Aarhus University Seal / Aarhus Universitets segl

RNA regulation is crucial for embryonic stem cell differentiatior


A functional link between nuclear RNA decay and transcriptional control by the Polycomb Repressive Complex 2. In the absence of PAXT-mediated RNA decay, nuclear pA+ transcripts are stabilised. Excess RNA binds and out-titrates PRC2 from chromatin, and the interaction between complex subunits is disrupted. Normal PRC2-repressed loci show decreased H3K27me3 levels and correlates with increased an increase in transcription. Figure: Will Garland/AU

2019.11.15 | Research

RNA regulation is crucial for embryonic stem cell differentiation

Nuclear RNA levels are kept in check by RNA decay factors. Now, researchers at Aarhus and Copenhagen Universities show that an excess of RNA in the nucleus can have negative effects on a crucial regulator of stem cell differentiation.

Bjørn Panyella Pedersen. Photo: AU Photo

2019.11.13 | People

Bjørn Panyella Pedersen selected as EMBO Young Investigator

MBG Group Leader Bjørn Panyella Pedersen is one of 27 researchers that have been selected to join the Young Investigators Programme of the European Molecular Biology Organization (EMBO) in 2019. For the coming four years, he will join this prestigious network of young scientists.

Assistant Professor Lasse Sommer Kristensen, Department of Molecular Biology and Genetics, Aarhus University. Photo: Lundbeckfonden

2019.11.06 | Grant

Researcher will improve diagnoses for cancer

More knowledge about so-called circular RNA could improve the ability to make more accurate diagnoses and predict how the individual patient will respond to certain types of cancer drugs. Lasse Sommer Kristensen from the Department of Molecular Biology and Genetics, AU, receives DKK 10 million from the Lundbeck Foundation for the project.