Institut for Molekylærbiologi og Genetik

Aarhus Universitets segl

Publications

2023

  • Ross A Cordiner, Yuhui Dou, Rune Thomsen, Andrii Bugai, Sander Granneman & Torben Heick Jensen. Temporal-iCLIP captures co-transcriptional RNA-protein interactions. Nature Communications, 2023, PubMed.

2022

  • Bush JA, Meyer SM, Fuerst R, Tong Y, Li Y, Benhamou RI, Aikawa H, Zanon PRA, Gibaut QMR, Angelbello AJ, Gendron TF, Zhang YJ, Petrucelli L, Heick Jensen T, Childs-Disney JL, Disney MD. A blood-brain penetrant RNA-targeted small molecule triggers elimination of r(G4C2)exp in c9ALS/FTD via the nuclear RNA exosome. Proc Natl Acad Sci U S A., 2022, PubMed
  • Mengjun Wu, Manfred Schmid, Torben Heick Jensen & Albin Sandelin. Computational identification of signals predictive for nuclear RNA exosome degradation pathway targeting. NAR Genom Bioinform, 2022. PubMed.
  • Garland W, Müller I, Wu M, Schmid M, Imamura K, Rib L, Sandelin A, Helin K, Jensen TH. Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression. Mol Cell. 2022. PubMed.
  • Gerlach P, Garland W, Lingaraju M, Salerno-Kochan A, Bonneau F, Basquin J, Jensen TH, Conti E. Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome. Mol Cell. 2022, PubMed.
  • Rouvière JO, Lykke-Andersen S, Jensen TH. Control of non-productive RNA polymerase II transcription via its early termination in metazoans. Biochem Soc Trans., 2022, PubMed
  • Gockert M, Schmid M, Jakobsen L, Jens M, Andersen JS, Jensen TH. Rapid factor depletion highlights intricacies of nucleoplasmic RNA degradation. Nucleic Acids Res. 2022, PubMed.

2021

  • Tanu T, Taniue K, Imamura K, Onoguchi-Mizutani R, Han H, Jensen TH, Akimitsu N. hnRNPH1-MTR4 complex-mediated regulation of NEAT1v2 stability is critical for IL8 expression. RNA Biol. 2021 PubMed
  • Tudek A, Krawczyk PS, Mrocze k S, Tomecki R, Turtola M, Matylla-Kulinska K, Jensen TH, Dziembowski A. Global view on the metabolism of RNA poly(A) tails in yeast Saccharomyces cerevisiae. Nature Comm. 2021 PubMed. 

  • Turtola M, Manav CA, Kumar A, Tudek A, Krawczyk P, Mroczek S, Dziembowski A, Schmid M, Casañal A, Passmore L, Jensen TH. Three-layered control of nuclear mRNA poly(A) tail length in Saccharomyces cerevisiae. Genes and Dev. 2021 PubMed

  • Grenov A, Moss L, Edelheit S, Cordiner R, Schmiedel D, Biram A, Hanna J, Jensen TH, Schwartz S, Shulman Z. The germinal center reaction depends on RNA methylation and divergent functions of specific methyl-readers. Journal of Exp Med. 2021 PubMed

  • Lykke-Andersen S, Rouvière JO, Jensen TH. ARS2/SRRT: at the nexus of RNA polymerase II transcription, transcript maturation and quality control. Biochem Soc Trans. 2021 PubMed
  • Lykke-Andersen S, Žumer K, Molska EŠ, Rouvière JO, Wu G, Demel C, Schwalb B, Schmid M, Cramer P, Jensen TH. Integrator is a genome-wide attenuator of non-productive transcription. Mol. Cell 2021 PubMed

