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Jepsen, M. R., Østergaard, J. A., Conover, C. A., Wogensen, L., Birn, H., Krag, S. P., Fenton, R. A. & Oxvig, C. (2022). Increased activity of the metalloproteinase PAPP-A promotes diabetes-induced glomerular hypertrophy. Metabolism: Clinical and Experimental, 132, [155218]. https://doi.org/10.1016/j.metabol.2022.155218

Jensen, R. K., Pedersen, H., Lorentzen, J., Laursen, N. S., Vorup-Jensen, T. & Andersen, G. R. (2022). Structural insights into the function-modulating effects of nanobody binding to the integrin receptor α_Mβ₂. Journal of Biological Chemistry, 298(8), [102168]. https://doi.org/10.1016/j.jbc.2022.102168

Jankowski, V., Saritas, T., Kjolby, M., Hermann, J., Speer, T., Himmelsbach, A., Mahr, K., Heuschkel, M. A., Schunk, S. J., Thirup, S., Winther, S., Bottcher, M., Nyegard, M., Nykjaer, A., Kramann, R., Kaesler, N., Jankowski, J., Floege, J., Marx, N. & Goettsch, C. (2022). Carbamylated sortilin associates with cardiovascular calcification in patients with chronic kidney disease. Kidney International, 101(3), 574-584. https://doi.org/10.1016/j.kint.2021.10.018

Jakobsen, A. K., Yuusufi, S., Madsen, L. B., Meldgaard, P., Knudsen, B. R. & Stougaard, M. (2022). TDP1 and TOP1 as targets in anticancer treatment of NSCLC: Activity and protein level in normal and tumor tissue from 150 NSCLC patients correlated to clinical data. Lung Cancer, 164, 23-32. https://doi.org/10.1016/j.lungcan.2021.12.010

He, J., Steffen, J. H., Thulstrup, P. W., Pedersen, J. N., Sauerland, M. B., Otzen, D. E., Hawkins, C. L., Gourdon, P., Davies, M. J. & Hägglund, P. (2022). Anastellin impacts on the processing of extracellular matrix fibronectin and stimulates release of cytokines from coronary artery smooth muscle cells. Scientific Reports, 12(1), 22051. https://doi.org/10.1038/s41598-022-26359-9

Harwood, S. L., Diep, K., Nielsen, N. S., Jensen, K. T. & Enghild, J. J. (2022). The conformational change of the protease inhibitor α₂-macroglobulin is triggered by the retraction of the cleaved bait region from a central channel. Journal of Biological Chemistry, 298(8), [102230]. https://doi.org/10.1016/j.jbc.2022.102230

Harwood, S. L., Andersen, G. R. & Enghild, J. J. (2022). Recent cryogenic electron microscopy structures of human A2M may not be representative of the native protein. Proceedings of the National Academy of Sciences of the United States of America, 119(37), [e2210218119]. https://doi.org/10.1073/pnas.2210218119

Hartmann, S., Ling, M., Dreyer, L. S. A., Zipori, A., Finster, K., Grawe, S., Jensen, L. Z., Borck, S., Reicher, N., Niedermeier, D., Jones, N. C., Hoffmann, S. V., Wex, H., Rudich, Y., Boesen, T. & Santl-Temkiv, T. (2022). Structure and Protein-Protein Interactions of Ice Nucleation Proteins Drive Their Activity. Frontiers in Microbiology, 13, [872306]. https://doi.org/10.3389/fmicb.2022.872306

Hansen, E. K. B., Fredsøe, J. H., Okholm, T. L. H., Ulhøi, B. P., Klingenberg, S., Jensen, J. B., Kjems, J., Bouchelouche, K., Borre, M., Damgaard, C. K., Pedersen, J. S., Kristensen, L. S. & Sørensen, K. D. (2022). The transcriptional landscape and biomarker potential of circular RNAs in prostate cancer. Genome Medicine, 14(1), [8]. https://doi.org/10.1186/s13073-021-01009-3

Hansen, S. B. & Andersen, K. R. (2022). Introducing Cysteines into Nanobodies for Site-Specific Labeling. In G. Hussack & K. A. Henry (Eds.), Single-Domain Antibodies: Methods and Protocols (pp. 327-343). Humana Press. Methods in Molecular Biology Vol. 2446 https://doi.org/10.1007/978-1-0716-2075-5_16

