2025

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Gabs, E., Aalto-Setälä, E., Välisaari, A., Malinen, A. M., Jensen, T. H., McLaughlin, S. H., Passmore, L. A. & Turtola, M. (2025). A kinetic ruler controls mRNA poly(A) tail length. Genes & Development, 39(21-22), 1377-1394. https://doi.org/10.1101/gad.352912.125

Garland, W. & Jensen, T. H. (2025). Integrator: A guardian against RNA-induced chaos. Cell Chemical Biology, 32(6), 780-782. https://doi.org/10.1016/j.chembiol.2025.05.009

Dubiez, E., Garland, W., Finderup Brask, M., Boeri Erba, E., Heick Jensen, T., Kadlec, J. & Cusack, S. (2025). Structural basis for the synergistic assembly of the snRNA export complex. Nature Structural and Molecular Biology, 32(8), 1555-1566. https://doi.org/10.1038/s41594-025-01595-5

Auxillos, J., Stigliani, A., Vaagensø, C. S., Garland, W., Niazi, A. M., Valen, E., Jensen, T. H. & Sandelin, A. (2025). True length of diverse capped RNA sequencing (TLDR-seq): 5'-3'-end sequencing of capped RNAs regardless of 3'-end status. Nucleic Acids Research, 53(6), Artikel gkaf240. https://doi.org/10.1093/nar/gkaf240

2024

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Imamura, K., Garland, W., Schmid, M., Jakobsen, L., Sato, K., Rouvière, J. O., Jakobsen, K. P., Burlacu, E., Lopez, M. L., Lykke-Andersen, S., Andersen, J. S. & Jensen, T. H. (2024). A functional connection between the Microprocessor and a variant NEXT complex. Molecular Cell, 84(21), 4158-4174.e6. https://doi.org/10.1016/j.molcel.2024.10.015

Garland, W., Rouvière, J. O. & Heick Jensen, T. (2024). Assigning function to an unexplored Integrator module. Molecular Cell, 84(13), 2405-2406. https://doi.org/10.1016/j.molcel.2024.06.014

Davidson, L., Rouvière, J. O., Sousa-Luís, R., Nojima, T., Proudfoot, N. J., Jensen, T. H. & West, S. (2024). DNA-directed termination of mammalian RNA polymerase II. Genes and Development, 38(21-24), 998-1019. https://doi.org/10.1101/gad.351978.124

Czarnocka-Cieciura, A., Poznański, J., Turtola, M., Tomecki, R., Krawczyk, P. S., Mroczek, S., Orzeł, W., Saha, U., Jensen, T. H., Dziembowski, A. & Tudek, A. (2024). Modeling of mRNA deadenylation rates reveal a complex relationship between mRNA deadenylation and decay. EMBO Journal, 43(24), 6525-6554. Artikel e1737. https://doi.org/10.1038/s44318-024-00258-3

Garland, W. & Jensen, T. H. (2024). Nuclear sorting of short RNA polymerase II transcripts. Molecular Cell, 84(19), 3644-3655. https://doi.org/10.1016/j.molcel.2024.08.024

Lykke-Andersen, S., Rouvière, J. O., Schmid, M., Gockert, M. & Jensen, T. H. (2024). Protocol for generating customizable and reproducible plots of sequencing coverage data using the seqNdisplayR package. STAR Protocols, 5(2), Artikel 102960. https://doi.org/10.1016/j.xpro.2024.102960

Wu, G., Rouvière, J. O., Schmid, M. & Heick Jensen, T. (2024). RNA 3′end tailing safeguards cells against products of pervasive transcription termination. Nature Communications, 15(1), Artikel 10446. https://doi.org/10.1038/s41467-024-54834-6

Dubiez, E., Pellegrini, E., Finderup Brask, M., Garland, W., Foucher, A. E., Huard, K., Heick Jensen, T., Cusack, S. & Kadlec, J. (2024). Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex. Cell Reports, 43(1), Artikel 113639. https://doi.org/10.1016/j.celrep.2023.113639