2020

  • Hollensen AK, Thomsen HS, Lloret-Llinares M, Kamstrup AB, Jensen JM, Luckmann M, Birkmose N, Palmfeldt J, Jensen TH, Hansen TB, Damgaard CK. circZNF827 nucleates a transcription inhibitory complex to balance neuronal differentiation. Elife 2020 Nov 11. PubMed
  • Dou Y, Barbosa I, Jiang H, Iasillo C, Molloy KR, Schulze WM, Cusack S, Schmid M, Le Hir H, LaCava J, Jensen TH. NCBP3 positively impacts mRNA biogenesis. Nucleic Acids Res. 2020 Sept 22. PubMed
  • Dou Y, Kalmykova S, Pashkova M, Oghbaie M, Jiang H, Molloy KR, Chait BT, Rout MP, Fenyö D, Jensen TH, Altukhov I, LaCava J. Affinity proteomic dissection of the human nuclear cap-binding complex interactome. Nucleic Acids Res. 2020 Sept 22. PubMed
  • Barra J, Gaidosh GS, Blumenthal E, Beckedorff F, Tayari MM, Kirstein N, Karakach TK, Jensen TH, Impens F, Gevaert K, Leucci E, Shiekhattar R, Marine JC. Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA NEAT1. Science Adv. 2020 Jul. PubMed
  • Wu M, Karadoulama E, Lloret-Llinares M, Rouviere JO, Vaagensø CS, Moravec M, Li B, Wang J, Wu G, Gockert M, Pelechano V, Jensen TH, Sandelin A. The RNA exosome shapes the expression of key protein-coding genes. Nucleic Acids Res. 2020 Sept 4. PubMed
  • Melko M, Winczura K, Rouvière JO, Oborská-Oplová M, Andersen PK, Jensen TH.  Mapping domains of ARS2 critical for its RNA decay capacity. Nucleic Acids Res. 2020 Jul 9. PubMed
  • McKellar SW, Ivanova I, van Nues RW, Cordiner RA, Worboys W, Langford A, Jensen TH, Granneman S. Monitoring Protein-RNA Interaction Dynamics in vivo at High Temporal Resolution using χCRAC. J Vis Exp. 2020 May 9. PubMed
  • Wu G, Schmid M, Rib L, Polak P, Meola N, Sandelin A, Jensen TH. A Two-Layered Targeting Mechanism Underlies Nuclear RNA Sorting by the Human Exosome. Cell Rep. 2020 Feb 18. PubMed
  • Silla T, Schmid M, Dou Y, Garland W, Milek M, Imami K, Johnsen D, Polak P, Andersen JS, Selbach M, Landthaler M, Jensen TH. The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay. Nucleic Acids Res. 2020 Mar 18. PubMed
  • Lloret-Llinares M, Jensen TH. Global Identification of Human Exosome Substrates Using RNA Interference and RNA Sequencing. Methods Mol Biol. 2020. PubMed.

2019

  • Schmid M, Jensen TH. The Nuclear RNA Exosome and Its Cofactors. Adv Exp Med Biol. 2019. PubMed
  • Garland W, Comet I, Wu M, Radzisheuskaya A, Rib L, Vitting-Seerup K, Lloret-Llinares M, Sandelin A, Helin K, Jensen TH. A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2. Cell Reports 2019 Nov 12. PubMed
  • Garland W, Jensen TH. Nuclear sorting of RNA. Wiley Interdiscip Rev RNA 2019 Nov 11. PubMed
  • Adriaens C, Rambow F, Bervoets G, Silla T, Mito M, Chiba T, Hiroshi A, Hirose T, Nakagawa S, Jensen TH, Marine JC. The lncRNA NEAT1_1 is seemingly dispensable for normal tissue homeostasis and cancer cell growth. RNA 2019 Sep 24. PubMed
  • Schmid M, Tudek A, Jensen TH. Preparation of RNA 3’ End Sequencing Libraries of Total and 4-thiouracil Labeled RNA for Simultaneous Measurement of Transcription, RNA Synthesis and Decay in S. cerevisiae. Bio Protoc. 2019 Mar 20. PubMed
  • Tudek A, Schmid M, Jensen TH. Escaping nuclear decay: the significance of mRNA export for gene expression. Curr Genet. 2019 Apr. PubMed

2018

  • Lykke-Andersen S, Ardal BK, Hollensen AK, Damgaard CK, Jensen TH. Box C/D snoRNP autoregulation by a cis-acting snoRNA in the NOP56 pre-mRNA. Molecular Cell 2018 Oct 4.

