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With a grant from the Independent Research Fund Denmark’s Sapere Aude programme, Peter Refsing Andersen from the Department of Molecular Biology and Genetics and AIAS, Aarhus University, will uncover the strategies used by DNA parasites to evade the genomic defence mechanisms. Photo: Lisbeth Heilesen

2019.11.19 | Grant

Revealing how genes fight each other for space in the genome

Spread of DNA parasites can destroy important genes, so all forms of life have evolved genome defence mechanisms to keep the parasites in check. With a grant of DKK 6.2 mio. from the Independent Research Fund Denmark’s Sapere Aude programme, Peter Refsing Andersen from the Department of Molecular Biology and Genetics and AIAS, Aarhus University,…

A functional link between nuclear RNA decay and transcriptional control by the Polycomb Repressive Complex 2. In the absence of PAXT-mediated RNA decay, nuclear pA+ transcripts are stabilised. Excess RNA binds and out-titrates PRC2 from chromatin, and the interaction between complex subunits is disrupted. Normal PRC2-repressed loci show decreased H3K27me3 levels and correlates with increased an increase in transcription. Figure: Will Garland/AU

2019.11.15 | Research

RNA regulation is crucial for embryonic stem cell differentiation

Nuclear RNA levels are kept in check by RNA decay factors. Now, researchers at Aarhus and Copenhagen Universities show that an excess of RNA in the nucleus can have negative effects on a crucial regulator of stem cell differentiation.

Bjørn Panyella Pedersen. Photo: AU Photo

2019.11.13 | People

Bjørn Panyella Pedersen selected as EMBO Young Investigator

MBG Group Leader Bjørn Panyella Pedersen is one of 27 researchers that have been selected to join the Young Investigators Programme of the European Molecular Biology Organization (EMBO) in 2019. For the coming four years, he will join this prestigious network of young scientists.

Assistant Professor Lasse Sommer Kristensen, Department of Molecular Biology and Genetics, Aarhus University. Photo: Lundbeckfonden

2019.11.06 | Grant

Researcher will improve diagnoses for cancer

More knowledge about so-called circular RNA could improve the ability to make more accurate diagnoses and predict how the individual patient will respond to certain types of cancer drugs. Lasse Sommer Kristensen from the Department of Molecular Biology and Genetics, AU, receives DKK 10 million from the Lundbeck Foundation for the project.

With this grant, Ulf Andersson Vang Ørom (to the right) hopes to identify uncharacterized RNA modifications with a role in splicing and cancer and in the long term use this knowledge to develop drugs targeted against RNA modifications. Photo: Lisbeth Heilesen.

2019.10.23 | Grant

Ulf Andersson Vang Ørom receives the Lundbeck Foundation's Ascending Investigator grant of DKK 5 million

Ulf Andersson Vang Ørom from the Department of Molecular Genetics, AU, receives DKK 5 mio. (EUR 670,000) from the Lundbeck Foundation and their new grant scheme aimed at experienced researchers for projects with potential for significant scientific findings within biomedical research. The aim of the project is to identify RNA modifications with a…

The fruit fly (<em>Drosophila melanogaster</em>) is a fantastic model organism, which has contributed to major scientific breakthroughs (photo: Torsten Nygård Kristensen, Aalborg University)
Up to three-quarters of all identified human disease genes are found in a similar version in the fruit fly, and there is also a high degree of similarity between the nervous system of humans and insects (photo: Aalborg University)

2019.10.09 | Research

Fruit flies help in the development of personalised medicine

It is common knowledge that there is a connection between our genes and the risk of developing certain diseases. In a study on fruit flies, researchers from Aarhus University and Aalborg University have found that gene mapping can also be used to predict response to a given treatment. This knowledge is crucial for the development of personalised…

Photo: Colourbox

2019.10.03 | Research

Flood-tolerant crops for the future climate

A flood can ruin a potato harvest in just 24 hours. However, by understanding the plant's defence mechanisms against flooding, it is possible to create more flood-tolerant crops that can withstand flooding. An international research team with the participation of Associate Professor Kim Hebelstrup from the Department of Molecular Biology and…

In an international collaboration, researchers from Aarhus University have now presented a completely new, ground-breaking model for the integration and incorporation of cholesterol into cells. Figure: Bjørn Panyella Pedersen/AU.

