During her studies, Evdoxia Karadoulama has investigated the roles of the nuclear RNA exosome and its associated proteins in RNA metabolism in human nuclei. The exosome is an essential degradation protein complex which is vital for cell function. It assists in the maturation of RNAs and degrades transcripts, which are unwanted or have completed their function. Evdoxia studied a novel nuclear exosome degradation pathway and delineated its RNA targets. In addition, she studied the regulatory impact of the exosome and its associated proteins in RNA regulation during stem cell differentiation. The new research findings contribute to our understanding of post-transcriptional control of gene expression.

The PhD degree was completed at the Institute of Molecular Biology and Genetics, Faculty of Natural Sciences, Aarhus University.

This résumé was prepared by the PhD student.

Time: Thursday 5 March 2020 at 13.15
Place: Building 1531, room 119, Lecture Theatre D2, Department of Mathematics, Aarhus University, Ny Munkegade 116, 8000 Aarhus C
Title of PhD thesis: Unravelling the pathways and functions of the RNA exosome
Contact information: Evdoxia Karadoulama, e-mail: evka@mbg.au.dk 
Members of the assessment committee:
Associate Professor Eivind Valen, Department of Informatics, University of Bergen, Norway
Senior Winton Group Leader Nicholas Luscombe, Francis Crick Institute, United Kingdom
Professor Finn Skou Pedersen (chair), Department of Molecular Biology and Genetics, Aarhus University, Denmark
Main supervisor:
Professor Torben Heick Jensen, Department of Molecular Biology and Genetics, Aarhus University, Denmark
Co-supervisor:
Professor Albin Sandelin, Department of Biology, Copenhagen University, Denmark
Language: The PhD dissertation will be defended in English

The defense is public.
The PhD thesis is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1521, 8000 Aarhus C.