Peer-reviewed articles

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Latest peer-reviewed publications at MBG

Pitfield, J., Christiansen, M. P. V. & Hammer, B. (2026). Active Δ-learning with universal potentials for global structure optimization. Physical Chemistry Chemical Physics, 28(1), 912-926. https://doi.org/10.1039/d5cp04302f

Zhang, H., Windhorst, A., Bornhofen, E., Tulpova, Z., Novak, P., Macas, J., Simkova, H., Nadzieja, M., Kim, J. M., Cram, D., Cao, Y., Konkin, D. J. F., Sass, O., Welna, G., Himmelbach, A., Mascher, M., Link, W., Kwon, S.-J., Yang, T.-J. ... Jayakodi, M. (2026). Allelic variation at a single locus distinguishes spring and winter faba beans. Nature Genetics, 58(3), 655-663. https://doi.org/10.1038/s41588-026-02524-y

Kaas, M., Dinesen, S. B., Ahlgreen, O., Madsen, P., Mølgaard, S., Dalby, A., Gustafsen, C., Olsen, D., Duan, J., Vilstrup, J., Lende, J., Nordestgaard, S., Zayats, T., Knappskog, P. M., Johansson, S., Neckelmann, G., Franke, B., Thirup, S., Børglum, A. ... Skeldal, S. (2026). A low frequency damaging SORCS2 variant identified in a family with ADHD compromises receptor stability and quenches activity. Molecular Psychiatry, 31(3), 1311-1324. https://doi.org/10.1038/s41380-025-03242-3

Hopkinson, A. T., Wilson, A. M., Pitfield, J., Muiña, A. T., Rácz, R., Mifsud, D. V., Herczku, P., Lakatos, G., Sulik, B., Juhász, Z., Biri, S., McCullough, R. W., Mason, N. J., Scavenius, C., Hornekær, L. & Ioppolo, S. (2026). An interstellar energetic and non-aqueous pathway to peptide formation. Nature Astronomy, 10(4), 531-539. https://doi.org/10.1038/s41550-025-02765-7

D'Alessio, A. M., Yuan, H., Soria, L. R., Hansen, S. B., Boffa, I., Arena, P., Attianese, B., O'Sullivan, M., Cullinan, N., Pang, L., van Aalten, D. M. F., Brunetti-Pierri, N. & Lynch, S. A. (2026). An OGT Missense Variant With Impaired Enzyme Activity in a Child With Severe Developmental Delay and Hepatoblastoma. American Journal of Medical Genetics, Part A, 200(2), 502-510. https://doi.org/10.1002/ajmg.a.64275

Jensen, K. T., Viana de Almeida, A. C., Rönning, S., Karlander, M., Nielsen, N. S., Thøgersen, I., Malm, M., Andersen, G. R., Enghild, J. J., Rockberg, J. & Harwood, S. L. (2026). Antagonist nanobodies prevent protease inhibition by CD109. Journal of Biological Chemistry, 302(3), Article 111187. https://doi.org/10.1016/j.jbc.2026.111187

Rast, J. E., Rosso, A. L., James, B. D., Underwood, J. F. G., Bergstedt, J., Ahlqvist, V. H., Grove, J., Fang, F., Goldstein, N. D., Vivanti, G., Levine, S. Z., Nordström, A., Schendel, D., Lyall, K., Nordström, P., Ballin, M., Stafford, J., Naj, A. C., Lee, B. K. & LEGENNDS Consortium (2026). Association of neurodevelopmental conditions with Alzheimer's disease and related dementias and Parkinson's disease. The Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, 81(4), Article glaf281. https://doi.org/10.1093/gerona/glaf281

Samanta, A., Malle, M. G., Tsang, E., Omer, M., Skaanning, M. K., Youssef, S., Kjems, J. & Gothelf, K. V. (2026). Bacteriophage-Mimetic DNA Origami Needle for Targeted Membrane Penetration and Cytosolic Cargo Delivery. Advanced Science, 13(10), Article e12844. https://doi.org/10.1002/advs.202512844

Rasmussen, A. M., Bouchard-Côté, A. & Pedersen, J. S. (2026). bayesReact: expression-coupled regulatory motif analysis detects microRNA activity across cancers, tissues, and at the single-cell level. Nucleic Acids Research, 54(4), Article gkag072. https://doi.org/10.1093/nar/gkag072