Kruse, T., Garvanska, D. H., Varga, J. K., Garland, W., McEwan, B. C., Hein, J. B., Weisser, M. B., Benavides-Puy, I., Chan, C. B., Sotelo-Parrilla, P., Mendez, B. L., Jeyaprakash, A. A., Schueler-Furman, O., Jensen, T. H., Kettenbach, A. N. & Nilsson, J. (2024). Substrate recognition principles for the PP2A-B55 protein phosphatase. Science Advances, 10(40), eadp5491. Artikel eadp5491. https://doi.org/10.1126/sciadv.adp5491

2023

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Rouvière, J. O., Salerno-Kochan, A., Lykke-Andersen, S., Garland, W., Dou, Y., Rathore, O., Molska, E. Š., Wu, G., Schmid, M., Bugai, A., Jakobsen, L., Žumer, K., Cramer, P., Andersen, J. S., Conti, E. & Jensen, T. H. (2023). ARS2 instructs early transcription termination-coupled RNA decay by recruiting ZC3H4 to nascent transcripts. Molecular Cell, 83(13), 2240-2257. https://doi.org/10.1016/j.molcel.2023.05.028

Polák, P., Garland, W., Rathore, O., Schmid, M., Salerno-Kochan, A., Jakobsen, L., Gockert, M., Gerlach, P., Silla, T., Andersen, J. S., Conti, E. & Jensen, T. H. (2023). Dual agonistic and antagonistic roles of ZC3H18 provide for co-activation of distinct nuclear RNA decay pathways. Cell Reports, 42(11), Artikel 113325. https://doi.org/10.1016/j.celrep.2023.113325

Cordiner, R. A., Dou, Y., Thomsen, R., Bugai, A., Granneman, S. & Heick Jensen, T. (2023). Temporal-iCLIP captures co-transcriptional RNA-protein interactions. Nature Communications, 14(1), Artikel 696. https://doi.org/10.1038/s41467-023-36345-y

2022

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Bush, J. A., Meyer, S. M., Fuerst, R., Tong, Y., Li, Y., Benhamou, R. I., Aikawa, H., Zanon, P. R. A., Gibaut, Q. M. R., Angelbello, A. J., Gendron, T. F., Zhang, Y. J., Petrucelli, L., Heick Jensen, T., Childs-Disney, J. L. & Disney, M. D. (2022). A blood-brain penetrant RNA-targeted small molecule triggers elimination of r(G₄C₂)^exp in c9ALS/FTD via the nuclear RNA exosome. Proceedings of the National Academy of Sciences (PNAS), 119(48), Artikel e2210532119. https://doi.org/10.1073/pnas.2210532119

Garland, W., Müller, I., Wu, M., Schmid, M., Imamura, K., Rib, L., Sandelin, A., Helin, K. & Jensen, T. H. (2022). Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression. Molecular Cell, 82(9), 1691-1707.e8. https://doi.org/10.1016/j.molcel.2022.03.004

Rouvière, J. O., Lykke-Andersen, S. & Jensen, T. H. (2022). Control of non-productive RNA polymerase II transcription via its early termination in metazoans. Biochemical Society Transactions, 50(1), 283-295. https://doi.org/10.1042/BST20201140

Gockert, M., Schmid, M., Jakobsen, L., Jens, M., Andersen, J. S. & Jensen, T. H. (2022). Rapid factor depletion highlights intricacies of nucleoplasmic RNA degradation. Nucleic Acids Research, 50(3), 1583-1600. https://doi.org/10.1093/nar/gkac001

Gerlach, P., Garland, W., Lingaraju, M., Salerno-Kochan, A., Bonneau, F., Basquin, J., Jensen, T. H. & Conti, E. (2022). Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome. Molecular Cell, 82(13), 2505-2518.e7. https://doi.org/10.1016/j.molcel.2022.04.011

2021

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Lykke-Andersen, S., Rouvière, J. O. & Jensen, T. H. (2021). ARS2/SRRT: At the nexus of RNA polymerase II transcription, transcript maturation and quality control. Biochemical Society Transactions, 49(3), 1325-1336. https://doi.org/10.1042/BST20201008

Tudek, A., Krawczyk, P. S., Mroczek, S., Tomecki, R., Turtola, M., Matylla-Kulińska, K., Jensen, T. H. & Dziembowski, A. (2021). Global view on the metabolism of RNA poly(A) tails in yeast Saccharomyces cerevisiae. Nature Communications, 12, Artikel 4951. https://doi.org/10.1038/s41467-021-25251-w

