Department of Molecular Biology and Genetics

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 Department of Molecular Biology and Genetics Research Peer-reviewed articles

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Latest peer-reviewed publications at MBG

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Sundekilde, U., Frederiksen, P., Clausen, M. R., Larsen, L. B. & Bertram, H. C. S. (2011). Relationship between the Metabolite Profile and Technological Properties of Bovine Milk from Two Dairy Breeds Elucidated by NMR-based Metabolomics. Journal of Agricultural and Food Chemistry, 59(13), 7360-7367. https://doi.org/10.1021/j202057x
Hollegaard, M. V., Grove, J., Grauholm, J., Kreiner-Moller, E., Bonnelykke, K., Nørgaard, M., Benfield, T. L., Norgaard-Pedersen, B., Mortensen, P. B., Mors, O., Sørensen, H. T., Harboe, Z. B., Børglum, A., Demontis, D., Ørntoft, T. F., Bisgaard, H. & Hougaard, D. M. (2011). Robustness of genome-wide scanning using archived dried blood spot samples as a DNA source. BMC Genetics, 12(1), 58. https://doi.org/10.1186/1471-2156-12-58
Taschner, M., Bhogaraju, S., Vetter, M. M., Morawetz, M. & Lorentzen, E. (2011). Biochemical mapping of interactions within the intraflagellar transport (IFT) B core complex: IFT52 binds directly to four other IFT-B subunits. J. Biol. Chem., 286(30), 26344-26352.
Østergaard, S. D. & Foldager, L. (2011). Reply. Acta Psychiatrica Scandinavica, 124(1), 75-6. https://doi.org/10.1111/j.1600-0447.2011.01694.x
Birkedal, V., Dong, M., Golas, M. M., Sander, B., Andersen, E. S., Gothelf, K. V., Besenbacher, F. & Kjems, J. (2011). Single molecule microscopy methods for the study of DNA origami structures. Microscopy Research and Technique, 74(7), 688-698. https://doi.org/10.1002/jemt.20962
Gourdon, P., Liu, X.-Y., Skjørringe, T., Morth, J. P., Møller, L. B., Pedersen, B. P. & Nissen, P. (2011). Crystal structure of a copper-transporting PIB-type ATPase. Nature, 475(7354), 59-64. https://doi.org/10.1038/nature10191
Vorup-Jensen, T. & Boesen, T. (2011). Protein ultrastructure and the nanoscience of complement activation. Advanced Drug Delivery Reviews. https://doi.org/10.1016/j.addr.2011.05.023
Hamming, O. J., Lutfalla, G., Levraud, J.-P. & Hartmann, R. (2011). Crystal structure of zebrafish Interferons 1 and 2 reveals a conservation of type I Interferon structure in vertebrates. Journal of Virology. https://doi.org/10.1128/JVI.00521-11
Nielsen, J., Kristensen, A. K., Mailund, T. & Pedersen, C. N. S. (2011). A sub-cubic time algorithm for computing the quartet distance between two general trees. Algorithms for Molecular Biology, 6(15). https://doi.org/10.1186/1748-7188-6-15
Brinkmann, C. R., Heegaard, C. W., Petersen, T. E., Jensenius, J. C. & Thiel, S. (2011). The toxicity of bovine α-lactalbumin made lethal to tumor cells is highly dependent on oleic acid and induces killing in cancer cell lines and noncancer-derived primary cells. FEBS journal, 278(11), 1955-67. https://doi.org/10.1111/j.1742-4658.2011.08112.x
Hansen, T. B., Kjems, J. & Bramsen, J. B. (2011). Enhancing miRNA annotation confidence in miRBase by continuous cross dataset analysis. RNA Biology, 8(3), 378-383.
