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Institut for Molekylærbiologi og Genetik

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Tidsskriftsforsider lavet af forskere fra MBG

Peer-review'ede publikationer ved MBG

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Harwood, S. L., Nielsen, N. S., Jensen, K. T., Nielsen, P. K., Thøgersen, I. & Enghild, J. J. (2020). α₂-Macroglobulin-like protein 1 can conjugate and inhibitproteases through their hydroxyl groups, because of anenhanced reactivity of its thiol ester. Journal of Biological Chemistry, 295(49), 16732-16742. https://doi.org/10.1074/jbc.RA120.015694

Doganli, C., Beck, H. C., Ribera, A. B., Oxvig, C. & Lykke-Hartmann, K. (2013). α3Na+/K+-ATPase deficiency causes brain ventricle dilation and abrupt embryonic motility in zebrafish. Journal of Biological Chemistry, 288, 8862-8874. https://doi.org/10.1074/jbc.M112.421529

Stevenson, L., Laursen, E., Cowan, G. J., Bandoh, B., Barfod, L., Cavanagh, D. R., Andersen, G. R. & Hviid, L. (2015). α2-Macroglobulin Can Crosslink Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Molecules and May Facilitate Adhesion of Parasitized Erythrocytes. P L o S Pathogens, 11(7), 1-19. [e1005022]. https://doi.org/10.1371/journal.ppat.1005022

Sahin, C., Kjær, L., Christensen, M. S., Nedergaard Pedersen, J., Christiansen, G., Pérez, A-M. W., Moller, I. M., Enghild, J., Pedersen, J. S., Larsen, K. & Otzen, D. E. (2018). α-synucleins from animal species show low fibrillation propensities and weak oligomer membrane disruption. Biochemistry, 57(34), 5145-5158. https://doi.org/10.1021/acs.biochem.8b00627

Alam, P., Bousset, L., Melki, R. & Otzen, D. E. (2019). α-synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities. Journal of Neurochemistry, 150(5), 522-534. https://doi.org/10.1111/jnc.14808

Otzen, D., Sehgal, P. & Westh, P. (2009). α-lactalbumin is unfolded by all classes of detergents but with different mechanisms. Journal of Colloid and Interface Science, 329, 273-283.

Christiansen, J. R., Olesen, M. N., Otzen, D. E., Romero-Ramos, M. & Sanchez-Guajardo, V. (2016). α-Synuclein vaccination modulates regulatory T cell activation and microglia in the absence of brain pathology. Journal of Neuroinflammation, 13, [74]. https://doi.org/10.1186/s12974-016-0532-8

van Diggelen, F., Tepper, A., Petri, M. & Otzen, D. (2017). α-Synuclein Oligomers: A Study in Diversity. Israel Journal of Chemistry, 57(7-8), 699-723. https://doi.org/10.1002/ijch.201600116

Søndergaard, C. S., Bonde, J., Dagnæs-Hansen, F., Nielsen, J. M., Zachar, V., Holm, M. S., Hokland, P. & Pedersen, L. (2009). Minimal engraftment of human CD34⁺ cells mobilized from healthy donors in the infarcted heart of athymic nude rats. Stem Cells and Development, 18(6), 845-856.

Jepsen, M., Beerens, N., Krüger, A. C., Kjems, J. & Birkedal, V. (2012). tRNA Annealing onto the HIV-1 Genome Studied by FRET Spectroscopy and Microscopy. Biophysical Journal, 102(3, Supplement 1), 278a . https://doi.org/10.1016/j.bpj.2011.11.1533

Andersen, M. Ø., Nygaard, J. V., Burns, J. S., Raarup, M. K., Nyengaard, J. R., Bünger, C., Besenbacher, F., Howard, K. A., Kassem, M. & Kjems, J. (2010). siRNA nanoparticle functionalization of nanostructured scaffolds enables controlled multilineage differentiation of stem cells. Molecular Therapy, 18(11), 2018-2027. https://doi.org/10.1038/mt.2010.166

Wang, H., Andersen, K. K., Sehgal, P., Hagedorn, J., Westh, P., Borch, K. & Otzen, D. E. (2013). pH regulation of the kinetic stability of the lipase from Thermomyces lanuginosus. Biochemistry, 52(1), 264-276. https://doi.org/10.1021/bi301258e

Hartmann, R., Olsen, H. S., Widder, S., Jørgensen, R. & Justesen, J. (1998). p59OASL, a 2’-5’ oligoadenylate synthetase like protein: a novel human gene related to the 2’-5’ oligoadenylate synthetase family. Nucleic Acids Research, 26, 4121-4127.