  • Lloret-Llinares M, Karadoulama E, Chen Y, Wojenski L, Villafano G, Bornhold-Lange J, Andersson R, Core L, Sandelin A, Jensen TH. The RNA exosome contributes to gene expression regulation during stem cell differentiation. Nucleic Acids Res. 2018 Sept 13 PubMed

  •  Tudek A, Lloret-Llinares M, Jensen TH. The multitasking polyA tail: Nuclear RNA maturation, degradation and export. Approved for publication in the upcoming theme issue of Philos Trans R Soc Lond B Biol Sci.
  • Schmid M, Tudek A, Jensen TH. Simultaneous Measurement of Transcriptional and Post-transcriptional Parameters by 3' End RNA-Seq. Cell Reports 2018 Aug 28 PubMed
  • Tudek A, Schmid M, Makaras M, Barrass JD, Beggs JD, Jensen TH. A Nuclear Export Block Triggers the Decay of Newly Synthesized Polyadenylated RNA. Cell Reports 2018 Aug 28 PubMed
  • Silla T, Karadoulama E, Mąkosa D, Lubas M, Jensen TH. The RNA Exosome Adaptor ZFC3H1 Functionally Competes with Nuclear Export Activity to Retain Target Transcripts. Cell Reports 2018 May 15 PubMed
  • Imamura K, Takaya A, Ishida YI, Fuuoka Y, Taya T, Nakaki R, Kakeda M, Imamachi N, Sato A, Yamada T, Onoguchi-Mizutani R, Akizuki G, Tanu T, Tao K. Miyao S, Suzuki Y, Nagahama M, Yamamoto T, Jensen TH, Akimitsu N. Diminished nuclear RNA decay upon Salmonella infection upregulates antibacterial noncoding RNAs. EMBO J. 2018 Jul 2 PubMed
  • Rennie S, Dalby M, Lloret-Llinares M, Bakoulis S, Dalager CV, Jensen TH, Andersson R. Transcription start site analysis reveals widespread divergent transcription in D. melanogaster and core promoter-encoded enhancer activities. Nucleic Acids Res. 2018 Apr 6 PubMed
  • Winczura K, Schmid M, Iasillo C, Molloy KR, Harder LM, Andersen JS, LaCava J, Jensen TH. Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions. Cell Reports 2018 Jan 2 PubMed

2017

  • Iasillo C, Schmid M, Yahia Y, Maqbool MA, Descostes N, Karadoulama E, Bertrand E, Andrau JC, Jensen TH. ARS2 is a general suppressor of pervasive transcription. Nucleic Acids Res. 2017 July 24 PubMed
  • Zhang M, Lykke-Andersen S, Zhu B, Xiao W, Hoskins JW, Zhang X, Rost LM, Collins I, Bunt MV, Jia J, Parikh H, Zhang T, Song L, Jermusyk A, Chung CC, Zhu B, Zhou W, Matters GL, Kurtz RC, Yeager M, Jensen TH, Brown KM, Ongen H, Bamlet WR, Murray BA, McCarthy MI, Chanock SJ, Chatterjee N, Wolpin BM, Smith JP, Olson SH, Petersen GM, Shi J, Amundadottir L. Characterising cis-regulatory variation in the transcriptome of histologically normal and tumour-derived pancreatic tissues. Gut 2017 Jun 20 PubMed
  • Kofoed RH, Zheng J, Ferreira N, Lykke-Andersen S, Salvi M, Betzer C, Reimer L, Jensen TH, Fog K, Jensen PH. Polo-like kinase 2 modulates α-synuclein protein levels by regulating its mRNA production. Neurobiol Dis. 2017 Jun 23 PubMed
  • Meola N, Jensen TH. Targeting the nuclear RNA exosome: Poly(A) binding proteins enter the stage. RNA Biol. 2017 Apr 19 PubMed
  • Krogh N, Pietschmann M, Schmid M, Jensen TH, Nielsen H. Lariat capping as a tool to manipulate the 5' end of individual yeast mRNA species in vivo. RNA. 2017 Feb 3 PubMed
  • Giacometti S, Benbahouche NE, Domanski M, Robert MC, Meola N, Lubas M, Bukenborg J, Andersen JS, Schulze WM, Verheggen C, Kudla G, Jensen TH, Bertrand E. Mutually Exclusive CBC-Containing Complexes Contribute to RNA Fate. Cell Reports 2017 Mar 14 PubMed
  • Tudek A, Schmid M, Jensen TH. Nuclear Decay Factors Crack Up mRNA. Mol Cell. 2017 Mar 2 PubMed