Tanu, T., Taniue, K., Imamura, K., Onoguchi-Mizutani, R., Han, H., Jensen, T. H. & Akimitsu, N. (2021). hnRNPH1-MTR4 complex-mediated regulation of NEAT1v2 stability is critical for IL8 expression. RNA Biology, 18(sup1), 537-547. https://doi.org/10.1080/15476286.2021.1971439

Lykke-Andersen, S., Žumer, K., Molska, E. Š., Rouvière, J. O., Wu, G., Demel, C., Schwalb, B., Schmid, M., Cramer, P. & Jensen, T. H. (2021). Integrator is a genome-wide attenuator of non-productive transcription. Molecular Cell, 81(3), 514-529.e6. https://doi.org/10.1016/j.molcel.2020.12.014

Grenov, A. C., Moss, L., Edelheit, S., Cordiner, R., Schmiedel, D., Biram, A., Hanna, J. H., Jensen, T. H., Schwartz, S. & Shulman, Z. (2021). The germinal center reaction depends on RNA methylation and divergent functions of specific methyl readers. The Journal of Experimental Medicine, 218(10), Artikel e20210360. https://doi.org/10.1084/jem.20210360

Turtola, M., Manav, C. M., Kumar, A., Tudek, A., Mroczek, S., Krawczyk, P. S., Dziembowski, A., Schmid, M., Passmore, L. A., Casanal, A. & Jensen, T. H. (2021). Three-layered control of mRNA poly(A) tail synthesis in Saccharomyces cerevisiae. Genes and Development, 35(17-18), 1290-1303. https://doi.org/10.1101/GAD.348634.121

2020

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Dou, Y., Kalmykova, S., Pashkova, M., Oghbaie, M., Jiang, H., Molloy, K. R., Chait, B. T., Rout, M. P., Fenyö, D., Jensen, T. H., Altukhov, I. & LaCava, J. (2020). Affinity proteomic dissection of the human nuclear cap-binding complex interactome. Nucleic Acids Research, 48(18), 10456-10469. https://doi.org/10.1093/nar/gkaa743

Wu, G., Schmid, M., Rib, L., Polak, P., Meola, N., Sandelin, A. & Jensen, T. H. (2020). A Two-Layered Targeting Mechanism Underlies Nuclear RNA Sorting by the Human Exosome. Cell Reports, 30(7), 2387-2401. https://doi.org/10.1016/j.celrep.2020.01.068

Hollensen, A. K., Thomsen, H. S., Lloret-Llinares, M., Kamstrup, A. B., Jensen, J. M., Luckmann, M., Birkmose, N., Palmfeldt, J., Jensen, T. H., Hansen, T. B. & Damgaard, C. K. (2020). circZNF827 nucleates a transcription inhibitory complex to balance neuronal differentiation. eLife, 9, 1-29. Artikel e58478. https://doi.org/10.7554/eLife.58478

Lloret-Llinares, M. & Jensen, T. H. (2020). Global Identification of Human Exosome Substrates Using RNA Interference and RNA Sequencing. I The Eukaryotic RNA Exosome: Methods and Protocols (s. 127-145). Humana Press. https://doi.org/10.1007/978-1-4939-9822-7_7

Barra, J., Gaidos, G. S., Blumenthal, E., Beckedorff, F., Tayar, M. M., Kirstein, N., Karakac, T. K., Jensen, T. H., Impens, F., Gevaert, K., Leucci, E., Shiekhattar, R. & Marine, J. C. (2020). Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA NEAT1. Science Advances, 6(27), Artikel eaaz9072. https://doi.org/10.1126/sciadv.aaz9072

Melko, M., Winczura, K., Rouvière, J. O., Oborská-Oplová, M., Andersen, P. K. & Heick Jensen, T. (2020). Mapping domains of ARS2 critical for its RNA decay capacity. Nucleic Acids Research, 48(12), 6943-6953. https://doi.org/10.1093/nar/gkaa445