Kjær, M. B., Jørgensen, A. G., Fjelstrup, S., Dupont, D. M., Bus, C., Oversoe, S. K., Kelsen, J., Kjems, J. & Grønbæk, H. (2026). Biomarker-directed aptamer panels for diagnosis and differentiation of neuroendocrine tumors. Journal of Neuroendocrinology, 38(3), Article e70146. https://doi.org/10.1111/jne.70146

Andersen, L., Lindskrog, S. V., Nordentoft, I., Frydendahl, A., Nors, J., Henriksen, T. V., Rasmussen, M. H., Iversen, L. H., Gotschalck, K. A., Jensen, J. B., Dyrskjøt, L., Andersen, C. L. & Birkbak, N. J. (2026). Cell-Free DNA-Derived Immune Cell Ratios Uncover Cancer-Associated Systemic Changes. Cancer Research Communications, 6(4), 811-820. https://doi.org/10.1158/2767-9764.CRC-25-0747

Yan, K., Stanley, M., Raimi, O., Ferenbach, A. T., Dorfmueller, H. C. & van Aalten, D. M. F. (2026). Cell wall target fragment discovery using a low-cost, minimal fragment library. FEBS Letters. Advance online publication. https://doi.org/10.1002/1873-3468.70281

Utley, D., Budnick, A., Radutoiu, S. & Sederoff, H. (2026). Circular RNAs in Lotus japonicus Responses to Nutrient Supply and Mesorhizobium Symbiosis. Plant, Cell and Environment. Advance online publication. https://doi.org/10.1111/pce.70496

Gázquez-Gutiérrez, A., Chin, P., Peris, G., Gordon, K., Marchante, P. G., Witteveldt, J., Tristán-Ramos, P., Rouvière, J. O., Knol, L. I., Ivens, A., López-Onieva, L., Estévez, A. M., Garland, W., Jensen, T. H., Heras, S. R. & Macias, S. (2026). Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8. Nucleic Acids Research, 54(5), Article gkag190. https://doi.org/10.1093/nar/gkag190

Lee, H., Ko, K., Kim, S., Lee, G., Kim, S., Lee, J., Song, D. Y., Bong, G., Han, J. H., Lee, J., Kim, Y. R., Lee, Y., Kim, E., Børglum, A. D., Grove, J., Kim, S. H., Sun, W., Yoo, H. J. & An, J. Y. (2026). Co-occurrence of rare variants implicates gene pairs in cytoskeletal pathways and is associated with increased severity in autism spectrum disorder. Genome Biology, 27(1). https://doi.org/10.1186/s13059-026-04041-x

Marzookian, K., Aliakbari, F., Hourfar, H., Sabouni, F., Otzen, D. E. & Morshedi, D. (2026). Corrigendum to “The neuroprotective effect of human umbilical cord MSCs-derived secretome against α-synuclein aggregates on the blood-brain barrier” [Int. J. Biol. Macromol. Volume 290 (2025), 140387] (S0141813025009365), (10.1016/j.ijbiomac.2025.140387). International Journal of Biological Macromolecules, 337, Article 149909. https://doi.org/10.1016/j.ijbiomac.2025.149909

Khachadourian, V., Anderson, M., Arildskov, E. S., Grove, J., Reichenberg, A., Sandin, S., Schendel, D., Hansen, S. N., Croen, L. A. & Janecka, M. (2026). Cross-Setting Replication of the Associations Between Maternal Health and Autism. Journal of the American Academy of Child and Adolescent Psychiatry. Advance online publication. https://doi.org/10.1016/j.jaac.2025.11.009

Pedersen, K., Green, K., Kristoffersen, E. L., Schinkel, T., Hansen, A. G., Palarasah, Y., Rovsing, A. B., Andersen, E. S., Valero, J., Civit, L., Laursen, N. S., Troldborg, A., Degn, S. E. & Thiel, S. (2026). Curbing Autoimmunity: A New Fab Fragment Targeting CD40-CD40L Halts B-Cell Activation and Differentiation. European Journal of Immunology, 56(2), Article e70158. https://doi.org/10.1002/eji.70158

Kofod Petersen, A., Spin-Neto, R., Villesen, P. & Staun Larsen, L. (2026). Curvature-based 3D dental comparison to identify trauma-induced surface changes in human teeth: a forensic comparison study. Journal of Forensic Odonto-Stomatology, 43(3), 49-58.