2016

  • Falk S, Finogenova K, Melko M, Benda C, Lykke-Andersen S, Jensen TH, Conti E. Structure of the RBM7-ZCCHC8 core of the NEXT complex reveals connections to splicing factors. Nat Commun. 2016 Dec 1. PubMed
  • Meola M, Domanski M, Karadoulama E, Chen Y, Gentil C, Pultz D, Vitting-Seerup K, Lykke-Andersen S, Andersen JS, Sandelin A and Jensen TH. Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts. Mol Cell. 2016 Oct 26. PubMed
  • Molleston JM, Sabin LR, Moy RH, Menghani SV, Rausch K, Gordesky-Gold B, Hopkins KC, Zhou R, Jensen TH, Wilusz JE, and Cherry S. A conserved virus-induced cytoplasmic TRAMP-like complex recruits the exosome to target viral RNA for degradation. Genes Dev. 2016 Jul 15;30(14):1658-70. PubMed
  • Chen Y, Pai AA, Herudek J, Lubas M, Meola N, Järvelin AI, Andersson R, Pelechano V, Steinmetz LM, Jensen TH, Sandelin A. Principles for RNA metabolism and alternative transcription initiation within closely spaced promoters. Nat Genet. 2016 Jul 25. PubMed
  • Domanski M, Upla P, Rice WJ, Molloy KR, Ketaren NE, Stokes DL, Jensen TH, Rout MP, LaCava. Purification and analysis of endogenous human RNA exosome complexes. RNA. 2016 Jul 11. Open Access.
  • Lloret-Llinares M, Mapendano CK, Martlev LH, Lykke-Andersen S, Jensen TH. Relationships between PROMPT and gene expression. RNA Biol. 2016 PubMed

2015

  • Andersson R, Chen Y, Core L, Lis JT, Sandelin A, Jensen TH. Human Gene Promoters Are Intrinsically Bidirectional. Mol Cell. 2015 Nov 5;60(3):346-7. PubMed
  • Lykke-Andersen S, Jensen TH. Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes. Nat Rev Mol Cell Biol. 2015 Sep 23. PubMed
  • Schmid M, Olszewski P, Pelechano V, Gupta I, Steinmetz LM, Jensen TH. The Nuclear PolyA-Binding Protein Nab2p Is Essential for mRNA Production. Cell Reports. 2015 Jun 24. Open Access. PubMed
  • Hakhverdyan Z, Domanski M, Hough LE, Oroskar AA, Oroskar AR, Keegan S, Dilworth DJ, Molloy KR, Sherman V, Aitchison JD, Fenyö D, Chait BT, Jensen TH, Rout MP, LaCava J. Rapid, optimized interactomic screening. Nature Methods. 2015 Jun;12(6):553-60. PubMed
  • Lubas M, Andersen PR, Schein A, Dziembowski A, Kudla G, Jensen TH. The human nuclear exosome targeting complex is loaded onto newly synthesized RNA to direct early ribonucleolysis. Cell Reports. 2015 Jan 13;10(2):178-92. Open Access. PubMed

