Peer-reviewed articles

Publications from the department

Journal covers made by researchers from our department

Peer-reviewed publications at MBG - 2025

Kofod Petersen, A., Forgie, A. H., Villesen, P. & Staun Larsen, L. (2025). 3D dental similarity quantification in forensic odontology identification. Forensic Science International, 370, Article https://doi.org/10.1016/j.forsciint.2025.112462. https://doi.org/10.1016/j.forsciint.2025.112462

Kriebisch, C. M. E., Bantysh, O., Baranda Pellejero, L., Belluati, A., Bertosin, E., Dai, K., de Roy, M., Fu, H., Galvanetto, N., Gibbs, J. M., Gomez, S. S., Granatelli, G., Griffo, A., Guix, M., Gurdap, C. O., Harth-Kitzerow, J., Haugerud, I. S., Häfner, G., Jaiswal, P. ... Boekhoven, J. (2025). A roadmap toward the synthesis of life. Chem, 11(3), Article 102399. https://doi.org/10.1016/j.chempr.2024.102399

Theologidis, V., Ferreira, S. A., Jensen, N. M., Gomes Moreira, D., Ahlgreen, O. A., Hansen, M. W., Rosenberg, E. D., Richner, M., Faress, I., Gram, H., Jensen, P. H., Borghammer, P., Nyengaard, J. R., Romero-Ramos, M., Vægter, C. B., van de Berg, W. D. J., Van Den Berge, N. & Jan, A. (2025). Bradykinesia and postural instability in a model of prodromal synucleinopathy with α-synuclein aggregation initiated in the gigantocellular nuclei. Acta Neuropathologica Communications, 13(1), 32. Article 32. https://doi.org/10.1186/s40478-025-01948-7

Bendtsen, M. K., Nowak, J. S., Paiva, P., López Hernández, M., Ferreira, P., Pedersen, J. S., Bekker, N. S., Viezzi, E., Bisiak, F., Brodersen, D. E., Pedersen, L. H., Zervas, A., Fernandes, P. A., Ramos, M. J., Stougaard, P., Thøgersen, M. S. & Otzen, D. E. (2025). Cold-Active Starch-Degrading Enzymes from a Cold and Alkaline Greenland Environment: Role of Ca 2+ Ions and Conformational Dynamics in Psychrophilicity. Biomolecules, 15(3). https://doi.org/10.3390/biom15030415

Digel, L., Justesen, M. L., Madsen, N. S., Fransaert, N., Wouters, K., Bonné, R., Plum-Jensen, L. E., Marshall, I. P. G., Jensen, P. B., Nicolas-Asselineau, L., Drace, T., Bøggild, A., Hansen, J. L., Schramm, A., Bøjesen, E. D., Nielsen, L. P., Manca, J. V. & Boesen, T. (2025). Comparison of cable bacteria genera reveals details of their conduction machinery. EMBO Reports, Article 13699. Advance online publication. https://doi.org/10.1038/s44319-025-00387-8

Prip, F., Lamy, P., Lindskrog, S. V., Strandgaard, T., Nordentoft, I., Birkenkamp-Demtröder, K., Birkbak, N. J., Kristjánsdóttir, N., Kjær, A., Andreasen, T. G., Ahrenfeldt, J., Pedersen, J. S., Rasmussen, A. M., Hermann, G. G., Mogensen, K., Petersen, A. C., Hartmann, A., Grimm, M. O., Horstmann, M. ... UROMOL Consortium (2025). Comprehensive genomic characterization of early-stage bladder cancer. Nature Genetics, 57(1), 115-125. Article 2301. https://doi.org/10.1038/s41588-024-02030-z

Nguyen, M. T. A., Andersen, E. S. & Pothoulakis, G. (2025). Construction of Small Genes with Repetitive Elements Using Oligo Extension and Golden Gate Assembly. In D. Schindler (Ed.), Golden Gate Cloning (pp. 219-227). Humana Press. https://doi.org/10.1007/978-1-0716-4220-7_12