Hangiu, O., Compte, M., Dinesen, A., Navarro, R., Tapia-Galisteo, A., Mandrup, O. A., Erce-Llamazares, A., Lázaro-Gorines, R., Nehme-Álvarez, D., Domínguez-Alonso, C., Harwood, S. L., Alfonso, C., Blanco, B., Rubio-Pérez, L., Jiménez-Reinoso, A., Díez-Alonso, L., Blanco, F. J., Sanz, L., Howard, K. A. & Álvarez-Vallina, L. (2022). Tumor targeted 4-1BB agonist antibody-albumin fusions with high affinity to FcRn induce anti-tumor immunity without toxicity. iScience, 25(9), [104958]. https://doi.org/10.1016/j.isci.2022.104958

Gómez-Cuadrado, L., Bullock, E., Mabruk, Z., Zhao, H., Souleimanova, M., Noer, P. R., Turnbull, A. K., Oxvig, C., Bertos, N., Byron, A., Dixon, J. M., Park, M., Haider, S., Natrajan, R., Sims, A. H. & Brunton, V. G. (2022). Characterisation of the Stromal Microenvironment in Lobular Breast Cancer. Cancers, 14(4), [904]. https://doi.org/10.3390/cancers14040904

Gupta, K. J., Kaladhar, V. C., Fitzpatrick, T. B., Fernie, A. R., Møller, I. M. & Loake, G. J. (2022). Nitric oxide regulation of plant metabolism. Molecular Plant, 15(2), 228-242. https://doi.org/10.1016/j.molp.2021.12.012

Gultom, M., Kratzel, A., Portmann, J., Stalder, H., Chanfon Bätzner, A., Gantenbein, H., Gurtner, C., Ebert, N., Gad, H. H., Hartmann, R., Posthaus, H., Zanolari, P., Pfaender, S., Thiel, V. & Dijkman, R. (2022). Establishment of well-differentiated camelid airway cultures to study Middle East respiratory syndrome coronavirus. Scientific Reports, 12(1), [10340]. https://doi.org/10.1038/s41598-022-13777-y

Gu, T., Just, J., Stenz, K. T., Yan, Y., Sieljacks, P., Wang, J., Groennebaek, T. S., Jakobsgaard, J. E., Rindom, E., Herskind, J., Gravholt, A., Lassen, T. R., Jørgensen, M., Bæk, R., Gutiérrez-Jiménez, E., Iversen, N. K., Rasmussen, P. M., Nyengaard, J. R., Jørgensen, M. M. ... Drasbek, K. R. (2022). The Role of Plasma Extracellular Vesicles in Remote Ischemic Conditioning and Exercise-Induced Ischemic Tolerance. International Journal of Molecular Sciences , 23(6), [3334]. https://doi.org/10.3390/ijms23063334

Grønnemose, A. L., Østerlund, E. C., Otzen, D. E. & Jørgensen, T. J. D. (2022). EGCG has Dual and Opposing Effects on the N-terminal Region of Self-associating α-synuclein Oligomers. Journal of Molecular Biology, 434(23), [167855]. https://doi.org/10.1016/j.jmb.2022.167855

Gomes-Duarte, A., Venø, M. T., de Wit, M., Senthilkumar, K., Broekhoven, M. H., van den Herik, J., Heeres, F. R., van Rossum, D., Rybiczka-Tesulov, M., Legnini, I., van Rijen, P. C., van Eijsden, P., Gosselaar, P. H., Rajewsky, N., Kjems, J., Vangoor, V. R. & Pasterkamp, R. J. (2022). Expression of Circ_Satb1 Is Decreased in Mesial Temporal Lobe Epilepsy and Regulates Dendritic Spine Morphology. Frontiers in Molecular Neuroscience, 15, [832133]. https://doi.org/10.3389/fnmol.2022.832133

Gockert, M., Schmid, M., Jakobsen, L., Jens, M., Andersen, J. S. & Jensen, T. H. (2022). Rapid factor depletion highlights intricacies of nucleoplasmic RNA degradation. Nucleic Acids Research, 50(3), 1583-1600. https://doi.org/10.1093/nar/gkac001

Gierlicka, I., Rattan, S. & Wnuk, M. (2022). Perspectives on using bacteriophages in biogerontology research and interventions  . Chemico-Biological Interactions, 366, [110098]. https://doi.org/10.1016/j.cbi.2022.110098