Hvidtjørn, D., Grove, J., Schendel, D., Schieve, L., Sværke, C., Ernst, E. & Thorsen, P. (2011). Risk of Autism Spectrum Disorders in children born after assisted conception. A population based follow-up study. Journal of Epidemiology & Community Health, 65(6), 497-502. https://doi.org/10.1136/jech.2009.093823
Kjærgaard, M. & Poulsen, F. M. (2011). Sequence correction of random coil chemical shifts: correlation between neighbor correction factors and changes in the Ramachandran distribution. Journal of Biomolecular N M R, 50(2), 157-65. https://doi.org/10.1007/s10858-011-9508-2
Ramsgaard, L., Englert, J. M., Manni, M. L., Milutinovic, P. S., Gefter, J., Tobolewski, J., Crum, L., Coudriet, G. M., Piganelli, J., Zamora, R., Vodovotz, Y., Enghild, J. J. & Oury, T. D. (2011). Lack of the receptor for advanced glycation end-products attenuates E. coli pneumonia in mice. PLoS One, 6(5), e20132. https://doi.org/10.1371/journal.pone.0020132
Preker, P., Almvig, K., Christensen, M. S., Valen, E., Mapendano, C. K., Sandelin, A. G. & Jensen, T. H. (2011). PROMoter uPstream Transcripts share characteristics with mRNAs and are produced upstream of all three major types of mammalian promoters. Nucleic Acids Research. https://doi.org/10.1093/nar/gkr370
Bøttger, P. & Pedersen, L. (2011). Mapping of the minimal inorganic phosphate transporting unit of human PiT2 suggests a structure universal to PiT-related proteins from all kingdoms of life. BMC Biochemistry, 12(21). https://doi.org/10.1186/1471-2091-12-21
Nørholm, A.-B., Hendus-Altenburger, R., Bjerre, G. P., Kjærgaard, M., Pedersen, S. F. & Kragelund, B. B. (2011). The intracellular distal tail of the Na+/H+ exchanger NHE1 is intrinsically disordered: implications for NHE1 trafficking. Biochemistry, 50(17), 3469-80. https://doi.org/10.1021/bi1019989
Bhogaraju, S., Taschner, M., Morawetz, M., Basquin, C. & Lorentzen, E. (2011). Crystal structure of the intraflagellar transport complex 25/27. EMBO Journal, 30(10), 1907-1918.
Mlynek, G., Sjöblom, B., Kostan, J., Füreder, S., Maixner, F., Gysel, K., Maixner, F., Obinger, C., Wagner, M., Daims, H. & Djinović-Carugo, K. (2011). Unexpected diversity of chlorite dismutases - a catalytically efficient dimeric enzyme from Nitrobacter winogradskyi. Journal of Bacteriology, 193(10), 2408-2417. https://doi.org/10.1128/JB.01262-10
Scavenius, C., Ghodke, S., Otzen, D. E. & Enghild, J. J. (2011). Hydrogen exchange mass spectrometry as an analytical tool for the analysis of amyloid fibrillogenesis. International Journal of Mass Spectrometry, 302(1-3), 167-173. https://doi.org/10.1016/j.ijms.2010.10.001
Hoffmann, N., Mittnacht, U., Hartmann, H., Baumer, Y., Kjems, J., Oberhoffner, S. & Schlosshauer, B. (2011). Neuronal and glial responses to siRNA-coated nerve guide implants in vitro. Neuroscience Letters, 494(1), 14-8. https://doi.org/10.1016/j.neulet.2011.02.043
Sükösd, Z., Knudsen, B., Værum, M., Kjems, J. & Andersen, E. S. (2011). Multithreaded comparative RNA secondary structure prediction using stochastic context-free grammars. BMC Bioinformatics, 12(103). https://doi.org/10.1186/1471-2105-12-103
Höfer, N., Aragão, D., Lyons, J. A. & Caffrey, M. (2011). Membrane protein crystallization in lipidic mesophases. Hosting lipid effects on the crystallization and structure of a transmembrane peptide. Crystal Growth and Design, 11(4), 1182-1192. https://doi.org/10.1021/cg101384p
Jeppesen, D. K., Bohr, V. & Stevnsner, T. V. (2011). DNA repair deficiency in neurodegeneration. Progress in Neurobiology, 30(94), 166-200.