Sall, K. K., Foldager, L., Delf, C., Christensen, S. J., Agerley, M. N., Havn, K. T. & Pedersen, C. (2025). Control of neonatal diarrhea in piglets with reduced antibiotic use by application of a complementary feed - a randomized controlled farm trial. Veterinary Sciences, 12(1), Article 42. https://doi.org/10.3390/vetsci12010042

Rashidi, A., Füchtbauer, E. M., Vahabzadeh, Z., Soleimani, F., Rahimi, K., Nikkhoo, B., Fakhari, S., Erfan, M. B. K., Azarnezhad, A., Pooladi, A., Soheili, F. & Fathi, F. (2025). CRISPR/Cas9-mediated knockout of DYRK1B in triple-negative breast cancer cells: implications for cell proliferation, apoptosis, and therapeutic sensitivity. Biochemical Engineering Journal, 213, Article 109553. https://doi.org/10.1016/j.bej.2024.109553

Kjær, M. B., Jørgensen, A. G., Fjelstrup, S., Dupont, D. M., Bus, C., Eriksen, P. L., Thomsen, K. L., Risikesan, J., Nielsen, S., Wernberg, C. W., Lauridsen, M. M., Bugianesi, E., Rosso, C., Grønbæk, H. & Kjems, J. (2025). Diagnosis and Staging of Metabolic Dysfunction-Associated Steatotic Liver Disease Using Biomarker-Directed Aptamer Panels. Biomolecules, 15(2), Article 255. https://doi.org/10.3390/biom15020255

Nybo, T., Gamon, L. F., Fuentes-Lemus, E., Otzen, D. E., Davies, M. J. & Hägglund, P. (2025). Dimethyl labeling of N-terminal amines allows unambiguous identification of protein crosslinks. Free Radical Biology & Medicine, 227, 629-637. https://doi.org/10.1016/j.freeradbiomed.2024.12.002

Gadegaard, I. S. E., Madsen, C. M., Johansen, P. M. & Rasmussen, J. T. (2025). Distribution, activity, and storage of xanthine oxidase in bovine milk fractions. International Dairy Journal, 160, Article 106091. https://doi.org/10.1016/j.idairyj.2024.106091

Bøtkjær, J. A., Poulsen, L. L. C., Noer, P. R., Grøndahl, M. L., Englund, A. L. M., Franks, S., Hardy, K., Oxvig, C. & Andersen, C. Y. (2025). Dynamics of IGF Signaling During the Ovulatory Peak in Women Undergoing Ovarian Stimulation. The Journal of clinical endocrinology and metabolism, 110(1), e160-e167. https://doi.org/10.1210/clinem/dgae132

Rasmussen, C. L. M., Frederiksen, S. F., Heegaard, C. W., Thomsen, M. S., Hede, E., Laczek, B., Körbelin, J., Wüstner, D., Thomsen, L. B., Schwaninger, M., Jensen, O. N., Moos, T. & Burkhart, A. (2025). Endothelial and neuronal engagement by AAV-BR1 gene therapy alleviates neurological symptoms and lipid deposition in a mouse model of Niemann-Pick type C2. Fluids and Barriers of the CNS, 22(1), Article 13. https://doi.org/10.1186/s12987-025-00621-4

Lassen, J. K. & Villesen, P. (2025). End-To-End Deep Learning Explains Antimicrobial Resistance in Peak-Picking-Free MALDI-MS Data. Analytical Chemistry, 97(5), 2795-2800. https://doi.org/10.1021/acs.analchem.4c05113

Charmouh, A. P., Porsborg, P. S., Hansen, L. T., Besenbacher, S., Boeg Winge, S., Almstrup, K., Hobolth, A., Bataillon, T. & Schierup, M. H. (2025). Estimating Gene Conversion Tract Length and Rate From PacBio HiFi Data. Molecular Biology and Evolution, 42(2), Article msaf019. https://doi.org/10.1093/molbev/msaf019