McKellar, S. W., Ivanova, I., van Nues, R. W., Cordiner, R. A., Worboys, W., Langford, A., Jensen, T. H. & Granneman, S. (2020). Monitoring protein-RNA interaction dynamics in vivo at high temporal resolution using χCRAC. Journal of Visualized Experiments, 2020(159), Artikel e61027. https://doi.org/10.3791/61027

Dou, Y., Barbosa, I., Jiang, H., Iasillo, C., Molloy, K. R., Schulze, W. M., Cusack, S., Schmid, M., Le Hir, H., LaCava, J. & Jensen, T. H. (2020). NCBP3 positively impacts mRNA biogenesis. Nucleic Acids Research, 48(18), 10413-10427. https://doi.org/10.1093/nar/gkaa744

Garland, W. & Jensen, T. H. (2020). Nuclear sorting of RNA. Wiley Interdisciplinary Reviews: RNA, 11(2), Artikel e1572. https://doi.org/10.1002/wrna.1572

Silla, T., Schmid, M., Dou, Y., Garland, W., Milek, M., Imami, K., Johnsen, D., Polák, P., Andersen, J. S., Selbach, M., Landthaler, M. & Jensen, T. H. (2020). The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay. Nucleic Acids Research, 48(5), 2518-2530. https://doi.org/10.1093/nar/gkz1238

Wu, M., Karadoulama, E., Lloret-Llinares, M., Rouviere, J. O., Vaagensø, C. S., Moravec, M., Li, B., Wang, J., Wu, G., Gockert, M., Pelechano, V., Jensen, T. H. & Sandelin, A. (2020). The RNA exosome shapes the expression of key protein-coding genes. Nucleic Acids Research, 48(15), 8509-8528. https://doi.org/10.1093/nar/gkaa594

2019

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Garland, W., Comet, I., Wu, M., Radzisheuskaya, A., Rib, L., Vitting-Seerup, K., Lloret-Llinares, M., Sandelin, A., Helin, K. & Jensen, T. H. (2019). A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2. Cell Reports, 29(7), 1800-1811.e6. https://doi.org/10.1016/j.celrep.2019.10.011

Tudek, A., Schmid, M. & Jensen, T. H. (2019). Escaping nuclear decay: the significance of mRNA export for gene expression. Current Genetics, 65(2), 473-476. https://doi.org/10.1007/s00294-018-0913-x

Schmid, M., Tudek, A. & Jensen, T. H. (2019). Preparation of RNA 3' End Sequencing Libraries of Total and 4-thiouracil Labeled RNA for Simultaneous Measurement of Transcription, RNA Synthesis and Decay in S. cerevisiae. Bio-protocol, 9(6). https://doi.org/10.21769/BioProtoc.3189

Adriaens, C., Rambow, F., Bervoets, G., Silla, T., Mito, M., Chiba, T., Asahara, H., Hirose, T., Nakagawa, S., Jensen, T. H. & Marine, J. C. (2019). The long noncoding RNA NEAT1_1 is seemingly dispensable for normal tissue homeostasis and cancer cell growth. RNA (New York, N.Y.), 25(12), 1681-1695. https://doi.org/10.1261/rna.071456.119

Lingaraju, M., Johnsen, D., Schlundt, A., Langer, L. M., Basquin, J., Sattler, M., Heick Jensen, T., Falk, S. & Conti, E. (2019). The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs. Nature Communications, 10(1), Artikel 3393. https://doi.org/10.1038/s41467-019-11339-x

Schmid, M. & Jensen, T. H. (2019). The Nuclear RNA Exosome and Its Cofactors. I M. Oeffinger & D. Zenklusen (red.), Advances in Experimental Medicine and Biology (s. 113-132). Springer. https://doi.org/10.1007/978-3-030-31434-7_4

2018

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Tudek, A., Schmid, M., Makaras, M., Barrass, J. D., Beggs, J. D. & Jensen, T. H. (2018). A Nuclear Export Block Triggers the Decay of Newly Synthesized Polyadenylated RNA. Cell Reports, 24(9), 2457-2467.e7. https://doi.org/10.1016/j.celrep.2018.07.103

Lykke-Andersen, S., Ardal, B. K., Hollensen, A. K., Damgaard, C. K. & Jensen, T. H. (2018). Box C/D snoRNP Autoregulation by a cis-Acting snoRNA in the NOP56 Pre-mRNA. Molecular Cell, 72(1), 99-111.e1-e5. https://doi.org/10.1016/j.molcel.2018.08.017

