Publications

Recent publications

Dilamian, M., Montazer, M., Yousefi, H., Otzen, D. E. & Morshedi, D. (2024). Functional porous protein nanofibrils/polysaccharides aerogel beads for efficient dyes removal from water. Materials Advances, 5(18), 7199-7221. https://doi.org/10.1039/d4ma00380b

Nowak, J. S. & Otzen, D. E. (2024). Helping proteins come in from the cold: 5 burning questions about cold-active enzymes. BBA Advances, 5, Artikel 100104. https://doi.org/10.1016/j.bbadva.2023.100104

Otzen, D. E., Møllebjerg, A., Hinge, M. & Pathak, G. S. (2024). Hvordan opnår vi en bæredygtig plastikkultur? Aktuel Naturvidenskab, 2024(1), 15-18.

Knudsen, L. J., Nielsen, S. D.-H., Dekker, P., Otzen, D. E., Rauh, V. & Larsen, L. B. (2024). Impact of hydrolysis method and lactase preparation on proteolysis and glycation in long-term stored lactose-hydrolysed UHT milk. International Dairy Journal, 154, Artikel 105946. https://doi.org/10.1016/j.idairyj.2024.105946

Knudsen, L. J., Rauh, V., Pedersen, J. N., Dekker, P., Otzen, D. E., Larsen, L. B. & Nielsen, S. D. H. (2024). Insight into protein crosslinking and casein polymerization in pre- and posthydrolyzed lactose-free ultra-high-temperature milk during long-term storage. Journal of Dairy Science, 107(12), 10497-10511. https://doi.org/10.3168/jds.2024-25103

Shahsavari, S., Rad, M. B., Hajiaghajani, A., Rostami, M., Hakimian, F., Jafarzadeh, S., Hasany, M., Collingwood, J. F., Aliakbari, F., Fouladiha, H., Bardania, H., Otzen, D. E. & Morshedi, D. (2024). Magnetoresponsive liposomes applications in nanomedicine: A comprehensive review. Biomedicine & Pharmacotherapy, 181, Artikel 117665. https://doi.org/10.1016/j.biopha.2024.117665

Peña-Díaz, S., Ferreira, P., Ramos, M. J. & Otzen, D. E. (2024). Mining and engineering activity in catalytic amyloids. Methods in Enzymology, 697, 345-422. https://doi.org/10.1016/bs.mie.2024.03.002

Nielsen, J., Lauritsen, J., Pedersen, J. N., Nowak, J. S., Bendtsen, M. K., Kleijwegt, G., Lusser, K., Pitarch, L. C., Moreno, J. V., Schneider, M. M., Krainer, G., Goksøyr, L., Khalifé, P., Kaalund, S. S., Aznar, S., Kjærgaard, M., Sereikaité, V., Strømgaard, K., Knowles, T. P. J. ... Otzen, D. E. (2024). Molecular properties and diagnostic potential of monoclonal antibodies targeting cytotoxic α-synuclein oligomers. npj Parkinson's Disease , 10(1), Artikel 139. https://doi.org/10.1038/s41531-024-00747-6

Adam, L., Kumar, R., Arroyo-Garcia, L. E., Molenkamp, W. H., Nowak, J. S., Klute, H., Farzadfard, A., Alkenayeh, R., Nielsen, J., Biverstål, H., Otzen, D. E., Johansson, J. & Abelein, A. (2024). Specific inhibition of α-synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS. Protein Science, 33(8), Artikel e5091. https://doi.org/10.1002/pro.5091

Žvirblis, M., Sakalauskas, A., Janvand, S. H. A., Dudutienė, V., Žiaunys, M., Sniečkutė, R., Otzen, D. E., Smirnovas, V. & Matulis, D. (2024). Structure-Activity Relationship of Fluorinated Benzenesulfonamides as Inhibitors of Amyloid-β Aggregation. Chemistry - A European Journal, 30(58), Artikel e202402330. https://doi.org/10.1002/chem.202402330