2014

  • Lykke-Andersen S, Chen Y, Ardal BR, Lilje B, Waage J, Sandelin A, Jensen TH. Human nonsense-mediated RNA decay initiates widely by endonucleolysis and targets snoRNA host genes. Genes Dev. 2014 Nov 15;28(22):2498-517. PubMed
  • Andersson R, Refsing Andersen P, Valen E, Core LJ, Bornholdt J, Boyd M, Heick Jensen T, Sandelin A. Nuclear stability and transcriptional directionality separate functionally distinct RNA species. Nat Commun. 2014 Nov 12;5:5336. PubMed
  • Schmid M, Jensen TH. SnapShot: nuclear RNAPII transcript modification. Cell. 2014 May 22;157(5):1244. PubMed
  • Andersson R, Gebhard C, Miguel-Escalada I, Hoof I, Bornholdt J, Boyd M, Chen Y, Zhao X, Schmidl C, Suzuki T, Ntini E, Arner E, Valen E, Li K, Schwarzfischer L, Glatz D, Raithel J, Lilje B, Rapin N, Bagger FO, Jørgensen M, Andersen PR, Bertin N, Rackham O, Burroughs AM, Baillie JK, Ishizu Y, Shimizu Y, Furuhata E, Maeda S, Negishi Y, Mungall CJ, Meehan TF, Lassmann T, Itoh M, Kawaji H, Kondo N, Kawai J, Lennartsson A, Daub CO, Heutink P, Hume DA, Jensen TH, Suzuki H, Hayashizaki Y, Müller F; FANTOM Consortium, Forrest AR, Carninci P, Rehli M, Sandelin A. An atlas of active enhancers across human cell types and tissues. Nature. 2014 Mar 27; 507(7493): 455-61. PubMed
  • Jimeno-González S, Schmid M, Malagon F, Haaning LL, Jensen TH. Rat1p maintains RNA polymerase II CTD phosphorylation balance. RNA. 2014 Apr;20(4):551-8. PubMed

2013

  • Andersen PR, Domanski M, Kristiansen MS, Storvall H, Ntini E, Verheggen C, Schein A, Bunkenborg J, Poser I, Hallais M, Sandberg R, Hyman A, Lacava J, Rout MP, Andersen JS, Bertrand E, Jensen TH. The human cap-binding complex is functionally connected to the nuclear RNA exosome. Nat Struct Mol Biol. 2013 Nov 24. PubMed
  • Hallais M, Pontvianne F, Andersen PR, Clerici M, Lener D, Benbahouche NE, Gostan T, Vandermoere F, Robert MC, Cusack S, Verheggen C, Jensen TH, Bertrand E. CBC-ARS2 stimulates 3'-end maturation of multiple RNA families and favors cap-proximal processing. Nat Struct Mol Biol. 2013 Nov 24. PubMed
  • Jensen TH, Jacquier A, Libri D. Dealing with pervasive transcription. Mol Cell. 2013 Nov 21. PubMed
  • Saguez C, Gonzales FA, Schmid M, Bøggild A, Latrick CM, Malagon F, Putnam A, Sanderson L, Jankowsky E, Brodersen DE, Jensen TH. Mutational analysis of the yeast RNA helicase Sub2p reveals conserved domains required for growth, mRNA export, and genomic stability. RNA. 2013 Oct 19. PubMed
  • Ntini E, Järvelin AI, Bornholdt J, Chen Y, Boyd M, Jørgensen M, Andersson R, Hoof I, Schein A, Andersen PR, Andersen PK, Preker P, Valen E, Zhao X, Pelechano V, Steinmetz LM, Sandelin A, Jensen TH. Polyadenylation site-induced decay of upstream transcripts enforces promoter directionality. Nat Struct Mol Biol. 2013 Jul 14. PubMed
  • Lubas M, Damgaard CK, Tomecki R, Cysewski D, Jensen TH, Dziembowski A. Exonuclease hDIS3L2 specifies an exosome-independent 3'-5' degradation pathway of human cytoplasmic mRNA. EMBO J. 2013 Jul 3 PubMed
  • Andersen PK, Jensen TH, Lykke-Andersen S. Making ends meet: coordination between RNA 3'-end processing and transcription initiation. Wiley Interdiscip Rev RNA. 2013 May-Jun;4(3):233-46. PubMed
  • Chlebowski A, Lubas M, Jensen TH, Dziembowski A. RNA decay machines: the exosome. Biochim Biophys Acta. 2013 Jun-Jul;1829(6-7):552-60. PubMed