Gholami-Mahtaj, L., Salimi, M., Nazari, M., Tabasi, F., Bamdad, S., Dehdar, K., Mikaili, M., Mahdaviani, S. A., Salari, F., Lookzadeh, S., Jamaati, H., Salimi, A. & Raoufy, M. R. (2022). Asthma induces psychiatric impairments in association with default mode and salience networks alteration: A resting-state EEG study. Respiratory Physiology and Neurobiology, 300, [103870]. https://doi.org/10.1016/j.resp.2022.103870

Gerlach, P., Garland, W., Lingaraju, M., Salerno-Kochan, A., Bonneau, F., Basquin, J., Jensen, T. H. & Conti, E. (2022). Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome. Molecular Cell, 82(13), 2505-2518.e7. https://doi.org/10.1016/j.molcel.2022.04.011

Garland, W., Müller, I., Wu, M., Schmid, M., Imamura, K., Rib, L., Sandelin, A., Helin, K. & Jensen, T. H. (2022). Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression. Molecular Cell, 82(9), 1691-1707.e8. https://doi.org/10.1016/j.molcel.2022.03.004

Fukai, E., Yoshikawa, M., Shah, N., Sandal, N., Miyao, A., Ono, S., Hirakawa, H., Akyol, T. Y., Umehara, Y., Nonomura, K-I., Stougaard, J., Hirochika, H., Hayashi, M., Sato, S., Andersen, S. U. & Okazaki, K. (2022). Widespread and transgenerational retrotransposon activation in inter- and intra-species recombinant inbred populations of Lotus japonicus. The Plant Journal, 111(5), 1397-1410. https://doi.org/10.1111/tpj.15896

Fuertes, M., Selas, A., Trejo, A., Knudsen, B. R., Palacios, F. & Alonso, C. (2022). Synthesis of hybrid phosphorated indenoquinolines and biological evaluation as topoisomerase I inhibitors and antiproliferative agents. Bioorganic and Medicinal Chemistry Letters, 57, [128517]. https://doi.org/10.1016/j.bmcl.2021.128517

Fuchs, E., Rudnik-Jansen, I., Dinesen, A., Selnihhin, D., Mandrup, O. A., Thiam, K., Kjems, J., Pedersen, F. S. & Howard, K. A. (2022). An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension. Acta Biomaterialia, 153, 411-418. https://doi.org/10.1016/j.actbio.2022.09.048

Fruergaard, M. U., Dach, I., Andersen, J. L., Ozol, M., Shasavar, A., Quistgaard, E. M. H., Poulsen, H., Fedosova, N. & Nissen, P. (2022). The Na,K-ATPase in complex with beryllium fluoride mimics an ATPase phosphorylated state. Journal of Biological Chemistry, 298(9), [102317]. https://doi.org/10.1016/j.jbc.2022.102317

Frank, M., Cortleven, A., Pěnčík, A., Novak, O. & Schmülling, T. (2022). The Photoperiod Stress Response in Arabidopsis thaliana Depends on Auxin Acting as an Antagonist to the Protectant Cytokinin. International Journal of Molecular Sciences , 23(6). https://doi.org/10.3390/ijms23062936

Fonager, S. V., Winther, G., Wittenborn, T. R., Jensen, L., Fahlquist-Hagert, C., Hansen, L. A., Füchtbauer, E-M., Romero-Ramos, M. & Degn, S. E. (2022). Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspring. Journal of Neuroimmunology, 370, [577927]. https://doi.org/10.1016/j.jneuroim.2022.577927

Fjelstrup, S., Dupont, D. M., Bus, C., Enghild, J. J., Jensen, J. B., Birkenkamp-Demtröder, K., Dyrskjøt, L. & Kjems, J. (2022). Differential RNA aptamer affinity profiling on plasma as a potential diagnostic tool for bladder cancer. NAR cancer, 4(3), [zcac025]. https://doi.org/10.1093/narcan/zcac025

Fields, B., Moffat, E. K., Harrison, E., Andersen, S. U., Young, J. P. W. & Friman, V-P. (2022). Genetic variation is associated with differences in facilitative and competitive interactions in the Rhizobium leguminosarum species complex. Environmental Microbiology, 24(8), 3463-3485. https://doi.org/10.1111/1462-2920.15720