Zhang, M., Lykke-Andersen, S., Zhu, B., Xiao, W., Hoskins, J. W., Zhang, X., Rost, L. M., Collins, I., Bunt, M. V. D., Jia, J., Parikh, H., Zhang, T., Song, L., Jermusyk, A., Chung, C. C., Zhu, B., Zhou, W., Matters, G. L., Kurtz, R. C. ... Amundadottir, L. (2018). Characterising cis-regulatory variation in the transcriptome of histologically normal and tumour-derived pancreatic tissues. Gut, 67(3), 521-533. https://doi.org/10.1136/gutjnl-2016-313146

Winczura, K., Schmid, M., Iasillo, C., Molloy, K. R., Harder, L. M., Andersen, J. S., LaCava, J. & Jensen, T. H. (2018). Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions. Cell Reports, 22(1), 44-58. https://doi.org/10.1016/j.celrep.2017.12.037

Schmid, M. & Jensen, T. H. (2018). Controlling nuclear RNA levels. Nature Reviews. Genetics, 19(8), 518-529. https://doi.org/10.1038/s41576-018-0013-2

Imamura, K., Takaya, A., Ishida, Y. I., Fukuoka, Y., Taya, T., Nakaki, R., Kakeda, M., Imamachi, N., Sato, A., Yamada, T., Onoguchi-Mizutani, R., Akizuki, G., Tanu, T., Tao, K., Miyao, S., Suzuki, Y., Nagahama, M., Yamamoto, T., Jensen, T. H. & Akimitsu, N. (2018). Diminished nuclear RNA decay upon Salmonella infection upregulates antibacterial noncoding RNAs. EMBO Journal, 37(13), Artikel e97723. https://doi.org/10.15252/embj.201797723

Schmid, M., Tudek, A. & Jensen, T. H. (2018). Simultaneous Measurement of Transcriptional and Post-transcriptional Parameters by 3′ End RNA-Seq. Cell Reports, 24(9), 2468-2478. https://doi.org/10.1016/j.celrep.2018.07.104

Tudek, A., Lloret-Llinares, M. & Jensen, T. H. (2018). The multitasking polyA tail: nuclear RNA maturation, degradation and export. Philosophical Transactions of the Royal Society B: Biological Sciences, 373(1762), Artikel 20180169. https://doi.org/10.1098/rstb.2018.0169

Silla, T., Karadoulama, E., Mąkosa, D., Lubas, M. & Jensen, T. H. (2018). The RNA Exosome Adaptor ZFC3H1 Functionally Competes with Nuclear Export Activity to Retain Target Transcripts. Cell Reports, 23(7), 2199-2210. https://doi.org/10.1016/j.celrep.2018.04.061

Lloret-Llinares, M., Karadoulama, E., Chen, Y., Wojenski, L. A., Villafano, G. J., Bornholdt, J., Andersson, R., Core, L., Sandelin, A. & Jensen, T. H. (2018). The RNA exosome contributes to gene expression regulation during stem cell differentiation. Nucleic Acids Research, 46(21), 11502-11513. https://doi.org/10.1093/nar/gky817

Rennie, S., Dalby, M., Lloret-Llinares, M., Bakoulis, S., Dalager Vaagensø, C., Heick Jensen, T. & Andersson, R. (2018). Transcription start site analysis reveals widespread divergent transcription in D. melanogaster and core promoter-encoded enhancer activities. Nucleic Acids Research, 46(11), 5455–5469. https://doi.org/10.1093/nar/gky244

2017

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Iasillo, C., Schmid, M., Yahia, Y., Maqbool, M. A., Descostes, N., Karadoulama, E., Bertrand, E., Andrau, J. C. & Jensen, T. H. (2017). ARS2 is a general suppressor of pervasive transcription. Nucleic Acids Research, 45(17), 10229-10241. https://doi.org/10.1093/nar/gkx647

Krogh, N., Pietschmann, M., Schmid, M., Jensen, T. H. & Nielsen, H. (2017). Lariat capping as a tool to manipulate the 5' end of individual yeast mRNA species in vivo. RNA, 23(5), 683-695. https://doi.org/10.1261/rna.059337.116