Radak, Z. & Rattan, S. I. S. (2025). Exercise, hormesis and ageing: a new section in Biogerontology. Biogerontology, 26(1), 26. Article 26. https://doi.org/10.1007/s10522-024-10170-2

Yuan, H., Mitchell, C. W., Ferenbach, A. T., Bonati, M. T., Feresin, A., Benke, P. J., Tan, Q. K. G. & van Aalten, D. M. F. (2025). Exploiting O-GlcNAc dyshomeostasis to screen O-GlcNAc transferase intellectual disability variants. Stem Cell Reports, 20(1), 102380. Article 102380. https://doi.org/10.1016/j.stemcr.2024.11.010

Khachadourian, V., Arildskov, E. S., Grove, J., O'Reilly, P. F., Buxbaum, J. D., Reichenberg, A., Sandin, S., Croen, L. A., Schendel, D., Hansen, S. N. & Janecka, M. (2025). Familial confounding in the associations between maternal health and autism. Nature Medicine, 31(3), 996-1007. https://doi.org/10.1038/s41591-024-03479-5

Mundy, J., Hall, A. S. M., Agerbo, E., Albiñana, C., Steinbach, J., Vilhjálmsson, B. J., Østergaard, S. D. & Musliner, K. L. (2025). Genetic Confounding of the Association Between Age at First Hormonal Contraception and Depression. Acta Psychiatrica Scandinavica, 151(4), 529-536. https://doi.org/10.1111/acps.13774

Cabrejas-Olalla, A., Jørgensen, F. G., Cheng, J. Y., Kjærgaard, P. C., Schierup, M. H., Mailund, T. & Athanasiadis, G. (2025). Genetic predictions of eye and hair colour in the Danish population. Forensic Science International: Genetics, 78, Article 103267. https://doi.org/10.1016/j.fsigen.2025.103267

PGC TS Working Group & 23andMe Research Team (2025). Genome-Wide Association Study Meta-Analysis of 9619 Cases With Tic Disorders. Biological Psychiatry, 97(7), 743-752. https://doi.org/10.1016/j.biopsych.2024.07.025

23andMe Research Team (2025). Genomics yields biological and phenotypic insights into bipolar disorder. Nature, Article 2417. https://doi.org/10.1038/s41586-024-08468-9

Qin, Q., Wei, P., Usman, S., Ahamefule, C. S., Jin, C., Wang, B., Yan, K., van Aalten, D. M. F. & Fang, W. (2025). Gfa1 (glutamine fructose-6-phosphate aminotransferase) is essential for Aspergillus fumigatus growth and virulence. BMC Biology, 23(1), Article 80. https://doi.org/10.1186/s12915-025-02184-0

Li, Z., Xue, Y., Duan, Y., Yuan, W., Chen, C., Shi, S., Su, X. C., Kisiswa, L., Fan, J. S. & Lin, Z. (2025). Heterotypic interactions among members of the death domain superfamily with implications for p75^NTR-mediated co-signaling. International Journal of Biological Macromolecules, 304(Part 1), Article 140791. https://doi.org/10.1016/j.ijbiomac.2025.140791

Andersen, H. H., Andersen, M. K., Bossow, K. A., Vestergaard, A. L., Bor, P. & Larsen, A. (2025). High-dose vitamin D supplementation in pregnancy ameliorates obesity-induced increase in maternal IL-1β level without affecting obesity-induced increase in IL-6 and MCP-1. The Journal of Steroid Biochemistry and Molecular Biology, 250. https://doi.org/10.1016/j.jsbmb.2025.106742

Li, Q., Marietou, A., Andersen, F. F., Hosek, J., Scavenius, C., Zhang, J. & Schwab, C. (2025). In vitro investigations on the impact of fermented dairy constituents on fecal microbiota composition and fermentation activity. Microbiology Spectrum, 13(3), e0219324. https://doi.org/10.1128/spectrum.02193-24

