The Darwinian purpose of life for a biological system is reproduction and continuation of generations. Once this purpose is fulfilled, the fate of the individual is uncertain and sooner or later every individual faces death. No organism, at an individual level, has ever been shown to live forever, and therefore the consequence of life is given.

During his studies, Dino Demirovic has been doing research in trying to understand how and why human cells lose their youthfulness and become old. One of the main characteristics of the young cells is their ability to tolerate stress, while the old cells cannot do so effectively. To understand these changes, Dino Demirovic has during his studies and research developed a new method to determine seven different cellular stress response pathways simultaneously. This can been used to create stress response profiles of healthy young and old cells, which can be useful to determine the state of health and the biological age of an individual.

PhD degree was completed at the Laboratory of Cellular Ageing, Department of Molecular Biology and Genetics, Faculty of Science and Technology, Aarhus University.

This résumé is prepared by the PhD student.

Time: Wednesday 26 August 2015 at 13.00
Place: Building 1253, room 217, William Sharff, Lakeside Auditorium, Aarhus University, Bartholins Allé 3, 8000 Aarhus C
Title of Dissertation: Establishing stress response profiles in ageing human cells as markers of health
Contact information: Dino Demirovic, e-mail: did@mbg.au.dk
Members of the assessment committee:
Professor Pidder Jansen-Dürr, Forschungsinstitut für Biomedizinische Alternsforschung, University of Innsbruck, Austria
Associate Professor Hanne Cathrine Bisgaard, Department of Cellular and Molecular Medicine, University of Copenhagen
Associate Professor Ernst-Martin Füchtbauer, Department of Molecular Biology and Genetics, Aarhus University (chair)
Main supervisor:
Associate Professor Suresh Rattan, Department of Molecular Biology and Genetics, Aarhus University
Language: The PhD dissertation will be defended in English

The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1521, room 112, 8000 Aarhus C