Giacometti, S., Benbahouche, N. E. H., Domanski, M., Robert, M.-C., Meola, N., Lubas, M., Bukenborg, J., Andersen, J. S., Schulze, W. M., Verheggen, C., Kudla, G., Jensen, T. H. & Bertrand, E. (2017). Mutually Exclusive CBC-Containing Complexes Contribute to RNA Fate. Cell Reports, 18(11), 2635-2650. https://doi.org/10.1016/j.celrep.2017.02.046

Tudek, A., Schmid, M. & Jensen, T. H. (2017). Nuclear Decay Factors Crack Up mRNA. Molecular Cell, 65(5), 775-776. https://doi.org/10.1016/j.molcel.2017.02.014

Kofoed, R. H., Zheng, J., Ferreira, N., Lykke-Andersen, S., Salvi, M., Betzer, C., Reimer, L., Jensen, T. H., Fog, K. & Jensen, P. H. (2017). Polo-like kinase 2 modulates α-synuclein protein levels by regulating its mRNA production. Neurobiology of Disease, 106, 49-62. https://doi.org/10.1016/j.nbd.2017.06.014

Meola, N. & Jensen, T. H. (2017). Targeting the nuclear RNA exosome: Poly(A) binding proteins enter the stage. RNA Biology, 14(7), 820-826. https://doi.org/10.1080/15476286.2017.1312227

2016

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Molleston, J. M., Sabin, L. R., Moy, R. H., Menghani, S. V., Rausch, K., Gordesky-Gold, B., Hopkins, K. C., Zhou, R., Jensen, T. H., Wilusz, J. E. & Cherry, S. (2016). A conserved virus-induced cytoplasmic TRAMP-like complex recruits the exosome to target viral RNA for degradation. Genes & Development, 30(14), 1658-1670. https://doi.org/10.1101/gad.284604.116

Meola, N., Domanski, M., Karadoulama, E., Chen, Y., Gentil, C., Pultz, D., Vitting-Seerup, K., Lykke-Andersen, S., Andersen, J. S., Sandelin, A. & Jensen, T. H. (2016). Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts. Molecular Cell, 64(3), 520-533. https://doi.org/10.1016/j.molcel.2016.09.025

Chen, Y., Pai, A. A., Herudek, J., Lubas, M., Meola, N., Järvelin, A. I., Andersson, R., Pelechano, V., Steinmetz, L. M., Jensen, T. H. & Sandelin, A. (2016). Principles for RNA metabolism and alternative transcription initiation within closely spaced promoters. Nature Genetics, 48(9), 984-994. https://doi.org/10.1038/ng.3616

Domanski, M., Upla, P., Rice, W. J., Molloy, K. R., Ketaren, N. E., Stokes, D. L., Jensen, T. H., Rout, M. P. & Lacava, J. (2016). Purification and analysis of endogenous human RNA exosome complexes. RNA, 22(9), 1467-1475. https://doi.org/10.1261/rna.057760.116

Llinares, M. L., Mapendano, C. K., Martlev, L. H., Lykke-Andersen, S. & Jensen, T. H. (2016). Relationships between PROMPT and gene expression. RNA Biology, 13(1), 6-14. https://doi.org/10.1080/15476286.2015.1109769

Falk, S., Finogenova, K., Sørensen, M. M., Benda, C., Lykke-Andersen, S., Jensen, T. H. & Conti, E. (2016). Structure of the RBM7-ZCCHC8 core of the NEXT complex reveals connections to splicing factors. Nature Communications, 7, Artikel 13573. https://doi.org/10.1038/ncomms13573

2015

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Andersson, R., Chen, Y., Core, L., Lis, J. T., Sandelin, A. & Jensen, T. H. (2015). Human Gene Promoters Are Intrinsically Bidirectional. Molecular Cell, 60(3), 346-347. https://doi.org/10.1016/j.molcel.2015.10.015

Lykke-Andersen, S. & Jensen, T. H. (2015). Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes. Nature Reviews. Molecular Cell Biology, 16, 665-677. https://doi.org/10.1038/nrm4063