Laska, M. J., Vogel, U. B., Jensen, U. B. & Nexø, B. A. (2010). p53 and PPP1R13L (alias iASPP or RAI) form a feedback loop to regulate genotoxic stress responses. BBA General Subjects, 1800(12), 1231-40. https://doi.org/10.1016/j.bbagen.2010.09.002

Song, Y. J. C., Lundvig, D. M. S., Huang, Y., Gai, W. P., Blumbergs, P. C., Højrup, P., Otzen, D., Halliday, G. M. & Jensen, P. H. (2007). p25a Relocalizes in Oligodendroglia from Myelin to Cytoplasmic Inclusions in Multiple System Atrophy. Am. J. Path., (171), 1291-1303.

Pedersen, H. S., Løvendahl, P., Larsen, K. E., Madsen, L. B. & Callesen, H. (2014). mtDNA copy number in oocytes of different sizes from individual pre- and post-pubertal pigs. Reproduction, Fertility and Development, 27(1), 181-182. [(abst 181)]. https://doi.org/10.1071/RDv27n1Ab181

Holt, D. B., Gupta, V., Meyer, D., Abel, N. B., Andersen, S. U., Stougaard, J. & Markmann, K. (2015). micro RNA 172 (miR172) signals epidermal infection and is expressed in cells primed for bacterial invasion in Lotus japonicus roots and nodules. New Phytologist, 208(1), 241-256. https://doi.org/10.1111/nph.13445

Hansen, T. B., Venø, M. T., Kjems, J. & Damgaard, C. K. (2014). miRdentify: high stringency miRNA predictor identifies several novel animal miRNAs. Nucleic Acids Research, 42(16), 1-11. [e124]. https://doi.org/10.1093/nar/gku598

Hansen, T. B., Wiklund, E. D., Bramsen, J. B., Villadsen, S. B., Statham, A. L., Clark, S. J. & Kjems, J. (2011). miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA. E M B O Journal, 30(21), 4414-4422. https://doi.org/10.1038/emboj.2011.359

Hua, Y., Duan, S., Murmann, A. E., Larsen, N., Kjems, J., Lund, A. H. & Peter, M. E. (2011). miRConnect:Identifying effector genes of miRNAs and miRNA families in cancer cells. P L o S One, 6(10), e26521. https://doi.org/10.1371/journal.pone.0026521

Hua, Y., Larsen, N., Kalyana-Sundaram, S., Kjems, J., Chinnaiyan, A. M. & Peter, M. E. (2013). miRConnect 2.0: identification of oncogenic, antagonistic miRNA families in three human cancers. B M C Genomics, 14(179), 1-18. https://doi.org/10.1186/1471-2164-14-179

Menbari, M. N., Rahimi, K., Ahmadi, A., Mohammadi-Yeganeh, S., Elyasi, A., Darvishi, N., Hosseini, V. & Abdi, M. (2020). miR-483-3p suppresses the proliferation and progression of human triple negative breast cancer cells by targeting the HDAC8>oncogene. Journal of Cellular Physiology, 235(3), 2631-2642. https://doi.org/10.1002/jcp.29167

Ostenfeld, M. S., Bramsen, J. B., Lamy, P., Villadsen, S. B., Fristrup, N., Ulhøi, B. P., Borre, M., Kjems, J., Dyrskjøt, L. & Ørntoft, T. F. (2009). miR-145 induces caspase-dependent and -independent cell death in urothelial cancer cell lines with targeting of an expression signature present in Ta bladder tumors. Oncogene. https://doi.org/10.1038/onc.2009.395

Ostenfeld, M. S., Bramsen, J. B., Lamy, P., Villadsen, S. B., Fristrup, N., Dalsgaard Sørensen, K., Ulhøi, B. P., Borre, M., Kjems, J., Andersen, L. D. & Ørntoft, T. F. (2010). miR-145 induces caspase-dependent and -independent cell death in urothelial cancer cell lines with targeting of an expression signature present in Ta bladder tumors. Oncogene, 29(7), 1073. https://doi.org/10.1038/onc.2009.395

