/10.3389/fgene.2014.00307
Ngoc Do, D., Ostersen, T., Strathe, A. B., Mark, T., Jensen, J. & Kadarmideen, H. N. (2014). Genome-wide association and systems genetic analyses of residual feed intake, daily feed consumption, backfat and weight gain in pigs. BMC Genetics, 15, Article 27. https://doi.org/10.1186/1471-2156-15-27
Pedersen, J. S., Valen, E., Velazquez, A. M. V., Parker, B. J., Rasmussen, M., Lindgreen, S., Lilje, B., Tobin, D. J., Kelly, T. K., Vang, S., Andersson, R., Jones, P. A., Hoover, C. A., Tikhonov, A., Prokhortchouk, E., Rubin, E. M., Sandelin, A. G., Gilbert, M. T. P., Krogh, A. ... Orlando, L. A. A. (2014). Genome-wide nucleosome map and cytosine methylation levels of an ancient human genome. Genome Research, 24, 454-466. https://doi.org/10.1101/gr.163592.113
Pujolar, J. M., Jacobsen, L. M. W., Als, T. D., Frydenberg, J., Munch, K., Jonsson, B., Jian, J. B., Cheng, L., Maes, G. E., Bernatchez, L. & Hansen, M. M. (2014). Genome-wide single generation signatures of local selection in the panmictic European eel. Molecular Ecology, 23, 2514-2528. https://doi.org/10.1111/mec.12753
Børglum, A. D., Demontis, D., Grove, J., Pallesen, J., Hollegaard, M. V., Pedersen, C. B., Hedemand, A., Mattheisen, M., Uitterlinden, A., Nyegaard, M., Orntoft, T., Wiuf, C., Didriksen, M., Nordentoft, M., Nöthen, M. M., Rietschel, M., Ophoff, R. A., Cichon, S., Yolken, R. H. ... GROUP Investigators (2014). Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci. Molecular Psychiatry, Mar;19(3), 325-33. https://doi.org/10.1038/mp.2013.2
Tessarz, P., Santos-Rosa, H., Robson, S. C., Sylvestersen, K. B., Nelson, C. J., Nielsen, M. L. & Kouzarides, T. (2014). Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification. Nature, 505(7484), 564-568. https://doi.org/10.1038/nature12819
Rattan, S. (2014). Guest Editorial. Prime, 4. http://content.yudu.com/A2zatm/PrimeJul2014/resources/1.htm
Le Bourg, E. & Rattan, S. (2014). Hormesis and trade-offs: A comment. Dose-Response, 12(4), 522-524. https://doi.org/10.2203/dose-response.14-054.Le_Bourg, https://doi.org/10.2203/dose-response.14-054.LeBourg
Iversen, O. S., Thomsen, B. S. & Elbæk, L. (2014). IDC 2014 chairs' welcome. -, iii.
Yusoff, M. F. B. M., Guo, Z. & Fedosov, S. (2014). Kinetic analysis of esterification using liquid lipase. In 105th AOCS Annual Meeting and Expo, Abstracts AOCS Press. http://www.aocs.org/Meetings/content.cfm?ItemNumber=40455
Li, W., Fedosov, S., Tan, T., Xu, X. & Guo, Z. (2014). Kinetic Insights of DNA/RNA Segment Salts Catalyzed Knoevenagel Condensation Reaction. A C S Catalysis, 4(9), 3294–3300. https://doi.org/10.1021/cs500882r
Yusoff, M. F. B. M., Fedosov, S. & Guo, Z. (2014). Kinetic Model of Biodiesel Production using Liquid Lipase Callera Trans L. (TLL). In 12th Euro Fed Lipid Congress Book of Abstracts: Oils, Fats and Lipids: From Lipidomics to Industrial Innovation https://gdch.enterprise-ems.de/tms/frontend/index.cfm?l=4569&id=0&dat_h=&sp_id=2&modus=
Liu, W., Kavaliauskas, D., Schrader, J., Poruri, K., Birkedal, V., Goldman, E., Jakubowski, H., Mandecki, W., Uhlenbeck, O., Knudsen, C. R., Goldman, Y. & Cooperman, B. (2014). Labeled EF-Tus for rapid kinetic studies of pretranslocation complex formation. A C S Chemical Biology, 9(10), 2421-2431.