Hakhverdyan, Z., Domanski, M., Hough, L. E., Oroskar, A. A., Oroskar, A. R., Keegan, S., Dilworth, D. J., Molloy, K. R., Sherman, V., Aitchison, J. D., Fenyö, D., Chait, B. T., Jensen, T. H., Rout, M. P. & LaCava, J. (2015). Rapid, optimized interactomic screening. Nature Methods, 12(6), 553-560. https://doi.org/10.1038/nmeth.3395

Lubas, M. S., Andersen, P. R., Schein, A., Dziembowski, A., Kudla, G. & Jensen, T. H. (2015). The Human Nuclear Exosome Targeting Complex Is Loaded onto Newly Synthesized RNA to Direct Early Ribonucleolysis. Cell Reports, 10(2), 178-183. https://doi.org/10.1016/j.celrep.2014.12.026

Schmid, M., Olszewski, P., Pelechano, V., Gupta, I., Steinmetz, L. M. & Jensen, T. H. (2015). The Nuclear PolyA-Binding Protein Nab2p Is Essential for mRNA Production. Cell Reports, 12(1), 128-139. https://doi.org/10.1016/j.celrep.2015.06.008

2014

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Andersson, R., Gebhard, C., Miguel-Escalada, I., Hoof, I., Bornholdt, J., Boyd, M., Chen, Y., Zhao, X., Schmidl, C., Suzuki, T., Ntini, E., Arner, E., Valen, E., Li, K., Schwarzfischer, L., Glatz, D., Raithel, J., Lilje, B., Rapin, N. ... FANTOM Consortium (2014). An atlas of active enhancers across human cell types and tissues. Nature, 507, 455-461. https://doi.org/10.1038/nature12787

Lykke-Andersen, S., Chen, Y., Ardal, B., Lilje, B., Waage, J. E., Sandelin, A. G. & Jensen, T. H. (2014). Human nonsense-mediated RNA decay initiates widely by endonucleolysis and targets snoRNA host genes. Genes & Development, 28(22), 2498-2517. https://doi.org/10.1101/gad.246538.114

Andersson, R., Andersen, P. R., Valen, E., Core, L. J., Bornholdt, J., Boyd, M., Heick Jensen, T. & Sandelin, A. (2014). Nuclear stability and transcriptional directionality separate functionally distinct RNA species. Nature Communications, 5, 1-10. Artikel 5336. https://doi.org/10.1038/ncomms6336

Jimeno-González, S., Schmid, M., Malagon, F., Haaning, L. L. & Jensen, T. H. (2014). Rat1p maintains RNA polymerase II CTD phosphorylation balance. RNA, 20(4), 551-558. https://doi.org/10.1261/rna.041129.113

Schmid, M. & Jensen, T. H. (2014). SnapShot: nuclear RNAPII transcript modification. Cell, 157(5), 1244-1244.e1-2. https://doi.org/10.1016/j.cell.2014.05.003

2013

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Hallais, M., Pontvianne, F., Andersen, P. R., Clerici, M., Lener, D., Benbahouche, N. E. H., Gostan, T., Vandermoere, F., Robert, M.-C., Cusack, S., Verheggen, C., Jensen, T. H. & Bertrand, E. (2013). CBC-ARS2 stimulates 3'-end maturation of multiple RNA families and favors cap-proximal processing. Nature Structural and Molecular Biology, 20(12), 1358-1366. https://doi.org/10.1038/nsmb.2720

Jensen, T. H., Jacquier, A. & Libri, D. (2013). Dealing with pervasive transcription. Molecular Cell, 52(4), 473-484. https://doi.org/10.1016/j.molcel.2013.10.032

Lubas, M. S., Damgaard, C. K., Tomecki, R., Cysewski, D., Jensen, T. H. & Dziembowski, A. (2013). Exonuclease hDIS3L2 specifies an exosome-independent 3'-5' degradation pathway of human cytoplasmic mRNA. E M B O Journal, 32(13), 1855-1568. https://doi.org/10.1038/emboj.2013.135

Andersen, P. K., Jensen, T. H. & Lykke-Andersen, S. (2013). Making ends meet: Coordination between RNA 3'end processing and transcription initiation. Wiley Interdisciplinary Reviews: RNA, 4(3), 233-246. https://doi.org/10.1002/wrna.1156