Aliakbari, F., Marzookian, K., Parsafar, S., Hourfar, H., Nayeri, Z., Fattahi, A., Raeiji, M., Boroujeni, N. N., Otzen, D. E. & Morshedi, D. (2024). The impact of hUC MSC-derived exosome-nanoliposome hybrids on α-synuclein fibrillation and neurotoxicity. Science Advances, 10(14), eadl3406. Artikel eadl3406. https://doi.org/10.1126/sciadv.adl3406

Monti, M., Milanetti, E., Frans, M. T., Miotto, M., Di Rienzo, L., Baranov, M. V., Gosti, G., Somavarapu, A. K., Nagaraj, M., Golbek, T. W., Rossing, E., Moons, S. J., Boltje, T. J., van den Bogaart, G., Weidner, T., Otzen, D. E., Tartaglia, G. G., Ruocco, G. & Roeters, S. J. (2024). Two Receptor Binding Strategy of SARS-CoV-2 Is Mediated by Both the N-Terminal and Receptor-Binding Spike Domain. Journal of Physical Chemistry B, 128(2), 451-464. https://doi.org/10.1021/acs.jpcb.3c06258

Andersen, C. B., Lausdahl, A. K., Nielsen, J., Clausen, M. P., Mulder, F. A. A., Otzen, D. E. & Arnspang, E. C. (2023). 4-Oxo-2-nonenal-Induced α-Synuclein Oligomers Interact with Membranes in the Cell, Leading to Mitochondrial Fragmentation. Biochemistry, 62(16), 2417-2425. https://doi.org/10.1021/acs.biochem.3c00114

Ali, S. A., Chung, K. H. K., Forgham, H., Olsen, W. P., Kakinen, A., Balaji, A., Otzen, D. E., Davis, T. P. & Javed, I. (2023). Alzheimer's Progenitor Amyloid-β Targets and Dissolves Microbial Amyloids and Impairs Biofilm Function. Advanced Science, 10(29), Artikel e2301423. https://doi.org/10.1002/advs.202301423

Somavarapu, A. K., Kleijwegt, G., Nagaraj, M., Alam, P., Nielsen, J. & Otzen, D. E. (2023). Drug repurposing screens identify compounds that inhibit α-synuclein oligomers' membrane disruption and block antibody interactions. Chemical Science, 14(11), 3030-3047. https://doi.org/10.1039/d2sc05534a

Roeters, S. J., Strunge, K., Pedersen, K. B., Golbek, T. W., Bregnhøj, M., Zhang, Y., Wang, Y., Dong, M., Nielsen, J., Otzen, D. E., Schiøtt, B. & Weidner, T. (2023). Elevated concentrations cause upright alpha-synuclein conformation at lipid interfaces. Nature Communications, 14(1), Artikel 5731. https://doi.org/10.1038/s41467-023-39843-1

Rasmussen, H. Ø., Kumar, A., Shin, B., Stylianou, F., Sewell, L., Xu, Y., Otzen, D. E., Pedersen, J. S. & Matthews, S. J. (2023). FapA is an Intrinsically Disordered Chaperone for Pseudomonas Functional Amyloid FapC. Journal of Molecular Biology, 435(2), Artikel 167878. https://doi.org/10.1016/j.jmb.2022.167878

Evans, D. C. S., Khamas, A. B., Marcussen, L., Rasmussen, K. S., Klitgaard, J. K., Kallipolitis, B. H., Nielsen, J., Otzen, D. E., Leake, M. C. & Meyer, R. L. (2023). GFP fusions of Sec-routed extracellular proteins in Staphylococcus aureusreveal surface-associated coagulase in biofilms. Microbial Cell, 10(7), 145-156. https://doi.org/10.15698/mic2023.07.800

Alijanvand, S. H., Ladefoged, L. K., Zubrienė, A., Sakalauskas, A., Christiansen, G., Dudutiene, V., Schiøtt, B., Matulis, D., Smirnovas, V. & Otzen, D. E. (2023). Inhibitory effects of fluorinated benzenesulfonamides on insulin fibrillation. International Journal of Biological Macromolecules, 227, 590-600. https://doi.org/10.1016/j.ijbiomac.2022.12.105