Goto, T., Andersen, K. R., Bamba, M., Sato, S., Sugawara, M., Minamisawa, K., Kawaguchi, M., Stougaard, J. & Kawaharada, Y. (2026). Cyclophilin A-mediated cis/trans isomerization modulates RIN4 to control intracellular rhizobial infection in legumes. New Phytologist. Advance online publication. https://doi.org/10.1111/nph.71147

Møhlenberg, M., Jørgensen, S. E., Marije van der Sluis, R., Zillinger, T., Hinke, D. M., Hollensen, A. K., Hansen, A. L., Hausfater, P., Gorochov, G., Tubach, F., Ghosn, J., Laouenan, C., Storgaard, M., Holm, C. K., Su, H., Pérez de Diego, R., Pujol, A., Zhang, S.-Y., Zhang, Q. ... COVID Human Genetic Effort (2026). Defective RNA Polymerase III sensing of mitochondrial DNA in pulmonary epithelial cells impairs type I IFN immunity to SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America, 123(12), Article e2522111123. https://doi.org/10.1073/pnas.2522111123

AlZaim, I., Hassan, M. N., Schröter, M., Mannino, L., Dragicevic, K., Sjogaard, M. B., Festa, J., Dokshokova, L., Weinbrenner, S., Tardajos Ayllon, B., Hansen, B., Rasmussen, R. K., Christensen, J. N., Wagman, O., Schipper, R., Cai, M., Dheedene, W., Bohn, A. B., Farup, J. ... Kalucka, J. (2026). Defining the vascular niche of human adipose tissue across metabolic states. Nature Metabolism, 8(3), 722-740. https://doi.org/10.1038/s42255-026-01475-2

Kuhn, C. C., Chand, M. K., Todesca, S., Williams, K., Keidel, A., Garland, W., Jensen, T. H. & Conti, E. (2026). Direct coupling of the human nuclear exosome adaptors NEXT and PAXT with transcription termination and processing machineries. Nucleic Acids Research, 54(4), Article gkag088. https://doi.org/10.1093/nar/gkag088

López Hernández, M., Scavenius, C., Otzen, D. E. & Pedersen, J. S. (2026). Divergent effects of anionic surfactants on laundry enzymes: Structural stability, activity modulation, and self-cleavage mechanisms. International Journal of Biological Macromolecules, 335(1), Article 149069. https://doi.org/10.1016/j.ijbiomac.2025.149069

Myrup Holst, C., Esperon-Abril, I., Bryske Juhl, F., Jakobsgaard, J. E., Kristiansen, J. B., Vissing, K. & Stevnsner, T. (2026). Effect of prolonged voluntary wheel running on oxidative stress and defence mechanisms in cortex and hippocampus of healthy female rats. Experimental Physiology, 111(2), 449-463. https://doi.org/10.1113/EP092815

Clark, EL., Amaral, A., Baranasic, D., Barta, E., Cartick, G., Chua, P., Espinosa-Carrasco, J., Fang, L., Fischer, D., Foissac, S., Gillard, G., Giuffra, E., Hartwig, T., Heil, KF., Henkel, C., Kadarmideen, HN., Klingström, T., MacHugh, DE., Murdoch, BM. ... Larzul, C. (2026). Establishing the ELIXIR Domestic Animals Genome and Phenome Community. F1000Research, 15(ELIXIR)(339), Article 339. https://doi.org/10.12688/f1000research.177500.1

Aliakbari, F., Rahmani, M., Marzookian, K., Boroujeni, N. N., Alikhanian, A., Ghasemi, F., Otzen, D. E. & Morshedi, D. (2026). Exosomes as Advanced Nanocarriers: Overcoming the Blood-Brain Barrier for Targeted Therapeutic Delivery in Neurodegenerative Diseases. Current drug delivery. Advance online publication. https://doi.org/10.2174/0115672018430706251211094801

Winther, K. G., Schneider, J., Haas, G., Christensen, A. H., Goyal, S., Luo, W., Wei, Z., Liu, J., Kjøge, K., Enghild, J. J., Meignin, C., Silverman, N., Cai, H., Imler, J. L. & Hartmann, R. (2026). FADD is recruited to activated STING oligomers to initiate caspase-mediated NF-κB activation in Drosophila melanogaster. EMBO Journal, 45(9), 2965-2990. https://doi.org/10.1038/s44318-026-00761-9

Walpole, S., Santiago-Vela, M. I., Birkedal, U., Hong, Z., Ros, X. B. D., van Overeem Hansen, T. & Wadt, K. A. W. (2026). Functional Analysis and Clinical Data Reclassify the DICER1 c.4206+1G>C Variant, Leading to Exon 22 Skipping, as Likely Pathogenic. Clinical Genetics, 109(5), 931-936. https://doi.org/10.1111/cge.70110