Saguez, C., Zubiate, F. A. G., Schmid, M., Bøggild, A., Latrick, C. M., Malagon, F., Putnam, A., Sanderson, L., Jankowsky, E., Brodersen, D. E. & Jensen, T. H. (2013). Mutational analysis of the yeast RNA helicase Sub2p reveals conserved domains required for growth, mRNA export, and genomic stability. RNA, 19, 1363-1371 . https://doi.org/10.1261/rna.040048.113

Ntini, E., Järvelin, A. I., Bornholdt, J., Chen, Y., Boyd, M., Jørgensen, M., Andersson, R., Hoof, I., Schein, A., Andersen, P. R., Andersen, P. K., Preker, P., Valen, E., Zhao, X., Pelechano, V., Steinmetz, L. M., Sandelin, A. G. & Jensen, T. H. (2013). Polyadenylation site-induced decay of upstream transcripts enforces promoter directionality. Nature Structural and Molecular Biology, 20(8), 923-928. https://doi.org/10.1038/nsmb.2640

Chlebowski, A., Lubas, M. S., Jensen, T. H. & Dziembowski, A. (2013). RNA decay machines: the exosome. BBA Gene Regulatory Mechanisms, 1829(6-7), 552-560. https://doi.org/10.1016/j.bbagrm.2013.01.006

Andersen, P. R., Domanski, M., Kristiansen, M. S., Storvall, H., Ntini, E., Verheggen, C., Schein, A., Bunkenborg, J., Poser, I., Hallais, M., Sandberg, R., Hyman, A., Lacava, J., Rout, M. P., Andersen, J. S., Bertrand, E. & Jensen, T. H. (2013). The human cap-binding complex is functionally connected to the nuclear RNA exosome. Nature Structural and Molecular Biology, 20(12), 1367-1376. https://doi.org/10.1038/nsmb.2703

Schmid, M. & Jensen, T. H. (2013). Transcription-associated quality control of mRNP. BBA General Subjects, 1829(1), 158-168. https://doi.org/10.1016/j.bbagrm.2012.08.012

2012

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Lubas, M. S., Chlebowski , A., Dziembowski , A. & Jensen, T. H. (2012). Biochemistry and Function of the RNA Exosomes. I G. F. Chanfreau & F. Tamanoi (red.), The Enzymes: Eukaryotic RNases and their Partners in RNA Degradation and Biogenesis, Part A (Bind 31, s. 1-30). Elsevier. https://doi.org/10.1016/B978-0-12-404740-2.00001-X

Domanski, M., Molloy, K., Jiang, H., Chait, B. T., Rout, M. P., Jensen, T. H. & LaCava, J. (2012). Improved methodology for the affinity isolation of human protein complexes expressed at near endogenous levels. BioTechniques, 0(0), 1-6. https://doi.org/10.2144/000113864

Düring, L., Thorsen, M., Petersen, D. S., Køster, B., Jensen, T. H. & Holmberg, S. (2012). MRN1 implicates chromatin remodeling complexes and architectural factors in mRNA maturation. PLoS One, 7(9). https://doi.org/10.1371/journal.pone.0044373

Mühlemann, O. & Jensen, T. H. (2012). mRNP quality control goes regulatory. Trends in Genetics, 28(2), 70-77. https://doi.org/10.1016/j.tig.2011.11.001

Kallehauge, T. B., Robert, M.-C., Bertrand, E. & Jensen, T. H. (2012). Nuclear retention prevents premature cytoplasmic appearance of mRNA. Molecular Cell, 48(1), 145-152. https://doi.org/10.1016/j.molcel.2012.07.022

Andersen, P. K., Lykke-Andersen, S. & Jensen, T. H. (2012). Promoter proximal polyadenylation sites reduce transcription activity. Genes & Development, 26, 2169-2179. https://doi.org/10.1101/gad.189126.112

Schmid, M., Poulsen, M. B., Olszewski, P., Pelecano, V., Saguez, C., Gupta, I., Steinmetz, L. M., Moore, C. & Jensen, T. H. (2012). Rrp6p controls mRNA poly(a) tail length and its decoration with poly(a) binding proteins. Molecular Cell, 47(2), 267-280.