2019.09.19 | Research

Rethinking how cholesterol is integrated into cells

Cholesterol is best known in connection with cardiovascular disease, but cholesterol is also vital for many fundamental processes in the body. In an international collaboration, researchers from Aarhus University have now presented a completely new, ground-breaking model for the integration and incorporation of cholesterol into cells, with great…

Based on violet carrots, Danish researchers and a Danish company will make it possible to replace more artificial colours in food with natural colours based on vegetables. The Innovation Fund has invested almost DKK 15 million (around Euro 2 million) in the project (photo: Henrik Brinch-Pedersen/AU)

2019.09.13 | Knowledge exchange, Grant

New research project may pave the way for a farewell to artificial colours in food

Based on violet carrots, Henrik Brinch-Pedersen from the Department of Molecular Biology and Genetics and his collaborators will make it possible to replace more artificial colours in food with natural colours based on vegetables. The Innovation Fund has invested almost DKK 15 million (around Euro 2 million) in the project.

The four molecular biologists behind the spin-out company omiics (from left): Yan Yan, Morten Venø, Junyi Su and Susanne Venø (photo: Kenneth Frydensbjerg)

2019.09.06 | Research, Knowledge exchange

Molecular biologists are successful with spin-out company

Four molecular biologists from Aarhus University have started a spin-out company that offers to identify very small differences between biological samples with a special technique. The researchers build on the experience they gained when they were students and postdocs at the Department of Molecular Biology and Genetics/iNANO with a special…

Microscopy image of an entire fruit fly (Drosophila melanogaster; body outline in green) with a protein central to the smuggling route (Nxf3) shown in red. Image Credit: Daniel Reumann, IMBA.

2019.08.08 | Research

Smuggling route for cells protects DNA from parasites

An international research team has now uncovered new insight into how safety mechanisms keep genetic parasites in check so that they do not damage the genome. In the long term, the results can help to understand and remedy some of the genetic problems in humans, such as low fertility.

Confocal microscopy images showing NICK4-GFP translocation to the nucleus upon perception of nod factors in Lotus japonicus roots. Image: Marcin Nadzieja/AU

2019.07.31 | Research

Scientists identified a new signaling component important for plant symbiosis

A proteomics-based protein-protein interaction study has led to the discovery of proteins that interact with a legume receptor that mediates signal transduction from the plasma membrane to the nucleus. This shows how symbiotic signals from symbiotic bacteria are transmitted upon perception, ultimately leading to their accommodation within the host…

2019.06.28 | Awards

The receipients of the Kjeld Marcher PhD Award 2019

Sofie H. Lautrup and Oskar Franch were awarded the Kjeld Marcker PhD Award 2019 at the annual meeting of the Department of Molecular Biology and Genetics on Friday 28 June 2019.

2019.06.28 | Awards

Teachers of the year

Pia Møller Martensen and Søren Kirk Amstrup were awarded the prizes as teacher of the year and the student teacher of the year 2019, respectively, at the Annual Meeting of the Department of Molecular Biology and Genetics on Friday 28 June 2018.

On the raw electron micrographs (A), one can find the individual protein molecules (green boxes). By taking an average of thousands of such similarly oriented particles, one can get sharp two-dimensional images (B), from which one can calculate the protein's three-dimensional structure (C). Finally, one can interpret this result by building a model of the protein (D). Image: Milena Timcenko.

2019.06.27 | Research

Groundbreaking cryo-electron microscopy at Aarhus University reveals the first structures of a protein that maintains cell membranes

Using cutting-edge electron microscopy, researchers from Aarhus University have determined the first structures of a lipid-flippase. The discoveries provide a better understanding of the basics of how cells work and stay healthy, and can eventually increase our knowledge of neurodegenerative diseases such as Alzheimer’s.

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