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Fabien Bonneau: Shape and composition of native mRNA-containing particles isolated from yeast cells

PhD defence, Friday 12 January 2024, Fabien Bonneau

Fabian Bonneau

During his studies, Fabien Bonneau focused on how messenger RNAs (mRNAs) are packaged together with proteins. mRNAs carry the building plans of all proteins across different compartments within our cells. They are fragile molecules, themselves covered with proteins. Using yeast as a model system, Fabien Bonneau established procedures to isolate native mRNAs together with their protein coat. This material allowed him to identify a network of interactions likely responsible for giving these assemblies a compact shape.
The new research findings contribute to the understanding of how mRNAs are packaged into compact particles before travelling within our cells.
The PhD degree was obtained at the Department of Molecular Biology and Genetics, Faculty of Natural Sciences, Aarhus University. The work was carried out in the laboratory of Elena Conti at the Max Planck Institute of Biochemistry, Martinsried, Germany.

This summary was prepared by the PhD student.

Time: Friday, 12 January 2024  at 13:00

Zoom aarhusuniversity.zoom.us/j/62160337012

Title of PhD thesis: Isolation and Characterisation of Yeast Nuclear Messenger Ribonucleoproteins.
Contact information: Fabien Bonneau, e-mail: bonneau@biochem.mpg.de, tel.: +49 8985783626

Members of the assessment committee:
Professor   Françoise Stutz, Department of Cell Biology, Geneva University, Switzerland

Professor   Peter Brodersen, Department of Biology, Copenhagen University, Denmark

Professor   Ditlev Egeskov Brodersen (chair), Department of Molecular Biology and Genetics, Aarhus University, Denmark

Main supervisor:
Professor   Torben Heick Jensen, Department of Molecular Biology and Genetics, Aarhus University, Denmark

Language: The PhD dissertation will be defended in English

The defence is public.
The PhD thesis is available for reading at the Graduate School of Natural Sciences/GSNS,

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