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Jan J. Enghild

Research project: Proteome analysis and protein characterization

The laboratory seeks to describe the "structure–activity–function" algorithm of proteins. Our research is located at the interface between other structure analyses methods (NMR and X-ray crystallography) and we use a combination of protein chemistry, proteomics, enzymology, and recombinant DNA techniques.


We are interested in extracellular matrix (ECM) homeostasis and the identification and characterization of post-translational modifications. Available structural and functional information concerning ECM proteins is limited due to the inherent insolubility.

Granular corneal dystrophy, Type I

A superposition of the crystal structures of bovine TAFI (green) and porcine carboxypeptidase B (purple). Read more.

Protein Characterization

Our research is located at the interface between other structure analyses methods (NMR and X-ray crystallography) and we use a combination of protein chemistry, proteomics, enzymology, and recombinant DNA techniques.

  • Bikunin Proteins
  • Extracellular superoxide dismutase (EC-SOD)
  • Matrix metalloproteinase (MMP)
  • Novel proteolytic enzymes
  • Pigment epithelium-derived factor (PEDF)
  • Thrombin Activatable Fibrinolysis inhibitor (TAFI)
  • Transforming growth factor beta induced protein (TGFBIP) and cornea dystrophies
  • Transglutaminase