Jia, J-J., Lahr, R. M., Solgaard, M. T., Moraes, B. J., Pointet, R., Yang, A-D., Celucci, G., Graber, T. E., Hoang, H-D., Niklaus, M. R., Pena, I. A., Hollensen, A. K., Smith, E. M., Chaker-Margot, M., Anton, L., Dajadian, C., Livingstone, M., Hearnden, J., Wang, X-D. ... Fonseca, B. D. (2021). mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1. Nucleic Acids Research, 49(6), 3461-3489. https://doi.org/10.1093/nar/gkaa1239

Mühlemann, O. & Jensen, T. H. (2012). mRNP quality control goes regulatory. Trends in Genetics, 28(2), 70-77. https://doi.org/10.1016/j.tig.2011.11.001

iNEXT Consortium (2018). iNEXT: a European facility network to stimulate translational structural biology. FEBS Letters, 592(12), 1909-1917. https://doi.org/10.1002/1873-3468.13062

Damgaard, C. K., Tange, T. Ø. & Kjems, J. (2002). hnRNP A1 controls HIV-1 mRNA splicing through cooperative binding to intron and exon splicing silencers in the context of a conserved secondary structure. RNA, 8.

Winding, A., Bang-Andreasen, T., Hansen, L. H., Panitz, F., Krogh, P. H., Krause-Jensen, D., Stæhr, P., Nicolaisen, M., Hendriksen, N. B., Sapkota, R., Santos, S. & Andersen, L. W. (2019). eDNA in environmental monitoring. Aarhus Universitet, DCE – Nationalt Center for Miljø og Energi ©. DCE Technical reports Nr. 133 https://dce2.au.dk/pub/TR133.pdf

Hollensen, A. K., Thomsen, H. S., Lloret-Llinares, M., Kamstrup, A. B., Jensen, J. M., Luckmann, M., Birkmose, N., Palmfeldt, J., Jensen, T. H., Hansen, T. B. & Damgaard, C. K. (2020). circZNF827 nucleates a transcription inhibitory complex to balance neuronal differentiation. eLife, 9, [e58478]. https://doi.org/10.7554/eLife.58478

Luecke, S., Holleufer, A., Christensen, M. H., Jønsson, K. L., Boni, G. A., Sørensen, L. K., Johannsen, M., Jakobsen, M. R., Hartmann, R. & Paludan, S. R. (2017). cGAS is activated by DNA in a length-dependent manner. E M B O Reports, 18(10), 1707–1715. https://doi.org/10.15252/embr.201744017

Scaal, M., Füchtbauer, E-M. & Brand-Saberi, B. (2001). c-Dermol expression is upregulated by BMP signal. Brain Structure and Function (Print Edition), 203, 1-7.

Nielsen, S. B., Franzmann, M., Basaiawmoit, R. V., Wimmer, R., Mikkelsen, J. D. & Otzen, D. E. (2010). beta-Sheet aggregation of kisspeptin-10 is stimulated by heparin but inhibited by amphiphiles. Biopolymers, 93(8), 678-89. https://doi.org/10.1002/bip.21434

Salvesen, G. & Enghild, J. J. (1993). alpha-Macroglobulins: detection and characterization. Methods in Enzymology, 223, 121-41.

Falkenberg, C., Allhorn, M., Thøgersen, I. B., Valnickova, Z., Pizzo, S. V., Salvesen, G., Akerström, B. & Enghild, J. J. (1995). alpha 1-Microglobulin destroys the proteinase inhibitory activity of alpha 1-inhibitor-3 by complex formation. Journal of Biological Chemistry, 270(9), 4478-83.

Salvesen, G. & Enghild, J. J. (1991). Zymogen activation specificity and genomic structures of human neutrophil elastase and cathepsin G reveal a new branch of the chymotrypsinogen superfamily of serine proteinases. Biomedica Biochimica Acta, 50(4-6), 665-71.