Wang, J., Kidmose, R. T., Boegholm, N., Zacharia, N. K., Thomsen, M. B., Christensen, A., Malik, T., Lechtreck, K. & Lorentzen, E. (2025). Integrative in silico and biochemical analyses demonstrate direct Arl3-mediated ODA16 release from the intraflagellar transport machinery. Journal of Biological Chemistry, 301(3), Article 108237. https://doi.org/10.1016/j.jbc.2025.108237

Otzen, D. E., Peña-Díaz, S., Widmann, J., Daugberg, A. O. H., Zhang, Z., Jiang, Y., Mittal, C., Dueholm, M. K. D., Louros, N., Wang, H. & Javed, I. (2025). Interactions between pathological and functional amyloid: A match made in Heaven or Hell? Molecular Aspects of Medicine, 103, 101351. Article 101351. Advance online publication. https://doi.org/10.1016/j.mam.2025.101351

Olsen, W. P., Larsen, A.-K. K., Christensen, J. L., Malle, M. G. & Otzen, D. E. (2025). Investigating strategies for creating cross-linked amyloid fibril networks through branching of amyloid growth. Colloids and surfaces. B, Biointerfaces, 251, 114617. Article 114617. Advance online publication. https://doi.org/10.1016/j.colsurfb.2025.114617

López Hernández, M., Otzen, D. E. & Pedersen, J. S. (2025). Investigating the interactions between an industrial lipase and anionic (bio)surfactants. Journal of Colloid and Interface Science, 679(B), 294-306. https://doi.org/10.1016/j.jcis.2024.10.060

Buhl, E. H., Christensen, B., Pedersen, F. H. & S⊘rensen, E. S. (2025). Milk osteopontin has high iron-binding capacity and facilitates iron absorption in intestinal cells. Journal of Dairy Science, 108(1), 90-100. https://doi.org/10.3168/jds.2024-25305

Christensen, B., Krüger, T. F., Hjorth, T. P., Buhl, E. H. & Sørensen, E. S. (2025). Milk osteopontin mediates zinc uptake in intestinal cells in the presence of phytic acid. International Dairy Journal, 161, Article 106113. https://doi.org/10.1016/j.idairyj.2024.106113

Boonkaew, S., Teodori, L., Vendelbo, M. H., Kjems, J. & Ferapontova, E. E. (2025). Nanobodies' duo facilitates ultrasensitive serum HER-2/neu immunoassays via enhanced avidity interactions. Analytica Chimica Acta, 1335, Article 343472. https://doi.org/10.1016/j.aca.2024.343472

Subrahmaniam, H. J., Pico, X., Bataillon, T., Salomonsen, C. L., Glasius, M. & Ehlers, B. (2025). Natural variation in root exudate composition in the genetically structured Arabidopsis thaliana in the Iberian Peninsula. New Phytologist, 245(4), 1437-1449. https://doi.org/10.1111/nph.20314

Bryzek, D., Gasiorek, A., Kowalczyk, D., Santocki, M., Ciaston, I., Dobosz, E., Kolaczkowska, E., Kjøge, K., Kantyka, T., Lech, M., Potempa, B., Enghild, J. J., Potempa, J. & Koziel, J. (2025). Non-classical neutrophil extracellular traps induced by PAR2-signaling proteases. Cell Death & Disease, 16(1), 109. Article 109. https://doi.org/10.1038/s41419-025-07428-z

Schlosser, A., Pilecki, B., Allen, C., Benest, A. V., Lynch, A. P., Hua, J., Ved, N., Blackley, Z., Andersen, T. L., Hennig, D., Graversen, J. H., Möller, S., Skallerup, S., Ormhøj, M., Lange, C., Agostini, H. T., Grauslund, J., Heegaard, S., Dacheva, I. ... Sorensen, G. L. (2025). Pharmacological blocking of microfibrillar-associated protein 4 reduces retinal neoangiogenesis and vascular leakage. Molecular Therapy, 33(3), 1048-1072. https://doi.org/10.1016/j.ymthe.2025.01.038

