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Torben Heick Jensen

Laboratory

Research

The regulation and fidelity of gene expression is of paramount importance for the maintenance and differentiation of all living organisms. Our laboratory studies the production and turnover of RNA in eukaryotic cells (S. cerevisiae, mouse and human) and its contribution to gene expression regulation at the post-transcriptional level. A main focus of the laboratory is to understand the molecular principles dictating the sorting of newly transcribed RNA into a productive pathway involving its packaging with protein and cellular transport vs. a destructive pathway leading to RNA turnover. 

Laboratory efforts can roughly be divided into four research topics:

· Delineation of nuclear human RNA decay pathways and their regulatory capacities

· Regulatory capacities of pervasive transcription

· snoRNA biogenesis, regulation and function

· Relationships between RNA synthesis and decay in S. cerevisiae

From 2005-2015 Torben Heick Jensen was heading the Danish National Research Foundation-funded ‘Centre for mRNP Biogenesis and Metabolism’. These, and other, efforts are now continued via funding from the European Research Council (ERC), the Danish Council for Independent Research, the Novo Nordisk foundation, the Lundbeck Foundation and the Danish Cancer Society.

News

16.06.2020 | Nyhed

How to keep the nucleus clean

RNA turnover in the nuclei of eukaryotic cells is controlled by the RNA exosome aided by numerous cofactors. Researchers at Aarhus University and Copenhagen University now show how two major nuclear exosome cofactors recognize their RNA targets to keep a clean nuclear environment. This is important for the health of our cells – and thus humans.

16.06.2020 | Forskning

Regulering af RNA er afgørende for differentiering af stamceller

Nuclear RNA levels are kept in check by RNA decay factors. Now, researchers at Aarhus and Copenhagen Universities show that an excess of RNA in the nucleus can have negative effects on a crucial regulator of stem cell differentiation.

14.06.2019 | Forskning

New PostDocs

We are welcoming PostDocs Elena Burlacu, Upasana Saha and Vaibhav Chikne, who recently joined our lab. We also had to say goodbye to Mirelle Melko.

Professor Torben Heick Jensen receives DKK 60 million from the Novo Nordisk Foundation to establish the research center 'Exo-Adapt', which will determine how our cells sort genetic information. Photo: Lisbeth Heilesen.

11.01.2019 | Forskning

60 million DKK for basic biomedical research

Professor Torben Heick Jensen, Department of Molecular Biology and Genetics, Aarhus University, receives DKK 60 million (Euro 8 million) from the Novo Nordisk Foundation's Challenge Programme to establish the research center 'Exo-Adapt', which will determine how our cells sort genetic information.