Programmed cell death (apoptosis) is a central process during embryonic development. Furthermore, it removes damaged and superfluous cells from our body. Misregulation of apoptosis is also involved in several diseases such as cancer and neurodegenerative diseases. Several of the genes regulating apoptosis was first identified in the nematode Caenorhabditis elegans.

In her PhD studies, Tine Hørning Morthorst has investigated how the protein dynein light chain 1 regulates apoptosis by using C. elegans as a model organism. The study has identified two independent pathways through which dynein light chain 1 regulates apoptosis and contribute to the understanding of apoptosis is regulates in sick and healthy cells.

The PhD degree was completed at the Department of Molecular Biology and Genetics, Science and Technology, Aarhus University.

This résumé is prepared by the PhD student.

Time: Thursday 24 September 2015 at 13.00
Place: Building 1253, room 317, William Scharff Lecture Theatre, Lakeside Lecture Theatres, Aarhus University
Title: Tissue Specific Roles of Dynein Light Chain 1 in Regulating Germ Cell Apoptosis in Ceanorhabditis elegans
Contact info: Tine Hørning Morthorst, e-mail: tinehm@mbg.au.dk, tlf.: 22821966
Evaluation committee:
Professor Victoria Allan, Faculty of Life Sciences, University of Manchester, England
Professor Hilde Nilsen, Department of Clinical Molecular Biology, University of Oslo, Norway
Associate Professor Anni Hangaard Andersen (chairman), Department of Molecular Biology and Genetics, Science and Technology, Aarhus University
Main supervisor:
Associate Professor Tinna V. Stevnsner, Department of Molecular Biology and Genetics, Science and Technology, Aarhus University
Co-supervisor:
Senior Advisor Anders Olsen, Department of Molecular Biology and Genetics, Science and Technology, Aarhus University
Language: The defense will be held on English

The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1521, room 112, 8000 Aarhus C