Department of Molecular Biology and Genetics

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 Department of Molecular Biology and Genetics Research Peer-reviewed articles

Peer-reviewed articles

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Latest peer-reviewed publications at MBG

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Parker, B. J., Moltke, I., Roth, A. A. E., Washietl, S., Wen, J., Kellis, M., Breaker, R. & Pedersen, J. S. (2011). New families of human regulatory RNA structures identified by comparative analysis of vertebrate genomes. Genome Research, 21(11), 1929-43. https://doi.org/10.1101/gr.112516.110
Vestergaard, A. L., Thorup, K., Knudsen, U. B., Munk, T., Rosbach, H., Poulsen, J. B., Guldberg, P. & Martensen, P. M. (2011). Oncogenic events associated with endometrial and ovarian cancers are rare in endometriosis. Molecular Human Reproduction, 17(4), 243-254. https://doi.org/10.1093/molehr/gar049
Roy, A., D'Annessa, I., Nielsen, C. J. F., Tordrup, D. P., Laursen, R. R., Andersen, F. F., Desideri, A. & Knudsen, B. R. (2011). Peptide Inhibition of Topoisomerase IB from Plasmodium falciparum. Molecular Biology International, 854626. https://doi.org/10.4061/2011/854626
Brinkmann, C. R., Thiel, S., Larsen, M. K., Petersen, T. E., Jensenius, J. C. & Heegaard, C. W. (2011). Preparation and comparison of cytotoxic complexes formed between oleic acid and either bovine or human (alpha)-lactalbumin. Journal of Dairy Science, 94(5), 2159-2170.
Brinkmann, C. R., Thiel, S., Larsen, M. K., Petersen, T. E., Jensenius, J. C. & Heegaard, C. W. (2011). Preparation and comparison of cytotoxic complexes formed between oleic acid and either bovine or human α-lactalbumin. Indian Journal of Dairy Science, 94(5), 2159-2170. https://doi.org/10.3168/jds.2010-3622
Otzen, D. (2011). Protein-surfactant interactions a tale of many states. BBA General Subjects, 1814(5), 562-91. https://doi.org/10.1016/j.bbapap.2011.03.003
Simonsen, M. & Pedersen, C. N. S. (2011). Rapid Computation of Distance Estimators from Nucleotide and Amino Acid Alignments. In Proceedings of the 26th Annual ACM Symposium on Applied Computing Association for Computing Machinery.
Dupont, D. M., Madsen, J. B., Bøtkjær, K. A., Tavitian, B., Duconge, F., Kjems, J. & Andreasen, P. (2011). RNA aptamers to the cancer-associated proteins UPA and PAI-1 with therapeutic potential. Nucleic Acid Therapeutics, 21(5).
Desbrosses, G. J. & Stougaard, J. (2011). Root nodulation: a paradigm for how plant-microbe symbiosis influences host developmental pathways. Cell Host & Microbe, 10(4), 348-58. https://doi.org/10.1016/j.chom.2011.09.005
Basaiawmoit, R. V., Oliveira, C. L. P., Runager, K., Sørensen, C. S., Behrens, M. A., Jonsson, B.-H., Kristensen, T., Klintworth, G. K., Enghild, J. J., Pedersen, J. S. & Otzen, D. E. (2011). SAXS models of TGFBIp reveal a trimeric structure and show that the overall shape is not affected by the Arg124His mutation. Journal of Molecular Biology, 408(3), 503-513. https://doi.org/10.1016/j.jmb.2011.02.052
Weber, M., Schneider, D., Prodöhl, A., Dreher, C., Becker, C., Underhaug, J., Svane, A. S. P., Malmendal, A., Nielsen, N. C. & Otzen, D. (2011). SDS-facilitated in vitro formation of a transmembrane B-type cytochrome is mediated by changes in local pH. Journal of Molecular Biology, 407(4), 594-606. https://doi.org/10.1016/j.jmb.2011.02.005
Østergaard, S. D., Dinesen, P. T. & Foldager, L. (2011). Sensitivity x PPV is a recognized test called the clinical utility index (CUI+). The Authors Reply. European Journal of Epidemiology, 26, 252-252. https://doi.org/10.1007/s10654-011-9561-x
Wang, J., Jensen, U. B., Jensen, G. V., Shipovskov, S., Balakrishnan, V. S., Otzen, D., Pedersen, J. S., Besenbacher, F. & Sutherland, D. S. (2011). Soft Interactions at Nanoparticles Alter Protein Function and Conformation in a Size Dependent Manner. Nano Letters, 11(11), 4985-4991. https://doi.org/10.1021/nl202940k