Ferrando, B., Møller, I. M. & Stevnsner, T. (2022). Measuring the Activity of DNA Repair Enzymes in Isolated Mitochondria. In Plant Mitochondria (pp. 321-334). Humana Press. Methods in Molecular Biology Vol. 2363 https://doi.org/10.1007/978-1-0716-1653-6_21

Farzadfard, A., Pedersen, J. N., Meisl, G., Somavarapu, A. K., Alam, P., Goksøyr, L., Nielsen, M. A., Sander, A. F., Knowles, T. P. J., Pedersen, J. S. & Otzen, D. E. (2022). The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization. Communications Biology, 5(1), [123]. https://doi.org/10.1038/s42003-022-03059-8

Farzadfard, A., König, A., Petersen, S. V., Nielsen, J., Vasili, E., Dominguez-Meijide, A., Buell, A. K., Outeiro, T. F. & Otzen, D. E. (2022). Glycation modulates alpha-synuclein fibrillization kinetics: a sweet spot for inhibition. The Journal of Biological Chemistry, 298(5), [101848]. https://doi.org/10.1016/j.jbc.2022.101848

Dyla, M., González Foutel, N. S., Otzen, D. E. & Kjaergaard, M. (2022). The optimal docking strength for reversibly tethered kinases. Proceedings of the National Academy of Sciences of the United States of America, 119(25), [e2203098119]. https://doi.org/10.1073/pnas.2203098119

Duncan, C. J. A., Skouboe, M. K., Howarth, S., Hollensen, A. K., Chen, R., Børresen, M. L., Thompson, B. J., Stremenova Spegarova, J., Hatton, C. F., Stæger, F. F., Andersen, M. K., Whittaker, J., Paludan, S. R., Jørgensen, S. E., Thomsen, M. K., Mikkelsen, J. G., Heilmann, C., Buhas, D., Øbro, N. F. ... Mogensen, T. H. (2022). Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic. The Journal of Experimental Medicine, 219(6), [e20212427]. https://doi.org/10.1084/jem.20212427

Dijkman, R., Verma, A. K., Selvaraj, M., Ghimire, R., Gad, H. H., Hartmann, R., More, S., Perlman, S., Thiel, V. & Channappanavar, R. (2022). Effective Interferon Lambda Treatment Regimen To Control Lethal MERS-CoV Infection in Mice. Journal of Virology, 96(11), [e00364-22]. https://doi.org/10.1128/jvi.00364-22

Dieudonné, T., Herrera, S. A., Laursen, M. J., Lejeune, M., Stock, C., Slimani, K., Jaxel, C., Lyons, J. A., Montigny, C., Pomorski, T. G., Nissen, P. & Lenoir, G. (2022). Autoinhibition and regulation by phosphoinositides of ATP8B1, a human lipid flippase associated with intrahepatic cholestatic disorders. eLife, 11, [e75272]. https://doi.org/10.7554/eLife.75272

Dahl, M., Husby, S., Eskelund, C. W., Besenbacher, S., Fjelstrup, S., Côme, C., Ek, S., Kolstad, A., Räty, R., Jerkeman, M., Geisler, C. H., Kjems, J., Kristensen, L. S. & Grønbæk, K. (2022). Expression patterns and prognostic potential of circular RNAs in mantle cell lymphoma: a study of younger patients from the MCL2 and MCL3 clinical trials. Leukemia, 36(1), 177-188. https://doi.org/10.1038/s41375-021-01311-4

Cortleven, A., Roeber, V. M., Frank, M., Bertels, J., Lortzing, V., Beemster, G. T. S. & Schmülling, T. (2022). Photoperiod Stress in Arabidopsis thaliana Induces a Transcriptional Response Resembling That of Pathogen Infection. Frontiers in Plant Science, 13, [838284]. https://doi.org/10.3389/fpls.2022.838284

Christensen, N. R., Pedersen, C. P., Sereikaite, V., Pedersen, J. N., Vistrup-Parry, M., Sørensen, A. T., Otzen, D., Teilum, K., Madsen, K. L. & Strømgaard, K. (2022). Bidirectional protein-protein interactions control liquid-liquid phase separation of PSD-95 and its interaction partners. iScience, 25(2), [103808]. https://doi.org/10.1016/j.isci.2022.103808

Cavassim, M. I. A., Baker, Z., Hoge, C., Schierup, M. H., Schumer, M. & Przeworski, M. (2022). PRDM9 losses in vertebrates are coupled to those of paralogs ZCWPW1 and ZCWPW2. PNAS (Proceedings of the National Academy of Sciences of the United States of America), 119(9), [e2114401119]. https://doi.org/10.1073/pnas.2114401119