2012

  • Andersen PK, Lykke-Andersen S, Jensen TH. Promoter proximal polyadenylation sites reduce transcription activity. Genes and Development (2012) PubMed
  • Schmid M, Jensen TH. Transcription-associated quality control of mRNP. Biochim Biophys Acta. 2012 Sep 6. PubMed
  • Kallehauge TB, Robert M-C, Bertrand E, Jensen TH. Nuclear retention prevents premature cytoplasmic appearance of mRNA. Molecular Cell (2012) Aug 22. PubMed
  • Lubas M, Chlebowski A, Dziembowski A, Jensen TH. Biochemistry and Function of the RNA Exosomes. The Enzymes vol 31 (2012). In press.
  • Schmid M, Poulsen MB, Olszewski P, Pelechano V, Saguez C, Gupta I, Steinmetz LM, Moore C, Jensen TH. Rrp6p controls mRNA poly(a) tail length and its decoration with poly(a) binding proteins. Molecular Cell 2012 Jul 27;47(2):267-80. Epub 2012 Jun 7. PubMed
  • Domanski M, Molloy K, Jiang H, Chait BT, Rout MP, Jensen TH, Lacava J. Improved methodology for the affinity isolation of human protein complexes expressed at near endogenous levels. Biotechniques 2012 May;0(0):1-6. PubMed
  • Mühlemann O, Jensen TH. mRNP quality control goes regulatory. Trends Genetics 2012 Feb;28(2):70-7. Epub 2011 Dec 9. PubMed
  • Feddersen A, Dedic E, Poulsen EG, Schmid M, Van LB, Jensen TH, Brodersen DE. Saccharomyces cerevisiae Ngl3p is an active 3'-5' exonuclease with a specificity towards poly-A RNA reminiscent of cellular deadenylases. Nucleic Acids Research 2012 Jan;40(2):837-46. Epub 2011 Sep 29. PubMed

2011

  • Preker P, Almvig K, Christensen MS, Valen E, Mapendano CK, Sandelin A, Jensen TH. PROMoter uPstream Transcripts share characteristics with mRNAs and are produced upstream of all three major types of mammalian promoters. Nucleic Acids Research 2011 Sep 1;39(16):7179-93. PubMed
  • Assenholt J, Mouaikel J, Saguez C, Rougemaille M, Libri D, Jensen TH. Implication of Ccr4-Not complex function in mRNA quality control in Saccharomyces cerevisiae. RNA 2011 Aug 23. PubMed
  • Lubas M, Christensen MS, Kristiansen MS, Domanski M, Falkenby LG, Lykke-Andersen S, Andersen JS, Dziembowski A, Jensen TH. Interaction profiling identifies the human nuclear exosome targeting complex. Mol Cell. 2011 Aug 19;43(4):624-37. PubMed
  • Valen E, Preker P, Andersen PR, Zhao X, Chen Y, Ender C, Dueck A, Meister G, Sandelin A, Jensen TH. Biogenic mechanisms and utilization of small RNAs derived from human protein-coding genes. Nat Struct Mol Biol. 2011 Aug 7;18(9):1075-82. PubMed
  • Lykke-Andersen S, Mapendano C & Jensen TH 2011. An ending is a new beginning: Transcription termination supports re-initiation. Cell Cycle 10(6). Epub 15 March.
  • Lykke-Andersen S, Tomecki R, Jensen TH & Dziembowski A 2011. The eukaryotic RNA exosome: Same scaffold but variable catalytic subunits. RNA Biology 8(1):61-66. PubMed
  • Malagon F & Jensen TH 2011. T-body formation precedes virus-like particle maturation in S. cerevisiae. RNA Biology 8(2). Epub 1 March.

