During his studies, Jonas Lindholt Gregersen researched the sodium-potassium pump, a protein present in all mammalian cells. The pump is present in the plasma membrane and maintains salt concentrations by transporting sodium out of and potassium into the cell. Jonas Lindholt Gregersen’s studies were bipartite and was about 1) investigation of the sodium-potassium pump’s interaction with cardiotonic steroids, and 2) reconstitution of the sodium-potassium pump in so called nanodiscs, a versatile tool for membrane protein investigation.

The new research findings contribute to a better understanding the structural interaction of the sodium-potassium pump with cardiotonic steroids and provide a means of further investigation using the nanodisc tool, both functionally and structurally.

The PhD degree was completed at the Department of Molecular Biology and Genetics, Science and Technology, Aarhus University.

This résumé is prepared by the PhD student.

Time: Monday 26 January 2015 at 14.15
Place: Building 1593, room 012, iNANO Lecture Theatre, Department of iNANO, Arhus University
Title of dissertation: Characterisation of the Mammalian Na+, K+-ATPase – Cardiotonic steroid interaction and nanodisc reconstitution
Contact information: Jonas Lindholt Gregersen, e-mail: lindholt@post.au.dk, tel.: +45
Members of the assessment committee:
Assistant professor Nanna Macaulay, Department of Cellular and Molecular Medicine, University of Copenhagen
Professor Karl-Peter Hopfner, Department of Biochemistry, LMU University of Münich
Professor Claus Oxvig, Department of Molecular Biology and Genetics, Aarhus University (chair)
Main supervisor:
Professor Poul Nissen, Department of Molecular Biology and Genetics, Aarhus University
Co-supervisor:
Assistant Professor Natalya U. Fedosova, Department of Biomedicine, Aarhus University
Language: The PhD dissertation will be defended in English.

The defence is public.

The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1521, room 112, 8000 Aarhus C.