We are interested in understanding the molecular mechanisms underlying how plants accommodate symbiotic microorganisms and at the same time defend against pathogens. In legumes, LysM receptor-like kinases perceive carbohydrate-signalling molecules from bacteria (Nod factors and exopolysaccharides) and fungi (Myc factors and chitin) and in this way distinguish symbionts from pathogen. We are investigating how these membrane-bound LysM receptors recognize their different ligands and initiates intracellular signalling using a structural, biochemical and genetic approach. The long-term goal is to uncover the downstream signalling pathways following ligand recognition by identifying the components and sequence of events enabling legume-bacteria symbiosis and defence.

If you are interested in our work and would like to join, please contact Kasper Røjkjær Andersen (kra@mbg.au.dk).