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Ion and lipid transporters specialize for their niche



News

Professor Poul Nissen awarded Anders Jahre's major medical award in 2021 for his research in membrane proteins. Photo: Lisbeth Heilesen

2021.06.10 | Awards

Professor Poul Nissen awarded the Anders Jahre medical prize 2021

One of Scandinavia’s most prestigious research honours, the Anders Jahre Medical Prize, has been conferred on Professor Poul Nissen of Aarhus University. The prize has been awarded in recognition of Professor Nissen’s groundbreaking research on the structure and function of membrane proteins. His work has advanced our understanding of a variety of…

Binding site I of SERCA is not conserved in LMCA1. Alignment between LMCA1 G4 E2-BeF3- (red) and SERCA E2-AlF4- (pdb: 3b9r) (dark grey). Relevant Ca2+-coordinating residues are shown as sticks. The structures are aligned by the residues shown as sticks. SERCA Ca2+ binding site I and II are indicated. Figure: Sara Basse Hansen.

2021.06.09 | Research

Ion and lipid transporters specialize for their niche

Cell viability require that a variety of functions at the cell membrane are maintained properly. P-type ATPases translocate substrates across the membrane, and they have evolved into different types taking care of specific substrates within a diverse range. Now, key structural aspects have been described on how two different types of P-type…

An artistic rendering of RNA polymerase folding RNA origami scaffolds with two proteins. At the top right a finished scaffolding with proteins marked with the colors yellow and cyan. Figure: Cody Geary
Overview of some of the RNA origami structures designed in the current study compared with a bacterial ribosome (grey). RNA origami structures are coloured by the elements they consist of: 180 degree interactions (purple), 120 degree interactions (dark green), tetra loops (yellow) and dovetail seams (dark blue). Central structure scaffold aptamers (green and orange) and fluorescent proteins. Figure: Cody Geary and Ebbe S. Andersen.
Design and characterisation of RNA origami structures. RNA drawings, atomic models and sequences are designed on the computer. A DNA template is synthesised and transcribed and then folded by an RNA polymerase. The RNA structure is characterised by microscopy methods. Figure: Cody Geary

2021.06.01 | Research

Bigger and better RNA scaffolds for organising proteins

Researchers from Aarhus University and Caltech have developed a method to build much larger, though still nanosize, RNA scaffolds than previously thought possible using RNA origami. The method is based on new software that has been made available online so other researchers can use it to develop biosensors, nanorobots and medicine – including…

Events

Mon 21 Jun
13:00-14:30 | Seminar room Mol X lab, building 1120
Master's thesis defence: Regulation of Base Excision Repair Through Cyclic AMP Response Element-Binding Protein
Stine Eg Asmussen. Supervisor: Tinna Stevnsner. Co-supervisor: Knud Erik Larsen
Tue 22 Jun
10:00-11:30 | Seminar room in Mol X Lab, building 1120
Master's thesis defence: The effects of CDK5- and PKCgamma-mediated PTM Phosphorylation on the Interaction Dynamics and Enzymatic Activity of Endonuclease VIII-Like Protein 2
Andreas Philip Andersen. Supervisor: Tinna Stevnsner
Tue 22 Jun
13:00-14:30 | Seminar room in Mol X Lab, building 1120
Master's thesis defence: Investigating the role of phosphorylation of Nei Like DNA Glycosylase 2 (NEIL2) in vitro
Mine Tilken. Supervisor: Tinna Stevnsner