Aarhus Universitets segl

Publications

2024

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2023

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2022

  • Bush JA, Meyer SM, Fuerst R, Tong Y, Li Y, Benhamou RI, Aikawa H, Zanon PRA, Gibaut QMR, Angelbello AJ, Gendron TF, Zhang YJ, Petrucelli L, Heick Jensen T, Childs-Disney JL, Disney MD. A blood-brain penetrant RNA-targeted small molecule triggers elimination of r(G4C2)exp in c9ALS/FTD via the nuclear RNA exosome. Proc Natl Acad Sci U S A., 2022, PubMed
  • Mengjun Wu, Manfred Schmid, Torben Heick Jensen & Albin Sandelin. Computational identification of signals predictive for nuclear RNA exosome degradation pathway targeting. NAR Genom Bioinform, 2022. PubMed.
  • Garland W, Müller I, Wu M, Schmid M, Imamura K, Rib L, Sandelin A, Helin K, Jensen TH. Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression. Mol Cell. 2022. PubMed.
  • Gerlach P, Garland W, Lingaraju M, Salerno-Kochan A, Bonneau F, Basquin J, Jensen TH, Conti E. Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome. Mol Cell. 2022, PubMed.
  • Rouvière JO, Lykke-Andersen S, Jensen TH. Control of non-productive RNA polymerase II transcription via its early termination in metazoans. Biochem Soc Trans., 2022, PubMed
  • Gockert M, Schmid M, Jakobsen L, Jens M, Andersen JS, Jensen TH. Rapid factor depletion highlights intricacies of nucleoplasmic RNA degradation. Nucleic Acids Res. 2022, PubMed.

2021

  • Tanu T, Taniue K, Imamura K, Onoguchi-Mizutani R, Han H, Jensen TH, Akimitsu N. hnRNPH1-MTR4 complex-mediated regulation of NEAT1v2 stability is critical for IL8 expression. RNA Biol. 2021 PubMed
  • Tudek A, Krawczyk PS, Mrocze k S, Tomecki R, Turtola M, Matylla-Kulinska K, Jensen TH, Dziembowski A. Global view on the metabolism of RNA poly(A) tails in yeast Saccharomyces cerevisiae. Nature Comm. 2021 PubMed
  • Turtola M, Manav CA, Kumar A, Tudek A, Krawczyk P, Mroczek S, Dziembowski A, Schmid M, Casañal A, Passmore L, Jensen TH. Three-layered control of nuclear mRNA poly(A) tail length in Saccharomyces cerevisiaeGenes and Dev. 2021 PubMed

  • Grenov A, Moss L, Edelheit S, Cordiner R, Schmiedel D, Biram A, Hanna J, Jensen TH, Schwartz S, Shulman Z. The germinal center reaction depends on RNA methylation and divergent functions of specific methyl-readers. Journal of Exp Med. 2021 PubMed

  • Lykke-Andersen S, Rouvière JO, Jensen TH. ARS2/SRRT: at the nexus of RNA polymerase II transcription, transcript maturation and quality control. Biochem Soc Trans. 2021 PubMed
  • Lykke-Andersen S, Žumer K, Molska EŠ, Rouvière JO, Wu G, Demel C, Schwalb B, Schmid M, Cramer P, Jensen TH. Integrator is a genome-wide attenuator of non-productive transcriptionMol. Cell 2021 PubMed

2020

  • Hollensen AK, Thomsen HS, Lloret-Llinares M, Kamstrup AB, Jensen JM, Luckmann M, Birkmose N, Palmfeldt J, Jensen TH, Hansen TB, Damgaard CK. circZNF827 nucleates a transcription inhibitory complex to balance neuronal differentiation. Elife 2020 Nov 11. PubMed
  • Dou Y, Barbosa I, Jiang H, Iasillo C, Molloy KR, Schulze WM, Cusack S, Schmid M, Le Hir H, LaCava J, Jensen TH. NCBP3 positively impacts mRNA biogenesis. Nucleic Acids Res. 2020 Sept 22. PubMed
  • Dou Y, Kalmykova S, Pashkova M, Oghbaie M, Jiang H, Molloy KR, Chait BT, Rout MP, Fenyö D, Jensen TH, Altukhov I, LaCava J. Affinity proteomic dissection of the human nuclear cap-binding complex interactome. Nucleic Acids Res. 2020 Sept 22. PubMed
  • Barra J, Gaidosh GS, Blumenthal E, Beckedorff F, Tayari MM, Kirstein N, Karakach TK, Jensen TH, Impens F, Gevaert K, Leucci E, Shiekhattar R, Marine JC. Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA NEAT1. Science Adv. 2020 Jul. PubMed
  • Wu M, Karadoulama E, Lloret-Llinares M, Rouviere JO, Vaagensø CS, Moravec M, Li B, Wang J, Wu G, Gockert M, Pelechano V, Jensen TH, Sandelin A. The RNA exosome shapes the expression of key protein-coding genes. Nucleic Acids Res. 2020 Sept 4. PubMed
  • Melko M, Winczura K, Rouvière JO, Oborská-Oplová M, Andersen PK, Jensen TH.  Mapping domains of ARS2 critical for its RNA decay capacity. Nucleic Acids Res. 2020 Jul 9. PubMed
  • McKellar SW, Ivanova I, van Nues RW, Cordiner RA, Worboys W, Langford A, Jensen TH, Granneman S. Monitoring Protein-RNA Interaction Dynamics in vivo at High Temporal Resolution using χCRAC. J Vis Exp. 2020 May 9. PubMed
  • Wu G, Schmid M, Rib L, Polak P, Meola N, Sandelin A, Jensen THA Two-Layered Targeting Mechanism Underlies Nuclear RNA Sorting by the Human Exosome. Cell Rep. 2020 Feb 18. PubMed
  • Silla T, Schmid M, Dou Y, Garland W, Milek M, Imami K, Johnsen D, Polak P, Andersen JS, Selbach M, Landthaler M, Jensen TH. The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay. Nucleic Acids Res. 2020 Mar 18. PubMed
  • Lloret-Llinares M, Jensen TH. Global Identification of Human Exosome Substrates Using RNA Interference and RNA Sequencing. Methods Mol Biol. 2020. PubMed.