Singh, Y., Trautwein, C., Romani, J., Salker, M. S., Neckel, P. H., Fraccaroli, I., Abeditashi, M., Woerner, N., Admard, J., Dhariwal, A., Dueholm, M. K. D., Schäfer, K. H., Lang, F., Otzen, D. E., Lashuel, H. A., Riess, O. & Casadei, N. (2023). Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease. Molecular Neurodegeneration, 18(1), Artikel 44. https://doi.org/10.1186/s13024-023-00628-1

Rusbjerg-Weberskov, C. E., Johansen, M. L., Nowak, J. S., Otzen, D., Pedersen, J. S., Enghild, J. J. & Nielsen, N. S. (2023). Periostin C-Terminal Is Intrinsically Disordered and Interacts with 143 Proteins in an In Vitro Epidermal Model of Atopic Dermatitis. Biochemistry, 62(19), 2803-2815. https://doi.org/10.1021/acs.biochem.3c00176

López Hernández, M., Pedersen, J. S. & Otzen, D. E. (2023). Proteins and biosurfactants: Structures, functions, and recent applications. Current Opinion in Colloid & Interface Science, 68, Artikel 101746. https://doi.org/10.1016/j.cocis.2023.101746

Sønderby, T. V., Louros, N. N., Khodaparast, L., Khodaparast, L., Madsen, D. J., Olsen, W. P., Moonen, N., Nagaraj, M., Sereikaite, V., Strømgaard, K., Rousseau, F., Schymkowitz, J. & Otzen, D. E. (2023). Sequence-targeted Peptides Divert Functional Bacterial Amyloid Towards Destabilized Aggregates and Reduce Biofilm Formation. Journal of Molecular Biology, 435(11), 168039. Artikel 168039. https://doi.org/10.1016/j.jmb.2023.168039

Rasmussen, H. Ø., Nielsen, J., de Poli, A., Otzen, D. E. & Pedersen, J. S. (2023). Tau Fibrillation Induced by Heparin or a Lysophospholipid Show Different Initial Oligomer Formation. Journal of Molecular Biology, 435(17), Artikel 168194. https://doi.org/10.1016/j.jmb.2023.168194

Pirhaghi, M., Najarzadeh, Z., Moosavi-Movahedi, F., Shafizadeh, M., Mamashli, F., Atarod, D., Ghasemi, A., Morshedi, D., Meratan, A. A., Otzen, D. E. & Saboury, A. A. (2023). The anti-platelet drug ticlopidine inhibits FapC fibrillation and biofilm production: Highlighting its antibiotic activity. Biochimica et Biophysica Acta - Proteins and Proteomics, 1871(2), Artikel 140883. https://doi.org/10.1016/j.bbapap.2022.140883

Hourfar, H., Aliakbari, F., Aqdam, S. R., Nayeri, Z., Bardania, H., Otzen, D. E. & Morshedi, D. (2023). The impact of α-synuclein aggregates on blood-brain barrier integrity in the presence of neurovascular unit cells. International Journal of Biological Macromolecules, 229, 305-320. https://doi.org/10.1016/j.ijbiomac.2022.12.134

Pathak, G. S., Hinge, M. & Otzen, D. (2023). Transdisciplinary Pragmatic Melioration for the Plastic Life Cycle: Why the Social, Natural, and Technical Sciences Should Prioritize Reducing Harm. Science of the Total Environment, 895, Artikel 165154. https://doi.org/10.1016/j.scitotenv.2023.165154

He, J., Steffen, J. H., Thulstrup, P. W., Pedersen, J. N., Sauerland, M. B., Otzen, D. E., Hawkins, C. L., Gourdon, P., Davies, M. J. & Hägglund, P. (2022). Anastellin impacts on the processing of extracellular matrix fibronectin and stimulates release of cytokines from coronary artery smooth muscle cells. Scientific Reports, 12(1), Artikel 22051. https://doi.org/10.1038/s41598-022-26359-9

Pirhaghi, M., Frank, S. A., Alam, P., Nielsen, J., Sereikaite, V., Gupta, A., Strømgaard, K., Andreasen, M., Sharma, D., Saboury, A. A. & Otzen, D. E. (2022). A penetratin-derived peptide reduces the membrane permeabilization and cell toxicity of α-synuclein oligomers. Journal of Biological Chemistry, 298(12), Artikel 102688. https://doi.org/10.1016/j.jbc.2022.102688

