Development, health, and ageing in multicellular organisms rely on tightly coordinated communication between cells. This intercellular signaling is essential for ensuring that cells behave appropriately according to their position and function within the body, thereby maintaining homeostasis. Disruptions in these pathways can lead to malformations, improper cell development, diseases such as cancer, or premature cell death.
At the same time, diet plays a significant role in regulating these biological processes. Foods contain a wide array of bioactive compounds that act as signaling molecules, influencing growth, development, health, and disease. Our research focuses on identifying, isolating, and characterizing these compounds, as well as investigating their function in physiological systems.
We also explore how genomic instability and DNA repair mechanisms - particularly within mitochondria - contribute to the ageing process in mammals. The accumulation of DNA damage is believed to be a key driver of ageing, although many of the underlying mechanisms remain poorly understood.
By integrating knowledge of cellular communication, dietary bioactives, and genomic stability, we aim to gain a deeper understanding of the complex interactions that shape organismal health and longevity.
