Aarhus University Seal / Aarhus Universitets segl

Torben Heick Jensen

Laboratory

Research

The regulation and fidelity of gene expression is of paramount importance for the maintenance and differentiation of all living organisms. Our laboratory studies the production and turnover of RNA in eukaryotic cells (S. cerevisiae, mouse and human) and its contribution to gene expression regulation at the post-transcriptional level. A main focus of the laboratory is to understand the molecular principles dictating the sorting of newly transcribed RNA into a productive pathway involving its packaging with protein and cellular transport vs. a destructive pathway leading to RNA turnover. 

Laboratory efforts can roughly be divided into four research topics:

· Delineation of nuclear human RNA decay pathways and their regulatory capacities

· Regulatory capacities of pervasive transcription

· snoRNA biogenesis, regulation and function

· Relationships between RNA synthesis and decay in S. cerevisiae

From 2005-2015 Torben Heick Jensen was heading the Danish National Research Foundation-funded ‘Centre for mRNP Biogenesis and Metabolism’. These, and other, efforts are now continued via funding from the European Research Council (ERC), the Danish Council for Independent Research, the Novo Nordisk foundation, the Lundbeck Foundation and the Danish Cancer Society.

News

24.02.2021 | Nyhed

Integrator: A guardian of the human transcriptome

In a joint collaboration, Søren Lykke-Andersen, Torben Heick Jensen et al. and German researchers have characterized a cellular activity that protects our cells from potentially toxic by-products of gene expression. This activity is central for the ability of multicellular organisms to uphold a robust evolutionary ‘reservoir’ of gene products.

Maria
Ross

24.02.2021 | Nyhed

Farewells

Good luck with future to PostDocs Maria Gockert and Ross Cordiner who recently left the lab. It was a pleasure having you around!

Good luck with your PostDocs Britt and Vaibhav.

23.09.2020 | Nyhed

News from the Lab

Welcome to the new students in the lab: Yujia Zhang is starting his PhD and we also have Nynke van Eijk og Berenice Horlacher starting undergrad projects in the lab. We also recently had to say goodbye to PhD student Britt Ardal and PostDoc Vaibhav Chikne.

16.06.2020 | Nyhed

How to keep the nucleus clean

RNA turnover in the nuclei of eukaryotic cells is controlled by the RNA exosome aided by numerous cofactors. Researchers at Aarhus University and Copenhagen University now show how two major nuclear exosome cofactors recognize their RNA targets to keep a clean nuclear environment. This is important for the health of our cells – and thus humans.