P-type ATPases are a certain class of membrane proteins which maintains ion homeostasis and electrochemical gradients by actively translocating cations across cellular membranes. During her Ph.D. studies, Henriette has worked on two different P-type ATPases: a calcium-transporting ATPase (SERCA) and a copper-transporting ATPase (CopA), both essential for all domains of life. By employing X-ray crystallographic methods and molecular dynamics simulations, Henriette’s aim was to structurally characterize these two P-type ATPases in order to increase our current understanding of how they function at the atomistic level and to lay the groundwork for how they may be targeted by novel drugs in the future.

The PhD degree was completed at the Department of Molecular Biology and Genetics, Science and Technology, Aarhus University.

This résumé was prepared by the PhD student.

Time: Wednesday 28 January 2015 at 13.15
Place: Building 1532, room 122, Lecture Theatre G2, Department of Mathematics, Aarhus University.
Title of dissertation: Elucidating Functional Aspects of P type ATPases: Structural Studies of SERCA1a and LpCopA
Contact information: Henriette Elisabeth Autzen, e-mail: henriette@mbg.au.dk
Members of the assessment committee:
Professor Kresten Lindorff-Larsen, Department of Biology, University of Copenhagen, Denmark
Professor Raimund Dutzler, Institute of Biochemistry, University of Zürich, Switzerland
Professor Finn Skov Pedersen (chair), Department of Molecular Biology and Genetics, Aarhus University
Main supervisor:
Professor Poul Nissen, DANDRITE – Nissen Group, Department of Molecular Biology and Genetics, Aarhus University
Language: The PhD dissertation will be defended in English.

The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1521, room 112, 8000 Aarhus C.