During her PhD studies, Mariam Gamaleldin researched the newly synthesized proteins in the hippocampus, a brain structure implicated in our capacity to form memories. The brain needs a fresh supply of proteins to strengthen the connections between neurons and form long-lasting memories. Mariam Gamaleldin used a new set of tools and techniques to determine which proteins are made during the building of these neuronal connections.

The preliminary research findings contribute to the understanding of how connections between neurons grow and possibly provide a hint into the mechanism of memory formation as well.

The PhD study was completed at the Department of Molecular Biology and Genetics, Faculty of Natural Sciences, Aarhus University.

This summary was prepared by the PhD student.

Time: Thursday, 20 May 2021 at 9.30
The PhD defence will be held online. To receive a link to the event, please send an e-mail to Sadegh Nabavi (snabavi@dandrite.au.dk).

Title of PhD thesis: Identification of changes in the de novo proteome underlying the strengthening of synaptic connections

Contact information: Mariam Gamaleldin, e-mail: mariam.gamaleldin@dandrite.au.dk, tel.: +45 61685990

Members of the assessment committee:

Professor Joris De Wit, VIB-KU Leuven Center for Brain & Disease Research, Belgium

Principal Investigator Àlex Bayés, Biomedical Research Institute Sant Pau, Spain

Professor Finn Skou Pedersen (chairman), Department of Molecular Biology and Genetics, Aarhus University, Denmark

Main supervisor:
Associate Professor Sadegh Nabavi, Department of Molecular Biology and Genetics, Aarhus University, Denmark

Co-supervisor:
Professor Anders Nykjær, Department of Biomedicine, Aarhus University, Denmark

The defence is public.
Due to the coronavirus situation, the PhD thesis will not be available for reading at the offices of the PhD administration. Instead, interested parties may send an e-mail to gradschool.nat@au.dk to receive a digital copy of the PhD thesis. Please note, it may in certain cases be necessary to make an individual arrangement to read the PhD thesis.