Kretsch, R. C., Albrecht, R., Andersen, E. S., Chen, H.-A., Chiu, W., Das, R., Gezelle, J. G., Hartmann, M. D., Höbartner, C., Hu, Y., Jadhav, S., Johnson, P. E., Jones, C. P., Koirala, D., Kristoffersen, E. L., Largy, E., Lewicka, A., Mackereth, C. D., Marcia, M. ... Kryshtafovych, A. (2026). Functional relevance of CASP16 nucleic acid predictions as evaluated by structure providers. Proteins: Structure, Function and Bioinformatics, 94(1), 51-78. https://doi.org/10.1002/prot.70043

Lildballe, D. L., Huno, M. R., Ridder, L. O. R., Balle, C. M., Drue, S. O., Berglund, A., Dunø, M., Bak, E. N., Viuff, M. H., Rasmussen, L. S. & Gravholt, C. H. (2026). Genetic diagnosis of CYP21A2-related CAH: adaptive sampling long-read sequencing is an accurate and scalable solution. European Journal of Human Genetics, 34(4), 535-542. https://doi.org/10.1038/s41431-026-02019-8

Astono, J., Jørgensen, A. G., Bus, C., Nielsen, S. D. H., Kjems, J. & Sundekilde, U. K. (2026). Global protein profiling of human milk using pre-enriched RNA-sequence libraries. Scientific Reports, 16(1), Article 11827. https://doi.org/10.1038/s41598-026-41374-w

Harvey, A. C., Bølcho, U., Main, B., Nykjær, A., Holm, M. M., Nissen, P., Kjærgaard, M. & Poulsen, H. (2026). Grin2b 3’UTR is necessary for synaptic plasticity and spatial learning. PNAS, 123(8), Article e2518282123. https://doi.org/10.1073/pnas.2518282123

Mabruk, Z., Bullock, E., Xiao, X., Guo, J., Zhu, X., Gómez-Cuadrado, L., Oxvig, C., Mallon, E., Ammar, A., Malty, A., Pennel, K., Edwards, J. & Brunton, V. G. (2026). High Expression of PAPP-A Predicts Poor Outcomes in Oestrogen Receptor-Positive Breast Cancer Patients. Cancer Medicine, 15(4), e71815. https://doi.org/10.1002/cam4.71815

Naik, S., Fedosov, S. N., Mahalle, N., Narawade, S., Nexo, E. & Heegaard, C. W. (2026). High oral doses of vitamin B₁₂ in early pregnancy improve B₁₂ status of mother and child irrespective of subsequent supplementation a longitudinal study in B₁₂ insufficient Indian women supplemented with either milk, vitamin pills, or placebo. Biochimie. Advance online publication. https://doi.org/10.1016/j.biochi.2026.01.014

Chrenková, A., Nashier, P., Madsen, C. L., Singh, M., Nielsen, J., Otzen, D. E., Enghild, J. J., Macek, B., Skjerning, R. B. & Brodersen, D. E. (2026). Homologous HipA-like kinases are controlled by internal translational initiation and genetic organisation. FEBS Letters, 600(3), 356-369. https://doi.org/10.1002/1873-3468.70234

Rattan, S. (2026). Hormesis and Hormetins as Drugs for Health and Longevity. In Supplements and Drugs for Healthy Longevity (pp. 461-468). Springer, Cham.

Yamamoto, S., Nakajima, R., Hirai, Y., Kawamura, Y. K., Makita, Y., Kitazawa, T., Kimura, M. & Kitazawa, Y. (2026). Hydroxylated iodinated boron clusters: a tunable platform for enhanced membrane transport and biocompatibility. Chemical Communications, 62(3), 879-882. https://doi.org/10.1039/d5cc04085j

Svraka, L., Andersen, A. S., Touborg, T., Emmanuel, T., GK, U., Kadarmideen, H., Bertelsen, T., Vestergaard, C. & Johansen, C. (2026). IL-17 Cytokines Induce IκBζ in Dermal Fibroblasts to Promote Pro-Inflammatory Gene Expression in Psoriasis. International Journal of Molecular Sciences , 27(3), Article 1297. https://doi.org/10.3390/ijms27031297

Kristjánsdóttir, N., Thorsen, K., Birkbak, N. J. & Dyrskjøt, L. (2026). Immune profiling of T cells: A comparative analysis of single-cell TCR sequencing using 10X Genomics and Parse Biosciences platforms. Biochemistry and Biophysics Reports, 46, Article 102592. https://doi.org/10.1016/j.bbrep.2026.102592