2010

  • Andersen PK & Jensen TH 2010. A Pause to Splice. Molecular Cell 40(4): 503-505. PubMed
  • Jensen TH 2010 (ed). RNA Exosome. New York / Austin: Springer Science+Business Media / Landes Bioscience. (book)
  • Jimeno-González S, Haaning LL, Malagon F & Jensen TH 2010. The Yeast 5′-3′ Exonuclease Rat1p Functions during Transcription Elongation by RNA Polymerase II. Molecular Cell 37(4):580-587. PubMed
  • Mapendano CK, Lykke-Andersen S, Kjems J, Bertrand E & Jensen TH 2010. Crosstalk between mRNA 3' end processing and transcription initiation. Molecular Cell 40:310-322. PubMed
  • Preker P & Jensen TH 2010. Translation by Remote Control. Cell 143(4): 552-563. OpenAccess
  • Schmid M & Jensen TH 2010. Nuclear quality control of RNA polymerase II transcripts. Wiley Interdisciplinary Reviews: RNA 1(3):474-485.
  • Tomecki R, Kristiansen MS, Lykke-Andersen S, Chlebowski A, Larsen KM, Szczesny RJ, Drazkowska K, Pastula A, Andersen JS, Stepien PP, Dziembowski A & Jensen TH 2010. The human core exosome binds to differentially localized processive ribonucleases: hDIS3 and hDIS3L. EMBO Journal 29:2342-2357. PubMed

2009

  • Eberle AB, Lykke-Andersen S, Mühlemann O & Jensen TH 2009. SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells. Nature Structural & Molecular Biology 16:49-55. Published online 7 December 2008. PubMed
  • Lykke-Andersen S, Brodersen DE & Jensen TH 2009. Origins and activities of the eukaryotic exosome. Journal of Cell Science 122:1487-1494. PubMed
  • Preker P, Nielsen J, Schierup MH & Jensen TH 2009. RNA polymerase plays both sides: Vivid and bidirectional transcription around and upstream of active promoters. Cell Cycle 8(8):1106-1107. Published online 26 April. PubMed
  • Qu X, Lykke-Andersen S, Nasser T, Saguez C, Bertrand E, Jensen TH & Moore C 2009. Assembly of an export-competent mRNP is needed for efficient release of the 3' end processing complex after polyadenylation. Molecular and Cellular Biology 29(19):5327-5338. Published online 27 July. PubMed
  • Saguez C & Jensen TH 2009. Assembly of Export-Competent mRNP: It's All about Being Connected. Molecular Cell 33(2):139-140. PubMed

2008

  • Andersen KR, Jensen TH & Brodersen DE 2008. Take the “A” tail – quality control of ribosomal and transfer RNA. Biochimica et Biophysica Acta 1779:532-537. PubMed
  • Assenholt J, Mouaikel J, Andersen KR, Brodersen DE, Libri D & Jensen TH 2008. Exonucleolysis is required for nuclear mRNA quality control in yeast THO mutants. RNA 14:2305-2313. PubMed
  • Damgaard CK, Kahns S, Lykke-Andersen S, Nielsen AL, Jensen TH & Kjems J 2008. A 5' splice site enhances the recruitment of basal transcription initiation factors in vivo. Molecular Cell 29:271-278. PubMed
  • Jensen MM, Christensen MS, Bonven B & Jensen TH 2008. Requirements for chromatin reassembly during transcriptional downregulation of a heat shock gene in Saccharomyces cerevisiae. FEBS Journal 275:2956-2964. PubMed
  • Kammler S, Lykke-Andersen S & Jensen TH 2008. The RNA exosome component hRrp6 is a target for 5-fluorouracil in human cells. Molecular Cancer Research 6:990-995. PubMed
  • Malagon F & Jensen TH 2008. The T-body: a new cytoplasmic RNA granule in Saccharomyces cerevisiae. Molecular and Cellular Biology 28:6022-6032. PubMed
  • Preker P, Nielsen J, Kammler S, Lykke-Andersen S, Christensen MS, Mapendano CK, Schierup MH & Jensen TH 2008. RNA Exosome Depletion Reveals Transcription Upstream of Active Human Promoters. Science 322:1851-1854. PubMed
  • Rougemaille M, Dieppois G, Kisseleva-Romanova E, Gudipati RK, Lemoine S, Blugeon C, Boulay J, Jensen TH, Stutz F, Devaux F &  Libri D 2008. THO/Sub2p functions to coordinate 3'-end processing with gene-nuclear pore association. Cell 135:308-321. PubMed
  • Saguez C, Schmid M, Olesen JR, El-Hady Ghazy MA, Qu X, Poulsen MB, Nasser T, Moore C & Jensen TH. Nuclear mRNA Surveillance in THO/sub2 Mutants Is Triggered by Inefficient Polyadenylation. Molecular Cell 31:91-103. PubMed
  • Schmid M & Jensen TH 2008. Quality control of mRNP in the nucleus. Chromosoma 117(5):419-429. PubMed
  • Schmid M & Jensen TH 2008. The exosome: A multipurpose RNA decay machine. Trends in Biochemical Sciences 33:501-510. PubMed
  • Schmid M, Rougemaille M, Libri D & Jensen TH: Estimating nuclear mRNA decay in Saccharomyces cerevisiae. Methods in Enzymolog 449:205-219. PubMed
  • Thomsen R, Saguez C, Nasser T & Jensen TH 2008. General, rapid, and transcription-dependent fragmentation of nucleolar antigens in S. cerevisiae mRNA export mutants. RNA 14:706-716. PubMed