Lykke-Andersen, S., Mapendano, C. K. & Jensen, T. H. (2011). An ending is a new beginning: Transcription termination supports re-initiation. Cell Cycle, 10(6), 863-865. https://doi.org/10.4161/cc.10.6.14931
Wiklund, E. D., Bramsen, J. B., Hulf, T., Andersen, L. D., Ramanathan, R., Hansen, T. B., Villadsen, S. B., Gao, S., Ostenfeld, M. S., Borre, M., Peter, M. E., Ørntoft, T. F., Kjems, J. & Clark, S. J. (2011). Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer. International Journal of Cancer, 128(6), 1327-1334. https://doi.org/10.1002/ijc.25461
Lin, Z., Jiang, L., Yuan, C., Jensen, J. K., Zhang, X., Luo, Z., Furie, B. C., Furie, B., Andreasen, P. A. & Huang, M. (2011). Structural basis for recognition of urokinase-type plasminogen activator by plasminogen activator inhibitor-1. Journal of Biological Chemistry, 286(9), 7027-32. https://doi.org/10.1074/jbc.M110.204537
Krusell, L., Sato, N., Fukuhara, I., Koch, B. E. V., Grossmann, C., Okamoto, S., Oka-Kira, E., Otsubo, Y., Aubert, G., Nakagawa, T., Sato, S., Tabata, S., Duc, G., Parniske, M., Wang, T. L., Kawaguchi, M. & Stougaard, J. (2011). The Clavata2 genes of pea and Lotus japonicus affect autoregulation of nodulation. Plant Journal, 65(6), 861-871. https://doi.org/10.1111/j.1365-313X.2010.04474.x
Samsel, P. A., Kisiswa, L., Erichsen, J. T., Cross, S. D. & Morgan, J. E. (2011). A novel method for the induction of experimental glaucoma using magnetic microspheres. Investigative Ophthalmology & Visual Science, 52(3), 1671-1675. https://doi.org/10.1167/iovs.09-3921
Giehm, L., Svergun, D. I., Otzen, D. E. & Vestergaard, B. (2011). Low-resolution structure of a vesicle disrupting α-synuclein oligomer that accumulates during fibrillation. Proceedings of the National Academy of Sciences (PNAS), 108(8), 3246-3251. https://doi.org/10.1073/pnas.1013225108
Runager, K., Basaiawmoit, R. V., Deva, T., Andreasen, M., Valnickova, Z., Sørensen, C. S., Karring, H., Thøgersen, I. B., Christiansen, G., Underhaug, J., Kristensen, T., Nielsen, N. C., Klintworth, G. K., Otzen, D. E. & Enghild, J. J. (2011). Human Phenotypically Distinct TGFBI Corneal Dystrophies Are Linked to the Stability of the Fourth FAS1 Domain of TGFBIp. Journal of Biological Chemistry, 286(7), 4951-8. https://doi.org/10.1074/jbc.M110.181099
Kristensen, T. G., Nielsen, J. & Pedersen, C. N. S. (2011). Using Inverted Indices for Accelerating LINGO Calculations. Journal of Chemical Information and Modeling, 51(3), 597-600. https://doi.org/10.1021/ci100437e
Laursen, N. S., Andersen, K. R., Braren, I., Spilllner, E., Sottrup-Jensen, L. & Andersen, G. R. (2011). Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex. EMBO Journal, 30(3), 606-616.
Madsen, E. B., Antolín-Llovera, M., Grossmann, C., Ye, J., Vieweg, S., Broghammer, A., Krusell, L., Radutoiu, S., Jensen, O. N., Stougaard, J. & Parniske, M. (2011). Autophosphorylation is essential for the in vivo function of the Lotus japonicus Nod factor receptor 1 and receptor-mediated signalling in cooperation with Nod factor receptor 5. Plant Journal, 65(3), 404-17. https://doi.org/10.1111/j.1365-313X.2010.04431.x
Kjærgaard, M., Brander, S. & Poulsen, F. M. (2011). Random coil chemical shift for intrinsically disordered proteins: effects of temperature and pH. Journal of Biomolecular N M R, 49(2), 139-49. https://doi.org/10.1007/s10858-011-9472-x
Cervantes, C. F., Bergqvist, S., Kjærgaard, M., Kroon, G., Sue, S.-C., Dyson, H. J. & Komives, E. A. (2011). The RelA nuclear localization signal folds upon binding to IκBα. Journal of Molecular Biology, 405(3), 754-64. https://doi.org/10.1016/j.jmb.2010.10.055