Mohammad-Beigi, H., Zanganeh, M., Scavenius, C., Eskandari, H., Farzadfard, A., Shojaosadati, S. A., Enghild, J. J., Otzen, D. E., Buell, A. K. & Sutherland, D. S. (2022). A Protein Corona Modulates Interactions of α-Synuclein with Nanoparticles and Alters the Rates of the Microscopic Steps of Amyloid Formation. ACS Nano, 16(1), 1102-1118. https://doi.org/10.1021/acsnano.1c08825

Kjærgaard, M., Rasmussen, L. S., Vinther, J. N., Andersen, K. R., Andersen, E. S., Lorentzen, E., Thirup, S. S., Otzen, D. & Brodersen, D. E. (2022). A Semester-Long Learning Path Teaching Computational Skills via Molecular Graphics in PyMOL. The Biophysicist, 3(2), 106–114. https://doi.org/10.35459/tbp.2022.000219

Christensen, N. R., Pedersen, C. P., Sereikaite, V., Pedersen, J. N., Vistrup-Parry, M., Sørensen, A. T., Otzen, D., Teilum, K., Madsen, K. L. & Strømgaard, K. (2022). Bidirectional protein-protein interactions control liquid-liquid phase separation of PSD-95 and its interaction partners. iScience, 25(2), Artikel 103808. https://doi.org/10.1016/j.isci.2022.103808

Nagaraj, M., Najarzadeh, Z., Pansieri, J., Biverstål, H., Musteikyte, G., Smirnovas, V., Matthews, S., Emanuelsson, C., Johansson, J., Buxbaum, J. N., Morozova-Roche, L. & Otzen, D. E. (2022). Chaperones mainly suppress primary nucleation during formation of functional amyloid required for bacterial biofilm formation. Chemical Science, 13(2), 536-553. https://doi.org/10.1039/d1sc05790a

Nayeri, Z., Aliakbari, F., Afzali, F., Parsafar, S., Gharib, E., Otzen, D. E. & Morshedi, D. (2022). Characterization of exogenous αSN response genes and their relation to Parkinson's disease using network analyses. Frontiers in Pharmacology, 13, Artikel 966760. https://doi.org/10.3389/fphar.2022.966760

Grønnemose, A. L., Østerlund, E. C., Otzen, D. E. & Jørgensen, T. J. D. (2022). EGCG has Dual and Opposing Effects on the N-terminal Region of Self-associating α-synuclein Oligomers. Journal of Molecular Biology, 434(23), Artikel 167855. https://doi.org/10.1016/j.jmb.2022.167855

Sønderby, T. V., Rasmussen, H. Ø., Frank, S. A., Skov Pedersen, J. & Otzen, D. E. (2022). Folding steps in the fibrillation of functional amyloid: denaturant sensitivity reveals common features in nucleation and elongation. Journal of Molecular Biology, 434(2), Artikel 167337. https://doi.org/10.1016/j.jmb.2021.167337

Otzen, D. E. (2022). Functional amyloid in a lipid-like environment: a merry dance of many steps. Essays in Biochemistry, 66(7), 1035-1046. https://doi.org/10.1042/EBC20220062

Sønderby, T. V., Najarzadeh, Z. & Otzen, D. E. (2022). Functional Bacterial Amyloids: Understanding Fibrillation, Regulating Biofilm Fibril Formation and Organizing Surface Assemblies. Molecules, 27(13), Artikel 4080. https://doi.org/10.3390/molecules27134080

Farzadfard, A., König, A., Petersen, S. V., Nielsen, J., Vasili, E., Dominguez-Meijide, A., Buell, A. K., Outeiro, T. F. & Otzen, D. E. (2022). Glycation modulates alpha-synuclein fibrillization kinetics: a sweet spot for inhibition. The Journal of Biological Chemistry, 298(5), Artikel 101848. https://doi.org/10.1016/j.jbc.2022.101848

Otzen, D. E., Pedersen, J. N., Rasmussen, H. Ø. & Pedersen, J. S. (2022). How do surfactants unfold and refold proteins? Advances in Colloid and Interface Science, 308, Artikel 102754. https://doi.org/10.1016/j.cis.2022.102754

