During her PhD studies, Anna Dippel Lande investigated the Dynein complex. Dynein is a large protein complex that is found in all cells and i.a. conveys transport of vesicles by walking on the cytoskeleton.

Anna Dippel Lande used the nematode C. elegans as model organism and demonstrated the necessity of the Dynein complex in programmed cell death of germ cells. In worms as well as humans, the vast majority of female germ cells are eliminated by programmed cell death before menopause is reached. The new insights contribute to the understanding of how and which germ cells are selected for elimination by programmed cell death.

Time: Monday 18 August 2014 at 13.00
Place: Building 1531, Room 215, Auditorium D3, Department of Mathematics, Ny Munkegade 116, 8000 Aarhus C
Title of dissertation: Structural Studies of Neuroligand Interaction with the Sorting Receptors Sortilin and SorLA & Novel Role of the Dynein Complex in Germline Apoptosis in C. elegans
Contact information: Anna Dippel Lande, e-mail: adl@mb.au.dk, tel.: +45 40937906
Members of the assessment committee:
Associate Professor Malene Hansen, Sanford-Burnham Medical Research Institute, La Jolla, CA, USA
Professor Jette Sandholm Kastrup, Department of Drug Design and Pharmacology, University of Copenhagen, Denmark
Professor Anni H Andersen (chair), Department of Molecular Biology and Genetics, Aarhus University, Denmark
Main supervisor:
Associate Professor Ernst-Martin Füchtbauer, Department of Molecular Biology and Genetics, Aarhus University, Denmark
Co-supervisor:
Associate Professor Anders Olsen, Department of Molecular Biology and Genetics, Aarhus University, Denmark
Associate Professor Søren S. Thirup, Department of Molecular Biology and Genetics, Aarhus University, Denmark
Language: The PhD dissertation will be defended in English.

The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1521, room 112, 8000 Aarhus C.