Brodersen, D. E., Nyborg, J. & Kjeldgaard, M. (1999). Zinc-binding site of an S100-protein revealed. Two crystal structures of Ca²⁺-bound human psoriasin (S100A7) in the Zn²⁺-loaded and Zn²⁺-free states. Biochemistry, 38, 1695-1704.

Doğanli, C., Oxvig, C. & Lykke-Hartmann, K. (2013). Zebrafish as a novel model to assess Na⁺/K⁺-ATPase-related neurological disorders. Neuroscience & Biobehavioral Reviews, 37(10 Part2), 2774–2787. https://doi.org/10.1016/j.neubiorev.2013.09.013

Brodersen, D. E., Jenner, L. B., Andersen, G. R. & Nyborg, J. (1999). Xact: A program for construction, automated setup, and bookkeeping of crystallisation experiments. Journal of Applied Crystallography, 32, 1012-1016.

Gotfryd, K., Boesen, T., Mortensen, J. S., Khelashvili, G., Quick, M., Terry, D. S., Missel, J. W., LeVine, M. V., Gourdon, P., Blanchard, S. C., Javitch, J. A., Weinstein, H., Loland, C. J., Nissen, P. & Gether, U. (2020). X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release. Nature Communications, 11(1), [1005]. https://doi.org/10.1038/s41467-020-14735-w

Nielsen, S. B., Macchi, F., Raccosta, S., Langkilde, A. E., Giehm, L., Kyrsting, A., Svane, A. S. P., Manno, M., Christiansen, G., Nielsen, N. C., Oddershede, L., Vestergaard, B. & Otzen, D. (2013). Wildtype and A30P Mutant Alpha-Synuclein Form Different Fibril Structures. P L o S One, 8(7), [e67713]. https://doi.org/10.1371/journal.pone.0067713

Jordal, P. B., Dueholm, M. S., Larsen, P., Petersen, S. V., Enghild, J. J., Christiansen, G., Højrup, P., Nielsen, P. H. & Otzen, D. E. (2009). Widespread abundance of functional bacterial amyloid in mycolata and other gram-positive bacteria. Applied and Environmental Microbiology, 75(12), 4101-10. https://doi.org/10.1128/AEM.02107-08

Jensen, P. L., Dueholm, M. S., Larsen, P., Petersen, S. V., Enghild, J. J., Christiansen, G., Højrup, P., Nielsen, P. H. & Otzen, D. (2009). Widespread abundance of Functional Bacterial Amyloid in Mycolata and other Gram positive Bacteria. Applied and Environmental Microbiology, 75, 4101-4110.

Madsen, J. K., Kaspersen, J. D., Andersen, K. K., Pedersen, J. S. & Otzen, D. E. (2016). When Enzymes and Green Surfactants Meet. Biophysical Journal, 110(3), 211A. https://doi.org/10.1016/j.bpj.2015.11.1171

Borg, S., Brinch-Pedersen, H., Tauris, B., Madsen, L. H., Shirvanehdeh, B. D., Noeparvar, S. & Holm, P. B. (2012). Wheat ferritins: Improving the iron content of the wheat grain. Journal of Cereal Science, 56(2), 204-213. https://doi.org/10.1016/j.jcs.2012.03.005

O'Brien, T. R., Hartmann, R. & Prokunina-Olsson, L. (2019). What makes the hepatitis C virus evolve? eLife, 8, [e50148]. https://doi.org/10.7554/eLife.50148

Møller, I. M. (2016). What is hot in plant mitochondria? Physiologia Plantarum, 157(3), 256-263. https://doi.org/10.1111/ppl.12456

Olshansky, S. J. & Rattan, S. (2005). What determines longevity: metabolic rate or stability? Discovery Medicine, 5, 359-362.

Habeck, M. & Poulsen, H. (2021). What FXYDs fix. The Journal of general physiology, 153(6). https://doi.org/10.1085/jgp.202012845

Ahn, B., Stevnsner, T. & Bohr, V. A. (2015). Werner syndrome: Association of premature aging and cancer predisposition. I E. P. Gelmann, C. L. Sawyers & F. J. Rauscher, III (red.), Molecular Oncology: Causes of Cancer and Targets for Treatment (s. 423-433). Cambridge University Press. https://doi.org/10.1017/CBO9781139046947.036

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Lisbeth Heilesen