Find

For students
For PhDs
For employees

Department of Molecular Biology and Genetics

Peer-reviewed articles

Publications from the department

Journal covers made by researchers from our department

Peer-reviewed publications at MBG - 2025

Sort by: Date | Author | Title

Shiraz, M. G., Nielsen, J., Widmann, J., Chung, K. H. K., Davis, T. P., Rasmussen, C., Scavenius, C., Enghild, J. J., Martin-Gallausiaux, C., Singh, Y., Javed, I. & Otzen, D. E. (2025). Young rat microbiota extracts strongly inhibit fibrillation of α-synuclein and protect neuroblastoma cells and zebrafish against α-synuclein toxicity. Molecules and Cells, 48(1), Article 100161. https://doi.org/10.1016/j.mocell.2024.100161

Boonkaew, S., Teodori, L., Vendelbo, M. H., Kjems, J. & Ferapontova, E. E. (2025). Nanobodies' duo facilitates ultrasensitive serum HER-2/neu immunoassays via enhanced avidity interactions. Analytica Chimica Acta, 1335, 343472. Article 343472. https://doi.org/10.1016/j.aca.2024.343472

López Hernández, M., Otzen, D. E. & Pedersen, J. S. (2025). Investigating the interactions between an industrial lipase and anionic (bio)surfactants. Journal of Colloid and Interface Science, 679(B), 294-306. https://doi.org/10.1016/j.jcis.2024.10.060

Yuan, H., Mitchell, C. W., Ferenbach, A. T., Bonati, M. T., Feresin, A., Benke, P. J., Tan, Q. K. G. & van Aalten, D. M. F. (2025). Exploiting O-GlcNAc dyshomeostasis to screen O-GlcNAc transferase intellectual disability variants. Stem Cell Reports, 20(1), 102380. https://doi.org/10.1016/j.stemcr.2024.11.010

Radak, Z. & Rattan, S. I. S. (2025). Exercise, hormesis and ageing: a new section in Biogerontology. Biogerontology, 26(1), 26. Article 26. https://doi.org/10.1007/s10522-024-10170-2

Nybo, T., Gamon, L. F., Fuentes-Lemus, E., Otzen, D. E., Davies, M. J. & Hägglund, P. (2025). Dimethyl labeling of N-terminal amines allows unambiguous identification of protein crosslinks. Free Radical Biology & Medicine, 227, 629-637. https://doi.org/10.1016/j.freeradbiomed.2024.12.002

Sall, K. K., Foldager, L., Delf, C., Christensen, S. J., Agerley, M. N., Havn, K. T. & Pedersen, C. (2025). Control of neonatal diarrhea in piglets with reduced antibiotic use by application of a complementary feed - a randomized controlled farm trial. Veterinary Sciences, 12(1), Article 42. https://doi.org/10.3390/vetsci12010042

Nguyen, M. T. A., Andersen, E. S. & Pothoulakis, G. (2025). Construction of Small Genes with Repetitive Elements Using Oligo Extension and Golden Gate Assembly. Methods in molecular biology (Clifton, N.J.), 2850, 219-227. https://doi.org/10.1007/978-1-0716-4220-7_12

Peer-reviewed publications at MBG - all years

Sort by: Date | Author | Title

Kassen, R. & Bataillon, T. (2006). The distribution of fitness effects among beneficial mutations prior to selection in experimental populations of bacteria, Nature Genetics.

De Mita, S., Santoni, S., Hochu, I., Ronfort, J. & Bataillon, T. (2006). Molecular evolution and positive selection of the symbiotic gene NORK in Medicago truncatula. Journal of Molecular Evolution, 62(2), 234-244.

Søndergaard, C. S., Bonde, J., Dagnæs-Hansen, F., Nielsen, J. M., Zachar, V., Holm, M. S., Hokland, P. & Pedersen, L. (2009). Minimal engraftment of human CD34⁺ cells mobilized from healthy donors in the infarcted heart of athymic nude rats. Stem Cells and Development, 18(6), 845-856.

Glemin, S., Ronfort, J., Vimond, L., Bataillon, T. & Mignot, A. (2006). Marker-based investigation of inbreeding depression in the endangered species Brassica insularis. Iden, 97(4), 304-311.