Lorenzen, E. D., Nogués-Bravo, D., Orlando, L., Weinstock, J., Binladen, J., Marske, K. A., Ugan, A., Borregaard, M. K., Gilbert, M. T. P., Nielsen, R., Ho, S. Y. W., Goebel, T., Graf, K. E., Byers, D., Stenderup, J., Rasmussen, M., Campos, P., Leonard, J. A., Koepfli, K.-P. ... Willerslev, E. (2011). Species-specific responses of Late Quaternary megafauna to climate and humans. Nature, 479(7373), 359-64. https://doi.org/10.1038/nature10574
Nielsen, K. H., Behrens, M. A., He, Y., Oliveira, C. L. P. D., Sottrup-Jensen, L., Hoffmann, S. V., Pedersen, J. S. & Andersen, G. R. (2011). Synergistic activation of eIF4A by eIF4B and eIF4G. Nucleic Acids Research, 39(7), 2678-2689. https://doi.org/10.1093/nar/gkq1206
Malagon, F. & Jensen, T. H. (2011). T-body formation precedes virus-like particle maturation in S. cerevisiae. RNA Biology, 8(2), 184-189. https://doi.org/10.4161/rna.8.2.14822
Jiang, L., Svane, A. S. P., Sørensen, H. P., Jensen, J. K., Hosseini, M., Chen, Z., Weydert, C., Nielsen, J. T., Christensen, A., Yuan, C., Jensen, K. J., Nielsen, N. C., Malmendal, A., Huang, M. & Andreasen, P. (2011). The binding mechanism of a peptidic cyclic serine protease inhibitor. International Journal of Molecular Biology, 412(2), 235-50. https://doi.org/10.1016/j.jmb.2011.07.028
Gislason, T., Pack, A. I., Helgadottir, H. T., Stefansson, K., Besenbacher, S. & Jonsdottir, I. (2011). The CRP and GDNF genes do not contribute to apnea-hypopnea index or risk of obstructive sleep apnea. American Journal of Respiratory and Critical Care Medicine, 184(1), 143-4; author reply 144-5.
Gentry, A. C., Jensen, S. J., Veigaard, C., Knudsen, B. R. & Osheroff, N. (2011). The Geometry of DNA Supercoils Modulates the DNA Cleavage Activity of Human Topoisomerase I. Nucleic Acids Research, 39(3).
Olshansky, S. J., Biggs, S., Achenbaum, W. A., Davison, G., Fried, L., Gutman, G., Kalache, A., Khaw, K.-T., Fernandez, A., Rattan, S., Guimaraes, R. M., Milner, C. & Butler, R. (2011). The global agenda council on the ageing society: policy principles. Global Policy, 2(1), 97-105.
Venø, S. T., Kulikowicz, T., Pestana, C., Stepien, P., Stevnsner, T. V. & Bohr, V. (2011). The Human Suv3 Helicase Interacts with Replication Protein A and Flap Endonuclease 1 in the Nucleus. Biochemical Journal.
Stukenbrock, E. H., Bataillon, T., Dutheil, J. Y., Hansen, T. T., Li, R., Zala, M., McDonald, B. A., Wang, J. & Schierup, M. H. (2011). The making of a new pathogen: Insights from comparative population genomics of the domesticated wheat pathogen Mycosphaerella graminicola and its wild sister species. Genome Research, 21, 2157-2166. https://doi.org/10.1101/gr.118851.110
Gjelstrup, L. C., Andersen, S. H., Petersen, S. V., Enghild, J. J., Blom, A. M., Vorup-Jensen, T. & Thiel, S. (2011). The role of higher-order protein structure in supporting binding by heteroclitic monoclonal antibodies: the monoclonal antibody KIM185 to CD18 also binds C4-binding protein. Molecular Immunology, 49(1-2), 38-47. https://doi.org/10.1016/j.molimm.2011.07.018
Vestergaard, A. L., Knudsen, U. B., Munk, T., Rosbach, H. & Martensen, P. M. (2011). Transcriptional expression of type I interferon response genes and stability of housekeeping genes in the human endometrium and endometriosis. Molecular Human Reproduction, 17(4), 243-254. https://doi.org/10.1093/molehr/gaq100
Frederiksen, P., Hammershøj, M., Bakman, M., Andersen, P. N., Andersen, J. B., Qvist, K. B. & Larsen, L. B. (2011). Variations in Coagulation Properties of Cheese Milk from three Danish Dairy Breeds. Dairy Science & Technology, 91, 309-321. https://doi.org/10.1007/s13594-011-0018-5
Patro, B. S., Hougaard, R. F., Bohr, V. & Stevnsner, T. V. (2011). WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-IDNA covalent complexes. Journal of Cell Science, 124, 3967-3979. https://doi.org/10.1242/jcs.081372
Stukenbrock, E., Jørgensen, F., Zala, M., Hansen, T. T., McDonald, B. A. & Schierup, M. H. (2010). Whole-genome and chromosome evolution associated with host adaptation and speciation of the wheat pathogen Mycosphaerella graminicola. PLoS Genetics, 23(6).
