Human cells have an intrinsic ability to defend themselves against virale infections. Mikkel Ibsen has during his Ph.D. studies conducted research on a family of human antiviral proteins called the OAS family.

By purifying OAS proteins Mikkel Ibsen has been able to study their biochemical and structural features. The research results have contributed to establishing an antiviral mechanism of OASL and a structural understanding of the protein. Furthermore, the research have contributed to redefine the role of OAS3.

The PhD degree was completed at the Institute for Molecular Biology and Genetics, Science and Technology, Aarhus University.

Time: Friday 10 October 2014 at 13.00
Place: 1523-318, Fysisk Auditorium, Ny Munkegade, 8000 Aarhus C
Title of dissertation: Novel roles of the OAS family in antiviral defense
Contact information: Mikkel Ibsen, e-mail: msi05@mb.au.dk, tel.: +45 51446612
Members of the assessment committee:
Professor Dr. med. Otto Haller, Institute of Virology, Universitäts Klinikum, Germany
Dr. Atlanta Cook, Wellcome Trust Centre for Cell Biology, University of Edinburgh, United Kingdom
Associate professor Ditlev Brodersen (chair), Department of Molecular Biology and Genetics, Aarhus University
Main supervisor:
Associate professor Rune Hartmann, Department of Molecular Biology and Genetics, Aarhus University
Language: The Ph.D. dissertation will be defended in English.

The defense is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1521, room 112, 8000 Aarhus C.