Christiansen, J. R., Olesen, M. N., Otzen, D. E., Romero-Ramos, M. & Sanchez-Guajardo, V. (2016). α-Synuclein vaccination modulates regulatory T cell activation and microglia in the absence of brain pathology. Journal of Neuroinflammation, 13(1), Article 74. https://doi.org/10.1186/s12974-016-0532-8

Sahin, C., Kjær, L., Christensen, M. S., Nedergaard Pedersen, J., Christiansen, G., Pérez, A.-M. W., Moller, I. M., Enghild, J., Pedersen, J. S., Larsen, K. & Otzen, D. E. (2018). α-synucleins from animal species show low fibrillation propensities and weak oligomer membrane disruption. Biochemistry, 57(34), 5145-5158. https://doi.org/10.1021/acs.biochem.8b00627

Delaidelli, A., Richner, M., Jiang, L., van der Laan, A., Bergholdt Jul Christiansen, I., Ferreira, N., Nyengaard, J. R., Vægter, C. B., Jensen, P. H., Mackenzie, I. R., Sorensen, P. H. & Jan, A. (2021). α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response. Acta Neuropathologica Communications, 9(1), Article 105. https://doi.org/10.1186/s40478-021-01209-3

Alam, P., Bousset, L., Melki, R. & Otzen, D. E. (2019). α-synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities. Journal of Neurochemistry, 150(5), 522-534. https://doi.org/10.1111/jnc.14808

van Diggelen, F., Tepper, A., Petri, M. & Otzen, D. (2017). α-Synuclein Oligomers: A Study in Diversity. Israel Journal of Chemistry, 57(7-8), 699-723. https://doi.org/10.1002/ijch.201600116

Harwood, S. L., Nielsen, N. S., Jensen, K. T., Nielsen, P. K., Thøgersen, I. B. & Enghild, J. J. (2020). α₂-macroglobulin-like protein 1 can conjugate and inhibit proteases through their hydroxyl groups, because of an enhanced reactivity of its thiol ester. Journal of Biological Chemistry, 295(49), 16732-16742. https://doi.org/10.1074/jbc.RA120.015694

Otzen, D., Sehgal, P. & Westh, P. (2009). α-lactalbumin is unfolded by all classes of detergents but with different mechanisms. Journal of Colloid and Interface Science, 329, 273-283.

Doganli, C., Beck, H. C., Ribera, A. B., Oxvig, C. & Lykke-Hartmann, K. (2013). α3Na+/K+-ATPase deficiency causes brain ventricle dilation and abrupt embryonic motility in zebrafish. Journal of Biological Chemistry, 288, 8862-8874. https://doi.org/10.1074/jbc.M112.421529

Stevenson, L., Laursen, E., Cowan, G. J., Bandoh, B., Barfod, L., Cavanagh, D. R., Andersen, G. R. & Hviid, L. (2015). α2-Macroglobulin Can Crosslink Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Molecules and May Facilitate Adhesion of Parasitized Erythrocytes. P L o S Pathogens, 11(7), 1-19. Article e1005022. https://doi.org/10.1371/journal.ppat.1005022

Salvesen, G. & Enghild, J. J. (1991). Zymogen activation specificity and genomic structures of human neutrophil elastase and cathepsin G reveal a new branch of the chymotrypsinogen superfamily of serine proteinases. Biomedica Biochimica Acta, 50(4-6), 665-71.

Sand, A., Kristiansen, M., Pedersen, C. N. S. & Mailund, T. (2013). zipHMMlib: a highly optimised HMM library exploiting repetitions in the input to speed up the forward algorithm. BMC Bioinformatics , 14(339), 339-348. https://doi.org/10.1186/1471-2105-14-339

Lin, J., Bjørk, P. K., Kolte, M. V., Poulsen, E., Dedic, E., Drace, T., Andersen, S. U., Nadzieja, M., Liu, H., Castillo-Michel, H., Escudero, V., González-Guerrero, M., Boesen, T., Pedersen, J. S., Stougaard, J., Andersen, K. R. & Reid, D. (2024). Zinc mediates control of nitrogen fixation via transcription factor filamentation. Nature, 631(8019), 164-169. https://doi.org/10.1038/s41586-024-07607-6

Brodersen, D. E., Nyborg, J. & Kjeldgaard, M. (1999). Zinc-binding site of an S100-protein revealed. Two crystal structures of Ca²⁺-bound human psoriasin (S100A7) in the Zn²⁺-loaded and Zn²⁺-free states. Biochemistry, 38, 1695-1704.