Jahn, K., Olsen, E. M., Nielsen, M. M., Tørring, T., Mohammadzadegan, R., Andersen, E. S., Gothelf, K. V. & Kjems, J. (2011). Site-Specific Chemical Labeling of Long RNA Molecules. Bioconjugate Chemistry, 22(1), 95-100. https://doi.org/10.1021/bc100422k
Rosenbaum, D. M., Zhang, C., Lyons, J. A., Holl, R., Aragao, D., Arlow, D. H., Rasmussen, S. G. F., Choi, H. J., Devree, B. T., Sunahara, R. K., Chae, P. S., Gellman, S. H., Dror, R. O., Shaw, D. E., Weis, W. I., Caffrey, M., Gmeiner, P. & Kobilka, B. K. (2011). Structure and function of an irreversible agonist-β2 adrenoceptor complex. Nature, 469(7329), 236-242. https://doi.org/10.1038/nature09665
Kristiansen, H., Gad, H. H., Larsen, S. E., Despres, P. & Hartmann, R. (2011). The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities. Journal of Interferon & Cytokine Research, 31(1), 41-47. https://doi.org/10.1089/jir.2010.0107
Østergaard, S. D. & Foldager, L. (2011). The association between physical illness and major depressive episode in general practice. Acta Psychiatrica Scandinavica, 123(4), 290-296. https://doi.org/10.1111/j.1600-0447.2010.01668.x
Martins, H. & Villesen, P. (2011). Improved integration time estimation of endogenous retroviruses with phylogenetic data. PLoS One, 6(3), e14745. https://doi.org/10.1371/journal.pone.0014745
Otzen, D. E. (2011). Mapping the folding pathway of the transmembrane protein DsbB by protein engineering. Protein Engineering Design and Selection (Print), 24(1-2), 139-149. https://doi.org/10.1093/protein/gzq079
De Mita, S., Chantret, N., Loridon, K., Ronfort, J. & Bataillon, T. (2011). Molecular adaptation in flowering and symbiotic recognition pathways: insights from patterns of polymorphism in the legume Medicago truncatula. BMC Evolutionary Biology, 11(1), 229-241. https://doi.org/10.1186/1471-2148-11-229
Grivet, D., Sebastiani, F., Alía, R., Bataillon, T., Torre, S., Zabal-Aguirre, M., Vendramin, G. G. & González-Martínez, S. C. (2011). Molecular footprints of local adaptation in two Mediterranean conifers. Molecular Biology and Evolution, 28(1), 101-16. https://doi.org/10.1093/molbev/msq190
Lützelberger, M. & Kjems, J. (2011). S1 nuclease analysis of alternatively spliced mRNA. Methods in Molecular Biology, 703, 161-71. https://doi.org/10.1007/978-1-59745-248-9_11
Kadarmideen, H. N., Watson-Haigh, N. S. & Andronicos, N. M. (2011). Systems biology of ovine intestinal parasite resistance: Disease gene modules and biomarkers. Molecular BioSystems, 7(1), 235-246. https://doi.org/10.1039/c0mb00190b
Nexø, B. A., Christensen, T., Frederiksen, J., Møller-Larsen, A., Oturai, A. B., Villesen, P., Hansen, B., Nissen, K. K., Laska, M. J., Petersen, T. S., Bonnesen, S., Hedemand, A., Wu, T., Wang, X., Zhang, X., Brudek, T., Maric, R., Søndergaard, H., Sellebjerg, F. T. ... Pedersen, F. S. (2011). The Etiology of Multiple Sclerosis: Genetic Evidence for the Involvement of the Human Endogenous Retrovirus HERV-Fc1. PLoS One, 6(2), e16652. https://doi.org/10.1371/journal.pone.0016652
Lykke-Andersen, S., Tomecki, R., Jensen, T. H. & Dziembowski, A. (2011). The eukaryotic RNA exosome: Same scaffold but variable catalytic subunits. RNA Biology, 8(1).
Debnath, D. K., Basaiawmoit, R. V., Nielsen, K. L. & Otzen, D. E. (2011). The role of membrane properties in Mistic folding and dimerisation. Protein Engineering Design and Selection (Print), 24(1-2), 89-97. https://doi.org/10.1093/protein/gzq095
Hofmeister, M. V., Füchtbauer, E.-M., Fenton, R. A. & Praetorius, J. (2011). The TRPV5 Promoter as a Tool for Generation of Transgenic Mouse Models. Advances in Experimental Medicine and Biology, 704, 277-86. https://doi.org/10.1007/978-94-007-0265-3_15

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Lisbeth Heilesen