Rasmussen, H. Ø., Otzen, D. E. & Pedersen, J. S. (2022). Induction, inhibition, and incorporation: Different roles for anionic and zwitterionic lysolipids in the fibrillation of the functional amyloid FapC. The Journal of Biological Chemistry, 298(2), Artikel 101569. https://doi.org/10.1016/j.jbc.2022.101569

Najarzadeh, Z., Mohammad-Beigi, H., Pedersen, J. N., Christiansen, G., Pedersen, J. S., Nielsen, J. & Otzen, D. E. (2022). Interaction of membrane vesicles with the Pseudomonas functional amyloid protein FapC facilitates amyloid formation. BBA Advances, 2, Artikel 100055. https://doi.org/10.1016/j.bbadva.2022.100055

Reimer, L., Haikal, C., Gram, H., Theologidis, V., Kovacs, G., Ruesink, H., Baun, A., Nielsen, J., Otzen, D. E., Li, J.-Y. & Jensen, P. H. (2022). Low dose DMSO treatment induces oligomerization and accelerates aggregation of α-synuclein. Scientific Reports, 12, Artikel 3737. https://doi.org/10.1038/s41598-022-07706-2

Sønderby, T. V., Zou, Y., Wang, P., Wang, C. & Otzen, D. E. (2022). Molecular-level insights into the surface-induced assembly of Functional Bacterial Amyloid. Biophysical Journal, 121(18), 3422-3434. https://doi.org/10.1016/j.bpj.2022.08.013

Alam, P., Holst, M. R., Lauritsen, L., Nielsen, J., Nielsen, S. S. E., Jensen, P. H., Brewer, J. R., Otzen, D. E. & Nielsen, M. S. (2022). Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers. Fluids and Barriers of the CNS, 19(1), Artikel 37. https://doi.org/10.1186/s12987-022-00334-y

Sahin, C., Østerlund, E. C., Österlund, N., Costeira-Paulo, J., Pedersen, J. N., Christiansen, G., Nielsen, J., Grønnemose, A. L., Amstrup, S. K., Tiwari, M. K., Rao, R. S. P., Bjerrum, M. J., Ilag, L. L., Davies, M. J., Marklund, E. G., Pedersen, J. S., Landreh, M., Møller, I. M., Jørgensen, T. J. D. & Otzen, D. E. (2022). Structural Basis for Dityrosine-Mediated Inhibition of α-Synuclein Fibrillization. Journal of the American Chemical Society, 144(27), 11949-11954. https://doi.org/10.1021/jacs.2c03607

Bisiak, F., Chrenková, A., Zhang, S. D., Pedersen, J. N., Otzen, D. E., Zhang, Y. E. & Brodersen, D. E. (2022). Structural variations between small alarmone hydrolase dimers support different modes of regulation of the stringent response. Journal of Biological Chemistry, 298(7), Artikel 102142. https://doi.org/10.1016/j.jbc.2022.102142

Rasmussen, H. Ø., Wollenberg, D. T. W., Wang, H., Andersen, K. K., Oliveira, C. L. P., Jørgensen, C. I., Jørgensen, T. J. D., Otzen, D. E. & Pedersen, J. S. (2022). The changing face of SDS denaturation: Complexes of Thermomyces lanuginosus lipase with SDS at pH 4.0, 6.0 and 8.0. Journal of Colloid and Interface Science, 614, 214-232. https://doi.org/10.1016/j.jcis.2021.12.188

Farzadfard, A., Pedersen, J. N., Meisl, G., Somavarapu, A. K., Alam, P., Goksøyr, L., Nielsen, M. A., Sander, A. F., Knowles, T. P. J., Pedersen, J. S. & Otzen, D. E. (2022). The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization. Communications Biology, 5(1), 123. Artikel 123. https://doi.org/10.1038/s42003-022-03059-8

Dyla, M., González Foutel, N. S., Otzen, D. E. & Kjaergaard, M. (2022). The optimal docking strength for reversibly tethered kinases. Proceedings of the National Academy of Sciences (PNAS), 119(25), Artikel e2203098119. https://doi.org/10.1073/pnas.2203098119

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Viktor Hauge Ladegaard