Andersen-Civil, A. I. S., Sawale, R. A. & Vanwalleghem, G. C. (2023). Zebrafish (Danio rerio) as a translational model for neuro-immune interactions in the enteric nervous system in autism spectrum disorders. Brain, Behavior, and Immunity, 112, 254-266. https://doi.org/10.1016/j.bbi.2023.06.001

Doğanli, C., Oxvig, C. & Lykke-Hartmann, K. (2013). Zebrafish as a novel model to assess Na⁺/K⁺-ATPase-related neurological disorders. Neuroscience & Biobehavioral Reviews, 37(10 Part2), 2774–2787. https://doi.org/10.1016/j.neubiorev.2013.09.013

Shiraz, M. G., Nielsen, J., Widmann, J., Chung, K. H. K., Davis, T. P., Rasmussen, C., Scavenius, C., Enghild, J. J., Martin-Gallausiaux, C., Singh, Y., Javed, I. & Otzen, D. E. (2025). Young rat microbiota extracts strongly inhibit fibrillation of α-synuclein and protect neuroblastoma cells and zebrafish against α-synuclein toxicity. Molecules and Cells, 48(1), Article 100161. https://doi.org/10.1016/j.mocell.2024.100161

Gotfryd, K., Boesen, T., Mortensen, J. S., Khelashvili, G., Quick, M., Terry, D. S., Missel, J. W., LeVine, M. V., Gourdon, P., Blanchard, S. C., Javitch, J. A., Weinstein, H., Loland, C. J., Nissen, P. & Gether, U. (2020). X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release. Nature Communications, 11(1), Article 1005. https://doi.org/10.1038/s41467-020-14735-w

Brodersen, D. E., Jenner, L. B., Andersen, G. R. & Nyborg, J. (1999). Xact: A program for construction, automated setup, and bookkeeping of crystallisation experiments. Journal of Applied Crystallography, 32, 1012-1016.

Patro, B. S., Hougaard, R. F., Bohr, V. & Stevnsner, T. V. (2011). WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-IDNA covalent complexes. Journal of Cell Science, 124, 3967-3979. https://doi.org/10.1242/jcs.081372

Patro, B. S., Frøhlich, R., Bohr, V. A. & Stevnsner, T. (2011). WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes. Journal of Cell Science, 124(23), 3967-3979. https://doi.org/10.1242/jcs.081372

Bukowy, Z. K., A. Harrigan, J., A. Ramsden, D., Tudek, B., Bohr, V. & Stevnsner, T. V. (2008). WRN Exonuclease activity is blocked by specific oxidatively induced base lesions positioned in either DNA strand. Nucleic Acids Research, 1-13.

Bergman, J., Pedersen, R., Lundgren, E. J., Lemoine, R. T., Monsarrat, S., Pearce, E. A., Schierup, M. H. & Svenning, J. C. (2023). Worldwide Late Pleistocene and Early Holocene population declines in extant megafauna are associated with Homo sapiens expansion rather than climate change. Nature Communications, 14(1), Article 7679. https://doi.org/10.1038/s41467-023-43426-5

Arendt, M., Rosenberg, R., Foldager, L., Sher, L. & Munk-Jørgensen, P. (2007). Withdrawal symptoms do not predict relapse among subjects treated for cannabis dependence. American Journal on Addictions, 16(6), 461-467.

