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The cryoEM facility EMBION receives USD 2.1 million from the Novo Nordisk Foundation for large equipment



News

Poul Nissen (right) and his colleagues will establish an Infrastructure for Cryo-Electron Tomography (ICE-T) which will be embedded in the Danish National Cryo-EM Facility – EMBION – where cryo-CLEM and high-end cryo-TEMs are available. From the left: Thomas Boesen and Gregers Rom Andersen. Photo: Lisbeth Heilesen
Titan Krios2 during installation at the EMBION facility will be crucial for the workflow in ICE-T. Photo: Thomas Boesen

2020.10.09 | Grant

The cryoEM facility EMBION receives USD 2.1 million from the Novo Nordisk Foundation for large equipment

With the grant from the Novo Nordisk Foundation, main applicant Poul Nissen and colleagues from the Department of Molecular Biology and Genetics and iNANO as well as partners at the Department of Biomedicine and the Department of Engineering will be able to establish an infrastructure for Cryo-Electron Tomography (ICE-T), which will also be made…

Pseudo-coloured electron micrograph depicting nanoparticles circulating in the bloodstream along with red blood cells (red) and those sequestered in endothelial cells lining the blood vessel (yellow). (Figure: Yuya Hayashi).
Fluorescently labelled 70 nm SiO2 nanoparticles were injected into the bloodstream of 3 days old transgenic zebrafish embryos and live-imaged at 3 min after the injection. The insets show schematics for the two conditions tested: control nanoparticles with a corona of endogenous proteins (orange) and nanoparticles with a pre-formed corona of fetal bovine serum (FBS) proteins (blue) and additional endogenous proteins. Control nanoparticles are rapidly captured by macrophages, while the nanoparticles with a non-self biological identity are effectively sequestered by scavenger endothelial cells. (Image: Yuya Hayashi. Adapted from Mohammad-Beigi et al. (2020) ACS Nano. Copyright 2020 American Chemical Society)
Hossein Mohammad-Beigi from iNANO (left) and Yuya Hayashi from MBG work together to tackle long-standing questions in bionanoscience using a zebrafish model (Photo: Hoda Eskandari)

2020.09.30 | Research

Zebrafish embryos help prove what happens to nanoparticles in the blood

What happens to the nanoparticles when they are injected into the bloodstream, for example, to destroy solid tumours? With new results published in ACS Nano, researchers from Aarhus University are now ready to tackle such a challenging question using zebrafish embryos as a new study model in nanomedicine and nanotoxicology.

A Danish research team shows in Nature Communications how they have developed a new approach for faster, though more in-depth studies of corona proteins, which affect the functional role of nanoparticles. The image schematizes a nanoparticle covered by corona proteins. (Image: <em>Nature Com.</em> 11, Article no. 4535 (2020))

2020.09.25 | Research

AU researchers contribute to understanding corona proteins on nanoparticles

The properties of nanoparticles are widely acknowledged and they are an important tool in pharmaceutical applications, among others. However, there is a need for deeper understanding of the protein layers accumulating on their surface, as these protein layers affect the functional role of the nanoparticles. AU researchers have developed a method…

A Danish research team describes in an article in <em>Nature Communications</em> how a well-described circular RNA molecule, which was thought to be carcinogenic, is not found in the cancer cells after all.

2020.09.21 | Research

Well-known RNA molecule is not present in cancer cells after all

A so-called circular RNA molecule, which is thought to be carcinogenic, is not present in cancer cells after all. A Danish research team has published the new results in Nature Communications.

Events

Fri 23 Oct
13:15-15:15 | The PhD defence will be held online
PhD defence: Structural insight into sterol uptake – an essential part of cellular biology
Mikael Winkler
Mon 26 Oct
15:00-16:30 | William Scharff auditorium (1253-317)
Master's thesis exam: An Investigation of the Effects of PiT2 (Slc20a2)-Knockout on the Differentiation Potential of Murine Bone Marrow Mesenchymal Stem Cells
Eden Klepper. Supervisor: Lene Pedersen
Fri 30 Oct
13:00-15:00 | 1131-623, C.F. Møllers Allé 3
Kvalifikationseksamen: Structural dynamics of NMDA receptors
Oscar Gabriel Sevillano Quispe

PhD defences

Mikael Winkler

2020.10.23 | PhD defense

Mikael Becher Lykkegaard Winkler: Structural insight into sterol uptake – an essential part of cellular biology

PhD defence, Friday 23 October 2020. Mikael Becher Lykkegaard Winkler.

I-Ju Lo

2020.10.19 | PhD defense

I-Ju Lo: Functional genomic insights of circRNAs in Alzheimer’s disease

PhD defence, Monday 19 October 2020, I-Ju Lo.

Britt Kidmose Ardal

2020.10.19 | PhD defense

Britt Kidmose Ardal: Are your genes under control?

PhD defence, Monday 19 October 2020. Britt Kidmose Ardal.