2007

  • Abruzzi K, Denome S, Olesen JR, Haaning LL, Assenholt J, Jensen TH & Rosbash M 2007. A novel plasmid-based microarray screen identifies suppressors of rrp6 in Saccharomyces cerevisiae. Molecular and Cellular Biology 27:1044-1055.
  • Blechingberg J, Lykke-Andersen S, Jensen TH, Jørgensen AL & Nielsen AL 2007. Regulatory Mechanisms for 3'-end Alternative Splicing and Polyadenylation of the Glial Fibrillary Acidic Protein, GFAP, Transcript.  Nucleic Acids Research 35:7636-7650.
  • Lykke-Andersen S & Jensen TH 2007. Overlapping pathways dictate termination of RNA polymerase II transcription. Biochemie 89:1177-1182.
  • Lykke-Andersen S, Piñol-Roma S & Kjems J 2007. The human ADAR1 transcripts contain an alternative retained intron within a region that functions both as a 5’UTR and an ORF. RNA 13:1732-1744.
  • Rougemaille M, Olesen JR, Thomsen R, Seraphin B, Libri D & Jensen TH 2007. Dissecting mechanisms of mRNA surveillance in THO/sub2 complex mutants. EMBO Journal 26:2317-2326.

2006

  • Lykke-Andersen S &  Jensen TH 2006. CUT it out - silencing of noise in the transcriptome. Nature Structural & Molecular Biology 13:860-861.
  • Midtgaard SF, Assenholt J, Jonstrup AT, Van LB, Jensen TH & Brodersen DE 2006. Structure of the nuclear exosome component Rrp6p reveals an interplay between the active site and the HRDC domain. Proceedings of the National Academy of Sciences USA 103:11898-11903.
  • Zhelkovsky A, Tacahashi Y, Nasser T, He X, Sterzer U, Jensen TH, Domdey H & Moore C 2006. The role of the Brr5/Ysh1 C-terminal domain and its homolog Syc1 in mRNA 3´-end processing in Saccharomyces cerevisiae. RNA 12:435-445.

2005

  • Jensen TH & Moore C 2005. Reviving the Exosome. Cell 121:660-662.
  • Olesen JR, Libri D& Jensen TH 2005. A link between transcription and mRNP quality in Saccharomyces cerevisiae. RNA Biology 1:149-152.
  • Saguez C, Olesen JR & Jensen TH 2005. Formation of Export Competent mRNP: Escaping Nuclear Destruction. Current Opinion in Cell Biology 17:287-293.
  • Thomsen R, Nielsen PS & Jensen TH 2005. Dramatically improved RNA in situ hybridization signals using LNA-modified probes. RNA 11:1745-1748.
Revideret 08.03.2023
-
Manfred Schmid