Jørgensen, P., Milkovic, L., Zarkovic, N., Waeg, G. & Rattan, S. I. S. (2014). Lipid peroxidation-derived 4-hydroxynonenal-modified proteins accumulate in human facial skin fibroblasts during ageing in vitro. Biogerontology, 15(1), 105-110. https://doi.org/10.1007/s10522-013-9482-z
Gao, S., Hein, S., Dagnæs-Hansen, F., Weyer, K., Yang, C., Nielsen, R., Christensen, E. I., Fenton, R. A. & Kjems, J. (2014). Megalin-Mediated Specific Uptake of Chitosan/siRNA Nanoparticles in Mouse Kidney Proximal Tubule Epithelial Cells Enables AQP1 Gene Silencing. Theranostics, 4(10), 1039-51. https://doi.org/10.7150/thno.7866
Pham, L. D., Do, D. N., Nam, L. Q., van Ba, N., Minh, L. T. A., Hoan, T. X., Cuong, V. C. & Kadarmideen, H. N. (2014). Molecular genetic diversity and genetic structure of Vietnamese indigenous pig populations. Journal of Animal Breeding and Genetics, 131(5), 379-386. https://doi.org/10.1111/jbg.12068
Rattan, S. (2014). Molecular gerontology: from homeodynamics to hormesis. Current Pharmaceutical Design, 20(18), 3036-3039. https://doi.org/10.2174/13816128113196660708
Buttenschøn, H. N., Foldager, L., Elfving, B., Poulsen, P. H. P., Uher, R. & Mors, O. (2014). Neurotrophic factors in depression in response to treatment.
Andersson, R., Andersen, P. R., Valen, E., Core, L. J., Bornholdt, J., Boyd, M., Heick Jensen, T. & Sandelin, A. (2014). Nuclear stability and transcriptional directionality separate functionally distinct RNA species. Nature Communications, 5, 1-10. Article 5336. https://doi.org/10.1038/ncomms6336
Kjems, J., Ferapontova, E. & Gothelf, K. V. (Eds.) (2014). Nucleic Acid Nanotechnology. Springer. Nucleic Acids and Molecular Biology Vol. 29 https://doi.org/10.1007/978-3-642-38815-6
Gusev, A., Lee, S. H., Trynka, G., Finucane, H., Vilhjálmsson, B. J., Xu, H., Zang, C., Ripke, S., Bulik-Sullivan, B., Stahl, E., Kähler, A. K., Hultman, C. M., Purcell, S. M., McCarroll, S. A., Daly, M., Pasaniuc, B., Sullivan, P. F., Neale, B. M., Wray, N. R. ... Schizophrenia Working Group of the Psychiatric Genomics Consortium (Manuel Mattheisen and Jakob Grove, members) (2014). Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases. American Journal of Human Genetics, 95(5), 535-52. https://doi.org/10.1016/j.ajhg.2014.10.004
Ghodke, S. D., Jensen, G. V., Svane, A. S. P., Weise, K., Søndergaard, A., Behrens, M. A., Pedersen, J. S., Nielsen, N. C., Pedersen, J. S., Winter, R. & Otzen, D. (2014). Polymorphism, metastable species and interconversion: the many states of glucagon fibrils. In V. Uversky & Y. Lyubchenko (Eds.), Bio-nanoimaging: Protein misfolding and aggregation (pp. 373-386). Elsevier. https://doi.org/10.1016/B978-0-12-394431-3.00034-1
Als, T. D., Lescai, F., Dahl, H. A., Grove, J., Demontis, D., Wang, A. G., Andorsdottir, G., Biskopstø, M., Johansen, O., Nyegaard, M., Bolund, L., Mors, O., Wang, J. & Børglum, A. (2014). Population Structure & Cryptic Relatedness of the isolated Population of the Faroe Islands. Poster session presented at XXII World Congress of Psychiatric Genetics, København, Denmark.
Kjems, J., Ferapontova, E. & Gothelf, K. V. (2014). Preface. In J. Kjems, E. Ferapontova & K. V. Gothelf (Eds.), Nucleic Acid Nanotechnology (pp. ix-x). Springer.
Bek-Thomsen, M., Lomholt, H. B., Scavenius, C., Enghild, J. J. & Brüggemann, H. (2014). Proteome Analysis of Human Sebaceous Follicle Infundibula Extracted from Healthy and Acne-Affected Skin. PLoS One, 9(9), e107908. https://doi.org/10.1371/journal.pone.0107908
Wang, W.-Q., Ye, J.-Q., Rogowska-Wrzesinska, A., Wojdyla, K. I., Jensen, O. N., Møller, I. M. & Song, S.-Q. (2014). Proteomic Comparison between Maturation Drying and Prematurely Imposed Drying of Zea mays Seeds Reveals a Potential Role of Maturation Drying in Preparing Proteins for Seed Germination, Seedling Vigor, and Pathogen Resistance. Journal of Proteome Research, 13(2), 606-626. https://doi.org/10.1021/pr4007574
Sottrup-Jensen, L. & Andersen, G. R. (2014). Purification of human complement protein c5. In The Complete System: Mehods and Protocols (Vol. 1100, pp. 93-102). Springer. https://doi.org/10.1007/978-1-62703-724-2_7