Jensen, B. N., Wang, Y., Friec, A. L., Nabavi, S. . M. . S., Dong, MD., Seliktar, D. & Chen, M. (2023). Wireless electromagnetic neural stimulation patch with anisotropic guidance. npj Flexible Electronics, 7(1), Article 34. https://doi.org/10.1038/s41528-023-00270-3

Nielsen, S. B., Macchi, F., Raccosta, S., Langkilde, A. E., Giehm, L., Kyrsting, A., Svane, A. S. P., Manno, M., Christiansen, G., Nielsen, N. C., Oddershede, L., Vestergaard, B. & Otzen, D. (2013). Wildtype and A30P Mutant Alpha-Synuclein Form Different Fibril Structures. P L o S One, 8(7), Article e67713. https://doi.org/10.1371/journal.pone.0067713

Trolle, C., Nielsen, M. M., Skakkebæk, A., Lamy, P., Vang, S., Hedegaard, J., Nordentoft, I., Ørntoft, T. F., Pedersen, J. S. & Gravholt, C. H. (2016). Widespread DNA hypomethylation and differential gene expression in Turner syndrome. Scientific Reports, 6, Article 34220. https://doi.org/10.1038/srep34220

Fukai, E., Yoshikawa, M., Shah, N., Sandal, N., Miyao, A., Ono, S., Hirakawa, H., Akyol, T. Y., Umehara, Y., Nonomura, K.-I., Stougaard, J., Hirochika, H., Hayashi, M., Sato, S., Andersen, S. U. & Okazaki, K. (2022). Widespread and transgenerational retrotransposon activation in inter- and intra-species recombinant inbred populations of Lotus japonicus. The Plant Journal, 111(5), 1397-1410. https://doi.org/10.1111/tpj.15896

Jensen, P. L., Dueholm, M. S., Larsen, P., Petersen, S. V., Enghild, J. J., Christiansen, G., Højrup, P., Nielsen, P. H. & Otzen, D. (2009). Widespread abundance of Functional Bacterial Amyloid in Mycolata and other Gram positive Bacteria. Applied and Environmental Microbiology, 75, 4101-4110.

Jordal, P. B., Dueholm, M. S., Larsen, P., Petersen, S. V., Enghild, J. J., Christiansen, G., Højrup, P., Nielsen, P. H. & Otzen, D. E. (2009). Widespread abundance of functional bacterial amyloid in mycolata and other gram-positive bacteria. Applied and Environmental Microbiology, 75(12), 4101-10. https://doi.org/10.1128/AEM.02107-08

Murra, M., Lützen, L., Barut, A., Zbinden, R., Lund, M., Villesen, P. & Nørskov-Lauritsen, N. (2018). Whole-genome sequencing of aggregatibacter species isolated from human clinical specimens and description of Aggregatibacter kilianii sp. Nov. Journal of Clinical Microbiology, 56(7), Article UNSP e00053-18. https://doi.org/10.1128/JCM.00053-18

Kim, S. W., Lee, H., Song, D. Y., Lee, G. H., Ji, J., Park, J. W., Han, J. H., Lee, J. W., Byun, H. J., Son, J. H., Kim, Y. R., Lee, Y., Kim, J., Jung, A., Lee, J., Kim, E., Kim, S. H., Lee, J. H., Satterstrom, F. K. ... An, J. Y. (2024). Whole genome sequencing analysis identifies sex differences of familial pattern contributing to phenotypic diversity in autism. Genome Medicine, 16(1), 114. Article 114. https://doi.org/10.1186/s13073-024-01385-6

Branca, A., Paape, T. D., Zhou, P., Briskine, R., Farmer, A. D., Mudge, J., Bharti, A. K., Woodward, J. E., May, G. D., Gentzbittel, L., Ben, C., Denny, R., Sadowsky, M. J., Ronfort, J., Bataillon, T., Young, N. D. & Tiffin, P. (2011). Whole-genome nucleotide diversity, recombination, and linkage disequilibrium in the model legume Medicago truncatula. Proceedings of the National Academy of Sciences (PNAS), 108(42), 864-870. https://doi.org/10.1073/pnas.1104032108

Mailund, T., Besenbacher, S. & Schierup, M. H. (2006). Whole genome association mapping by incompatibilities and local perfect phylogenies. B M C Bioinformatics, 7(454). https://doi.org/10.1186/1471-2105-7-454

Nordentoft, I. K., Lamy, P., Birkenkamp-Demtröder, K., Vang, S., Reinert, T., Hedegaard, J., Thorsen, K., Fristrup, N., Borre, M., Andersen, L. D., Pedersen, J. S. & Ørntoft, T. F. (2013). Whole genome and transcriptome analysis reveals novel genomic alterations in bladder cancer. Poster session presented at American Association for Cancer Research, Washington, DC, United States.

