I am Associate Professor at Aarhus University's Department of Biomedicine, specializing in muscle physiology and stem cell research. Moreover, I am affiliated with Steno Diabetes Center Aarhus, where my research group is also situated. With a background in human physiology, I have developed a keen interest in understanding how muscle function is affected during various conditions, including aging and metabolic diseases. My research primarily focuses on the role of skeletal muscle stem cells and fibro-adipogenic progenitors in muscle degeneration and regeneration. My group combines basic and translational strategies to explore these cellular dynamics, aiming to uncover novel therapeutic approaches for muscle-related diseases.
My research aims to elucidate the role of the human skeletal muscle microenvironment during age- and disease-related muscle degeneration and wasting. My group investigates strategies to rejuvenate this microenvironment to restore muscle mass and function. A significant aspect of my research involves understanding whether intrinsic or environmental factors underlie the dysfunction of muscle stem cell populations during aging and diseases characterized by muscle degeneration. Utilizing both basic and translational research approaches, his work seeks to identify novel therapeutic targets for muscle-related diseases.
My expertise lies in muscle physiology, cell biology, and cellular interactions, with a particular emphasis on skeletal muscle adaptation, tissue and cellular transformations, metabolism, and signaling. I investigate the interactions between muscle stem cells, mesenchymal-derived cells, and immune cells in maintaining muscle homeostasis, regeneration, and their roles in disease states. Some work also delves into the effects of exercise and pharmacological strategies on health, including their impact on conditions like heart failure, cancer cachexia and other conditions accelerating muscle wasting and degeneration.