Giehm, L., Lorenzen, N. & Otzen, D. E. (2010). Assays for α-synuclein aggregation. Methods. https://doi.org/10.1016/j.ymeth.2010.12.008
Andersen, C. L., Lamy, P., Thorsen, K., Kjeldsen, E., Wikman, F., Villesen, P., Øster, B., Laurberg, S. & Ørntoft, T. F. (2010). Frequent genomic loss at chr16p13.2 is associated with poor prognosis in colorectal cancer. International Journal of Cancer. https://doi.org/10.1002/ijc.25841
Otzen, D. & Enghild, J. J. (2010). Human phenotypically distinct TGFI corneal dystrophies are linked to the stability of the fourth Fas1 domain of TGFBIp. Journal of Biological Chemistry.
Rahbek, U. L., Nielsen, A. F., Dong, M., You, Y., Chauchereau, A., Oupicky, D., Besenbacher, F., Kjems, J. & Howard, K. A. (2010). Bioresponsive hyperbranched polymers for siRNA and miRNA delivery. Journal of Drug Targeting, 18(10), 812-20. https://doi.org/10.3109/1061186X.2010.527982
Doǧanli, C., Kjærgaard, T., Olsen, A., Oxvig, C., Füchtbauer, E. M. & Lykke-Hartmann, K. (2010). Early developmental expression of mus musculus zinc finger RNA-binding protein compared to orthologs in caenorhabditis elegans and danio rerio and subcellular localization of mus musculus and caenorhabditis elegans zinc finger rna-binding protein in 2-cell mus musculus embryos. DNA and Cell Biology, 29(12), 713-727. https://doi.org/10.1089/dna.2010.1085
Malet, H., Topf, M., Clare, D. K., Ebert, J., Bonneau, F., Basquin, J., Drazkowska, K., Tomecki, R., Dziembowski, A., Conti, E., Saibil, H. R. & Lorentzen, E. (2010). RNA channelling by the eukaryotic exosome. EMBO Reports, 11(12), 936-942.
Dupont, D. M., Madsen, J. B., Hartmann, R. K., Tavitian, B., Ducongé, F., Kjems, J. & Andreasen, P. A. (2010). Serum-stable RNA aptamers to urokinase-type plasminogen activator blocking receptor binding. RNA, 16(12), 2360-9. https://doi.org/10.1261/rna.2338210
Sørensen, M., Dato, S., Christensen, K., McGue, M., Stevnsner, T. V., Bohr, V. & Christiansen, L. (2010). Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data. Aging Cell, 9(6), 1010-1017. https://doi.org/10.1111/j.1474-9726.2010.00627.x.
Doganli, C., Kjærgaard, T., Olsen, A., Oxvig, C., Füchtbauer, E.-M. & Lykke-Hartmann, K. (2010). Early Developmental Expression of Mus musculus ZFR compared to orthologs in Caenorhabditis elegans and Danio rerio and subcellular localization of M. musculus and C. elegans ZFR in 2-cell M. musculus embryos. D N A and Cell Biology, 29(12), 713-27.