Terczynska-Dyla, E., Bibert, S., Duong, F. H. T., Krol, I., Jørgensen, S., Collinet, E., Kutalik, Z., Aubert, V., Cerny, A., Kaiser, L., Malinverni, R., Mangia, A., Moradpour, D., Müllhaupt, B., Negro, F., Santoro, R., Semela, D., Semmo, N., Swiss Hepatitis C Cohort Study Group ... Hartmann, R. (2014). Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes. Nature Communications, 5, Article 5699. https://doi.org/10.1038/ncomms6699
Sükösd, Z., Andersen, E. S. & Lyngsø, R. (2014). SCFGs in RNA secondary structure prediction: a hands-on approach. Methods in Molecular Biology, 1097, 143-62. https://doi.org/10.1007/978-1-62703-709-9__8, https://doi.org/10.1007/978-1-62703-709-9_8
Sanggaard, K. W., Bechsgaard, J. S., Fang, X., Duan, J., Dyrlund, T. F., Gupta, V., Jiang, X., Cheng, L., Fan, D., Feng, Y., Han, L., Huang, Z., Wu, Z., Liao, L., Settepani, V., Thøgersen, I. B., Vanthournout, B., Wang, T., Zhu, Y. ... Wang, J. (2014). Spider genomes provide insight into composition and evolution of venom and silk. Nature Communications, 5, Article 3765. https://doi.org/10.1038/ncomms4765
Bretes, H., Rouviere, J. O. E. M., Leger, T., Oeffinger, M., Devaux, F., Doye, V. & Palancade, B. (2014). Sumoylation of the THO complex regulates the biogenesis of a subset of mRNPs. Nucleic Acids Research. https://doi.org/10.1093/nar/gku124
Sun, M., Wang, M., Chen, M., Dagnæs-Hansen, F., Le, D. Q. S., Baatrup, A., Horsman, M. R., Kjems, J. & Bünger, C. (2014). Sustained Drug Delivery Device for Treatment of Breast Cancer and Bone Metastases. #1167. Poster session presented at Orthopedic Research Society annual meeting 2014, New Orleans, United States.
Kogelman, L. J. A., Pant, S. D., Fredholm, M. & Kadarmideen, H. N. (2014). Systems genetics of obesity in an F2 pig model by genome-wide association, genetic network, and pathway analyses. Frontiers in Genetics, 5(JUL), Article Article 214. https://doi.org/10.3389/fgene.2014.00214
Salvato, F., Havelund, J. F., Chen, M., Rao, R. S. P., Rogowska-Wrzesinska, A., Jensen, O. N., Gang, D. R., Thelen, J. J. & Møller, I. M. (2014). The Potato Tuber Mitochondrial Proteome. Plant Physiology, 164(2), 637-653 . https://doi.org/10.1104/pp.113.229054
Okholm, A. H., Schaffert, D. H. & Kjems, J. (2014). Towards Defined DNA and RNA Delivery Vehicles Using Nucleic Acid Nanotechnology. In Chemical Biology of Nucleic Acids (pp. 325-345). Springer. https://doi.org/10.1007/978-3-642-54452-1_18
Bay-Richter, C., Buttenschøn, H. N., Foldager, L., Kolstad, H. A., Kaerlev, L., Mors, O. & Wegener, G. (2014). Toxoplasma gondii seropositivity is positively associated with anxiety and burnout-syndrome. Abstract from CINP World Congress, Vancouver, Canada. https://doi.org/10.1017/S1461145714000741
Sand, A., Holt, M. K., Johansen, J., Brodal, G. S., Mailund, T. & Pedersen, C. N. S. (2014). tqDist: A Library for Computing the Quartet and Triplet Distances Between Binary and General Trees. Bioinformatics, 30(4), 2079-2080. https://doi.org/10.1093/bioinformatics/btu157
Aagaard, J., Nissen, F., Wernlund, A., Foldager, L. & Merinder, L. (2014). Valuable intervention against the excess mortality of psychiatric patients. Poster session presented at Annual Conference of the International Society for Bipolar Disorder, Seoul, Korea, Republic of. https://doi.org/10.1111/bdi.12189
Kogelman, L. J. A. & Kadarmideen, H. N. (2014). Weighted Interaction SNP Hub (WISH) network method for building genetic networks for complex diseases and traits using whole genome genotype data. BMC Systems Biology, 8, S5. https://doi.org/10.1186/1752-0509-8-S2-S5
Kjaer, T. R., Thiel, S. & Andersen, G. R. (2013). Toward a structure-based comprehension of the lectin pathway of complement. Molecular Immunology, 56(4), 413-422. https://doi.org/10.1016/j.molimm.2013.05.007
Favaro, F. P., Alvizi, L., Zechi-Ceide, R. M., Bertola, D., Felix, T. M., de Souza, J., Raskin, S., Twigg, S. R. F., Weiner, A. M. J., Armas, P., Margarit, E., Calcaterra, N. B., Andersen, G. R., McGowan, S. J., Wilkie, A. O. M., Richieri-Costa, A., de Almeida, M. L. G. & Passos-Bueno, M. R. (2013). A Noncoding Expansion in EIF4A3 Causes Richieri-Costa-Pereira Syndrome, a Craniofacial Disorder Associated with Limb Defects. American Journal of Human Genetics, 94(1), 120-128. https://doi.org/10.1016/j.ajhg.2013.11.020

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Lisbeth Heilesen