Georgaki, D., Canibe, N., van der Heide, M. E., Foldager, L., Poulsen, C. H., Mejldal, R., Velayudhan, D., Nørgaard, J. V. & Højberg, O. (2026). Impact of 1,2-α-L-fucosidase on pig enteric methane production and growth performance. Animal Microbiome, 8(1), Article 30. https://doi.org/10.1186/s42523-025-00487-9

Sørensen, M. T., Dalgaard, T. S., Kjærup, R. B., Mandrioli, D. & Foldager, L. (2026). Influence of glyphosate in feed on egg hatchability and health of chicks and breeder hens. British Poultry Science. Advance online publication. https://doi.org/10.1080/00071668.2026.2615732

Gordon, M., Akyol, T. Y., Amos, B., Andersen, S. U. & Williams, C. (2026). KeySDL: sparse dictionary learning for keystone microbe identification from steady-state observations using a dynamical-systems model. BioData Mining, 19(1), 18. Article 18. https://doi.org/10.1186/s13040-026-00527-3

Rattan, S. (2026). Lifespan stops at death, but when does healthspan stop? Biogerontology, 27(2), 78. Article 78. https://doi.org/10.1007/s10522-026-10424-1

Juhl, A. D., Sprenger, R. R., Modzel, M., Halder, S., Szomek, M., Akkerman, V., Xu, Y., Heegaard, C. W., Ejsing, C. S., Covey, D. F. & Wüstner, D. (2026). Live-Cell Imaging and Lipidomics of Low-Density Lipoprotein Containing Intrinsically Fluorescent Cholesteryl Esters. Analytical Chemistry, 98(9), 7069-7083. https://doi.org/10.1021/acs.analchem.5c05064

Neis, K., Civit Pitarch, L., Pedersen, K., Schachtner, M., Wengel, J., Wagner, R., Thiel, S., Kjems, J. & Valero Moreno, J. (2026). Lock, Protect, and Bind: In Vitro Selection of Locked Nucleic Acid-Modified Aptamers Using a Mutant T7 RNA Polymerase. Small Structures, 7(3), Article e202500677. https://doi.org/10.1002/sstr.202500677

Obsessive-Compulsive Disorder and Tourette Syndrome Working Group of the Psychiatric Genomics Consortium, Post-Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, Anxiety Disorders Working Group of the Psychiatric Genomics Consortium, Attention-Deficit/Hyperactivity Disorder (ADHD) Working Group of the Psychiatric Genomics Consortium, Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Eating Disorders Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Nicotine Dependence GenOmics (iNDiGO) Consortium, Brikell, I., Grove, J., Sonuga-Barke, E., Hübel, C., Larsen, J. T. & Petersen, L. V. (2026). Mapping the genetic landscape across 14 psychiatric disorders. Nature, 649(8096), 406-415. https://doi.org/10.1038/s41586-025-09820-3

Bergman, J., Bakarić, R. & Brčić-Kostić, K. (2026). Measures of gene indispensability reveal the parallelism between phylogeny and ontogeny. BioSystems, 261, Article 105710. https://doi.org/10.1016/j.biosystems.2026.105710

Vasilevsky, N. A., Toro, S., Matentzoglu, N., Flack, J. E., Mullen, K. R., Hegde, H., Gehrke, S., Whetzel, P. L., Shwetar, Y., Harris, N. L., Ngu, M. S., Alyea, G. L., Kane, M. S., Roncaglia, P., Sid, E., Thaxton, C. L., Wood, V., Abraham, R. S., Achatz, M. I. ... Haendel, M. A. (2026). Mondo: integrating disease terminology across communities. Genetics, 232(4). https://doi.org/10.1093/genetics/iyaf215

Goleva, S. B., Leu, C., Anne Feng, Y. C., Burstein, D., Venkatesh, S., Birnbaum, R., Rajagopal, V. M., Straub, P., Christensen, J., Bautista, J. F., Busch, R. M., Najm, I. M., Grove, J., Børglum, A. D., Voloudakis, G., Roussos, P., Smoller, J., Lal, D. & Davis, L. K. (2026). Multisite, Multiancestry Genome-Wide Association Study Meta-Analysis of Functional Seizure Disorder in a Hospital Sample of 675,680 Patients. Biological Psychiatry Global Open Science, 6(1), Article 100604. https://doi.org/10.1016/j.bpsgos.2025.100604

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