Andersen, P. K. & Jensen, T. H. (2010). A pause to splice. Molecular Cell Biology Research Communications, 40(4), 503-5. https://doi.org/10.1016/j.molcel.2010.11.019
Helmig, S. W., Rotaru, A., Arian, D., Kovbasyuk, L., Arnbjerg, J., Ogilby, P. R., Kjems, J., Mokhir, A., Besenbacher, F. & Gothelf, K. V. (2010). Single Molecule Atomic Force Microscopy Studies of Photosensitized Singlet Oxygen Behavior on a DNA Origami Template. A C S Nano, 4(12), 7475-7480. https://doi.org/10.1021/nn102701f
Giehm, L. & Otzen, D. (2010). Strategies to increase the reproducibility of α-synuclein fibrillation in plate reader assays. Analytical Biochemistry, 406(2), 270-281.
Preker, P. & Jensen, T. H. (2010). Translation by remote control. Cell, 143(4), 501-2. https://doi.org/10.1016/j.cell.2010.10.039
Nautrup-Pedersen, G., Dam, S., Laursen, B. S., Siegumfeldt, A. L., Nielsen, K., Goffard, N., Stærfeldt, H. H., Friis, C., Sato, S., Tabata, S., Lorentzen, A., Roepstorff, P. & Stougaard, J. (2010). Proteome analysis of pod and seed development in the model legume Lotus japonicus. Journal of Proteome Research, 9(11), 5715-26. https://doi.org/10.1021/pr100511u
Debnath, D. K. & Otzen, D. E. (2010). Cell-free synthesis and folding of transmembrane OmpA reveals higher order structures and premature truncations. Advances in Biophysical Chemistry, 152(1-3), 80-8. https://doi.org/10.1016/j.bpc.2010.08.003
Giehm, L. & Otzen, D. E. (2010). Erratum to Strategies to increase the reproducibility of protein fibrillization in plate reader assays [Anal. Biochem., 400, (2010), 270-281]. Analytical Biochemistry, 406(2). https://doi.org/10.1016/j.ab.2010.06.047
Kristiansen, H., Scherer, C. A., McVean, M., Iadonato, S. P., Vends, S., Thavachelvam, K., Steffensen, T. B., Horan, K. A., Kuri, T., Weber, F., Paludan, S. R. & Hartmann, R. (2010). Extracellular 2'-5' oligoadenylate synthetase stimulates RNase L-independent antiviral activity: a novel mechanism of virus-induced innate immunity. Journal of Virology, 84(22), 11898-904. https://doi.org/10.1128/JVI.01003-10
Malmström, J., Christensen, B. S., Lovmand, J., Sørensen, E. S., Duch, M. & Sutherland, D. S. (2010). Osteopontin presentation affects cell adhesion-Influence of underlying surface chemistry and nanopatterning of osteopontin. Journal of Biomedical Materials Research. Part A, 95(2), 518-30. https://doi.org/10.1002/jbm.a.32879
Pedersen, J. S., Andersen, C. B. & Otzen, D. (2010). Amyloid structure--one but not the same: the many levels of fibrillar polymorphism. FEBS journal, 277(22), 4591-4601. https://doi.org/10.1111/j.1742-4658.2010.07888.x
Kisiswa, L., Albon, J., Morgan, J. E. & Wride, M. A. (2010). Cellular inhibitor of apoptosis (cIAP1) is down-regulated during Retinal ganglion cell (RGC) maturation. Experimental Eye Research, 91(5), 739-747. https://doi.org/10.1016/j.exer.2010.08.024
Platt, A., Vilhjálmsson, B. J. & Nordborg, M. (2010). Conditions under which genome-wide association studies will be positively misleading. Genetics, 186(3), 1045-52. https://doi.org/10.1534/genetics.110.121665
Asai, R., Kurihara, Y., Fujisawa, K., Sato, T., Kawamura, Y., Kokubo, H., Tonami, K., Nishiyama, K., Uchijima, Y., Miyagawa-Tomita, S. & Kurihara, H. (2010). Endothelin receptor type A expression defines a distinct cardiac subdomain within the heart field and is later implicated in chamber myocardium formation. Development, 137(22), 3823-33. https://doi.org/10.1242/dev.054015
Malmström, J., Christensen, B., Jakobsen, H. P., Lovmand, J., Foldbjerg, R., Kristensen, S., Sorensen, E. S. & Sutherland, D. S. (2010). Large area protein patterning for control of focal adhesion development. European Cells and Materials, 20(SUPPL.3), 169.

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Lisbeth Heilesen