JØRGEN KJEMS: Nanomedicine

There are three main focus areas in the Kjems lab:

a) The understanding of how small non-coding RNA and circular RNA contribute to cell maintenance and disease development with a primary aim of defining new targets for disease intervention.

b) The creation of novel bioimaging and delivery systems for gene medicine including siRNA, miRNA mimics, antimiRs (antisense targeting microRNA) with a specific focus on inflammation, cancer, influenza, and regeneration of damaged tissue (tissue engineering).

c) Design and construction of functionalized self assembled DNA and RNA nanostructures capable of complex biosensing, coupled with controlled action e.g. drug release, enzyme activation, and receptor signaling.

In CellPAT, Jørgen Kjems contributes with key expertises in applied nanotechnology including biomolecular design, bioconjugation, cell delivery and tissue engineering as well as the more basic molecular biology fields of gene expression and cellular growth and development.

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Andersen, M. Ø., Howard, K. A. & Kjems, J. (2009). RNAi using a chitosan/siRNA nanoparticle system: in vitro and in vivo applications. I Methods in Molecular Biology (Bind 555, s. 77-86) https://doi.org/10.1007/978-1-60327-295-7_6

Andersen, E. S., Dong, M., Nielsen, M. M., Jahn, K., Subramani, R., Mamdouh, W., Golas, M. M., Sander, B., Stark, H., Oliveira, C. L. P., Pedersen, J. S., Birkedal, V., Besenbacher, F., Gothelf, K. V. & Kjems, J. (2009). Self-assembly of a nanoscale DNA box with a controllable lid. Nature, 459(7243), 73-6. https://doi.org/10.1038/nature07971

Jahn, K., Nielsen, M. M., Olsen, E. M., Mohammadzadegan, R., Andersen, E. S., Gothelf, K. V. & Kjems, J. (2009). Site-specific labeling of long HIV-1 RNA using DNA templated chemistry. 84-88. Afhandling præsenteret på 6th Annual Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2009, Snowbird, UT, USA.

Larsen, E. K. U., Nielsen, T., Wittenborn, T., Birkedal, H., Vorup-Jensen, T., Jakobsen, M. H., Østergaard, L., Horsman, M. R., Besenbacher, F., Howard, K. A. & Kjems, J. (2009). Size-Dependent Accumulation of PEGylated Silane-Coated Magnetic Iron Oxide Nanoparticles in Murine Tumors. A C S Nano, 3(7), 1947-51. https://doi.org/10.1021/nn900330m

Pallesen, J., Dong, M., Besenbacher, F. & Kjems, J. (2009). Structure of the HIV-1 Rev response element alone and in complex with regulator of virion (Rev) studied by atomic force microscopy. FEBS journal, 276(15), 4223-32. https://doi.org/10.1111/j.1742-4658.2009.07130.x

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Revideret 23.07.2026

Viktor Hauge Ladegaard