Cai, Z., Wu, X., Thomsen, B. & Sahana, G. (2022). Fine-mapping young-stock survival QTL on chromosome 6 in Nordic Red Dairy Cattle. In WCGALP 2022 Programme book Wageningen Academic Publishers. https://www.wageningenacademic.com/pb-assets/wagen/WCGALP2022/66_006.pdf

Bush, J. A., Meyer, S. M., Fuerst, R., Tong, Y., Li, Y., Benhamou, R. I., Aikawa, H., Zanon, P. R. A., Gibaut, Q. M. R., Angelbello, A. J., Gendron, T. F., Zhang, Y. J., Petrucelli, L., Heick Jensen, T., Childs-Disney, J. L. & Disney, M. D. (2022). A blood-brain penetrant RNA-targeted small molecule triggers elimination of r(G₄C₂)^exp in c9ALS/FTD via the nuclear RNA exosome. Proceedings of the National Academy of Sciences of the United States of America, 119(48), [e2210532119]. https://doi.org/10.1073/pnas.2210532119

Busato, S., Gordon, M., Chaudhari, M., Thorsgaard Jensen, I., Akyol, T. Y., Andersen, S. U. & Williams, C. (2022). Compositionality, sparsity, spurious heterogeneity, and other data-driven challenges for machine learning algorithms within plant microbiome studies. Current Opinion in Plant Biology, 71. https://doi.org/10.1016/j.pbi.2022.102326

Braunger, K., Ahn, J., Jore, M. M., Johnson, S., Tang, T. T. L., Pedersen, D. V., Andersen, G. R. & Lea, S. M. (2022). Structure and function of a family of tick-derived complement inhibitors targeting properdin. Nature Communications, 13, [317]. https://doi.org/10.1038/s41467-021-27920-2

Blevins, A. S., Bassett, D. S., Scott, E. K. & Vanwalleghem, G. C. (2022). From calcium imaging to graph topology. Network Neuroscience, 6(4), 1125-1147. https://doi.org/10.1162/netn_a_00262

Blanco, B., Ramírez-Fernández, Á., Bueno, C., Argemí-Muntadas, L., Fuentes, P., Aguilar-Sopeña, Ó., Gutierrez-Agüera, F., Zanetti, S. R., Tapia-Galisteo, A., Díez-Alonso, L., Segura-Tudela, A., Castellá, M., Marzal, B., Betriu, S., Harwood, S. L., Compte, M., Lykkemark, S., Erce-Llamazares, A., Rubio-Pérez, L. ... Álvarez-Vallina, L. (2022). Overcoming CAR-Mediated CD19 Downmodulation and Leukemia Relapse with T Lymphocytes Secreting Anti-CD19 T-cell Engagers. Cancer Immunology Research, 10(4), 498-511. https://doi.org/10.1158/2326-6066.CIR-21-0853

Bisiak, F., Chrenková, A., Zhang, S. D., Pedersen, J. N., Otzen, D. E., Zhang, Y. E. & Brodersen, D. E. (2022). Structural variations between small alarmone hydrolase dimers support different modes of regulation of the stringent response. Journal of Biological Chemistry, 298(7), [102142]. https://doi.org/10.1016/j.jbc.2022.102142

Bale, L. K., Schafer, M. J., Atkinson, E. J., Le Brasseur, N. K., Haak, A. J., Oxvig, C. & Conover, C. A. (2022). Pregnancy-associated plasma protein-A (PAPP-A) is a key component of an interactive cellular mechanism promoting pulmonary fibrosis. Journal of Cellular Physiology, 237(4), 2220-2229. https://doi.org/10.1002/jcp.30687

Bachmaier, S., Giacomelli, G., Calvo-Alvarez, E., Vieira, L. R., Van Den Abbeele, J., Aristodemou, A., Lorentzen, E., Gould, M. K., Brennand, A., Dupuy, J. W., Forné, I., Imhof, A., Bramkamp, M., Salmon, D., Rotureau, B. & Boshart, M. (2022). A multi-adenylate cyclase regulator at the flagellar tip controls African trypanosome transmission. Nature Communications, 13(1), [5445]. https://doi.org/10.1038/s41467-022-33108-z

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Lisbeth Heilesen

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