Stukenbrock, E., Jørgensen, F., Zala, M., Hansen, T. T., McDonald, B. A. & Schierup, M. H. (2010). Whole-genome and chromosome evolution associated with host adaptation and speciation of the wheat pathogen Mycosphaerella graminicola. P L o S Genetics, 23(6).

Jarvis, E. D., Mirarab, S., Aberer, A. J., Li, B., Houde, P., Li, C., Ho, S. Y. W., Faircloth, B. C., Nabholz, B., Howard, J. T., Suh, A., Weber, C. C., da Fonseca, R. R., Li, J., Zhang, F., Li, H., Zhou, L., Narula, N., Liu, L. ... Zhang, G. (2014). Whole-genome analyses resolve early branches in the tree of life of modern birds. Science, 346(6215), 1320-31. https://doi.org/10.1126/science.1253451

Lescai, F., Als, T. D., Li, Q., Nyegaard, M., Andorsdottir, G., Biskopstø, M., Hedemand, A., Fiorentino, A., O'Brien, N. L., Jarram, A., Liang, T. J., Grove, J., Pallesen, J., Eickhardt, E., Mattheisen, M., Bolund, L., Demontis, D., Wang, A. G., McQuillin, A. ... Børglum, A. D. (2017). Whole-exome sequencing of individuals from an isolated population implicates rare risk variants in bipolar disorder. Translational Psychiatry, 7(2), e1034. Article 3. https://doi.org/10.1038/tp.2017.3

Munk-Jørgensen, P., Allgulander, C., Dahl, A., Foldager, L., Holm, M., Rasmussen, I., Virta, A., Huuhtanen, M. & Wittchen, H.-U. (2006). Who is recognised for generalized anxiety disorder in general practice? A survey in Denmark, Finland, Norway and Sweden. Psychiatric Services, 57(10), 1738-1744.

Ehlers, B. & Schierup, M. H. (2008). When gametophytic self-incompatibility meets gynodioecy. Genetics Research, 90(1), 27-35. https://doi.org/10.1017/S0016672307009007

Madsen, J. K., Kaspersen, J. D., Andersen, K. K., Pedersen, J. S. & Otzen, D. E. (2016). When Enzymes and Green Surfactants Meet. Biophysical Journal, 110(3), 211A. https://doi.org/10.1016/j.bpj.2015.11.1171

O'Brien, T. R., Hartmann, R. & Prokunina-Olsson, L. (2019). What makes the hepatitis C virus evolve? eLife, 8, Article e50148. https://doi.org/10.7554/eLife.50148

Møller, I. M. (2016). What is hot in plant mitochondria? Physiologia Plantarum, 157(3), 256-263. https://doi.org/10.1111/ppl.12456

Bailey, S. F., Blanquart, F., Bataillon, T. & Kassen, R. (2017). What drives parallel evolution? How population size and mutational variation contribute to repeated evolution. BioEssays, 39(1), 1-9. https://doi.org/10.1002/bies.201600176

Chen, J., Bataillon, T., Glémin, S. & Lascoux, M. (2022). What does the distribution of fitness effects of new mutations reflect? Insights from plants. New Phytologist, 233(4), 1613-1619. https://doi.org/10.1111/nph.17826

Olshansky, S. J. & Rattan, S. (2005). What determines longevity: metabolic rate or stability? Discovery Medicine, 5, 359-362.

Ahn, B., Stevnsner, T. & Bohr, V. A. (2015). Werner syndrome: Association of premature aging and cancer predisposition. In E. P. Gelmann, C. L. Sawyers & F. J. Rauscher, III (Eds.), Molecular Oncology: Causes of Cancer and Targets for Treatment (pp. 423-433). Cambridge University Press. https://doi.org/10.1017/CBO9781139046947.036

Displaying results 1 to 50 out of 4940

1

Search for publications

Revised 02.12.2024

-

Lisbeth Heilesen