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Oscar Gabriel Sevillano Quispe: With a little help from my C-terminal domain – NMDA receptor function and allosteric modulation

PhD defence, Wednesday 30 November 2022, Oscar Gabriel Sevillano Quispe

Oscar Gabriel Sevillano Quispe

During his studies, Oscar Gabriel Sevillano Quispe researched structural features of NMDA receptors that affect its function. NMDA receptors are important because they are involved in synaptic formation and maintenance, and their dysfunction is associated with several neurological diseases. Oscar Gabriel Sevillano Quispe studied how positively charged amino acids of one region of the NMDA receptor, called C-terminal domain, regulate channel properties and response to modulatory compounds.

Although clusters of positive residues in the C-terminal domain have mostly been regarded as trafficking signals, the new studies show that they are important also for NMDA receptor pharmacology and channel properties.

The PhD degree was completed at the Department of Molecular Biology and Genetics, Faculty of Natural Sciences, Aarhus University.

This summary was prepared by the PhD student.

Time: Wednesday 30th of November, 2022 at 12:00
Place: Building 1593, room 012, iNano auditorium, The iNano House, Aarhus University, Gustav Wieds Vej  14, 8000 Aarhus C.
Title of dissertation: Studies on the C-terminal domain of the NMDA receptor subunit GluN1: allosteric modulation and channel properties

Contact information: Oscar Gabriel Sevillano Quispe, e-mail: ogsq@mbg.au.dk, tel.: +45 52 68 84 10
Members of the assessment committee:
Associate Professor Kasper Bø Hansen, Division of Biological Sciences, University of Montana, USA

Associate Professor Anders Skov Kristensen, Department of Drug Design and Pharmacology, University of Copenhagen, Denmark

Associate Professor Knud Erik Larsen (chair), Department of Molecular Biology and Genetics, Aarhus University, Denmark
Main supervisor:
Associate Professor Hanne Poulsen, Department of Molecular Biology and Genetics, Aarhus University, Denmark
Helle Bakke Krog, PhD, Department of Molecular Biology and Genetics, Aarhus University, Denmark
Language: The PhD dissertation will be defended in English
The defence is public.
The PhD thesis is available for reading at the Graduate School of Natural Sciences/GSNS, Jens Baggesens Vej 53, building 5221, 8200 Aarhus N.