APEX consortium & Mortensen, P. B. (2025). Polygenic scores for autism are associated with reduced neurite density in adults and children from the general population. Molecular Psychiatry, Article 2301. Advance online publication. https://doi.org/10.1038/s41380-025-02927-z

Martín-Rivada, Á., Martos-Moreno, G., Guerra-Cantera, S., Campillo-Calatayud, A., Oxvig, C., Frystyk, J., Chowen, J. A., Barrios, V. & Argente, J. (2025). Prepubertal Children With Obesity Have High Free IGF-1 Levels and Accelerated Growth Despite Reduced Pappalysin Levels. Journal of Clinical Endocrinology and Metabolism, 110(3), e622-e629. https://doi.org/10.1210/clinem/dgae288

Golan, N., Parizat, A., Tabachnikov, O., Barnea, E., Olsen, W. P., Otzen, D. E. & Landau, M. (2025). Resilience and Charge-Dependent Fibrillation of functional amyloid: Interactions of Pseudomonas Biofilm-Associated FapB and FapC Amyloids. The Journal of Biological Chemistry, 301(2), Article 108096. https://doi.org/10.1016/j.jbc.2024.108096

Nowak, J. S., Olesen, S., Tian, P., Bærentsen, R. L., Brodersen, D. E. & Otzen, D. E. (2025). Role of electrostatics in cold adaptation: A comparative study of eury- and stenopsychrophilic triose phosphate isomerase. B B A - Proteins and Proteomics, Article 141072. Advance online publication. https://doi.org/10.1016/j.bbapap.2025.141072

Hollingshead, S., McVicker, G., Nielsen, M. R., Zhang, Y., Pilla, G., Jones, R. A., Thomas, J. C., Johansen, S. E. H., Exley, R. M., Brodersen, D. E. & Tang, C. M. (2025). Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system. mBio, 16(2), e0261624. https://doi.org/10.1128/mbio.02616-24

van den Berg, J. & Zeller, P. (2025). Shining a light on cell biology of the nucleus with single-cell sequencing. Current Opinion in Cell Biology, 93, Article 102468. https://doi.org/10.1016/j.ceb.2025.102468

Fraifeld, V. & Rattan, S. (2025). Stem cells in ageing and longevity: a new section in Biogerontology. Biogerontology, 26, Article 69. https://doi.org/10.1007/s10522-025-10217-y

Nel, L., Thaysen, K., Jamecna, D., Olesen, E., Langer, J., Frain, K. M., Szomek, M., Höglinger, D., Wüstner, D. & Pedersen, B. P. (2025). Structural and biochemical analysis of ligand binding in yeast Niemann–Pick type C1–related protein. Life Science Alliance, 8(1), Article e202402990. https://doi.org/10.26508/lsa.202402990

Rotilio, L., Bayer, T., Meinert, H., Teixeira, L. M. C., Johansen, M. B., Sommerfeldt, A., Petersen, A. R., Sandahl, A., Keller, M. B., Holck, J., Paiva, P., Otzen, D. E., Bornscheuer, U. T., Wei, R., Fernandes, P. A., Ramos, M. J., Westh, P. & Morth, J. P. (2025). Structural and Functional Characterization of an Amidase Targeting a Polyurethane for Sustainable Recycling. Angewandte Chemie International Edition, 64(7), Article e202419535. https://doi.org/10.1002/anie.202419535

Thorsen, T. S., Kulkarni, Y., Sykes, D. A., Bøggild, A., Drace, T., Hompluem, P., Iliopoulos-Tsoutsouvas, C., Nikas, S. P., Daver, H., Makriyannis, A., Nissen, P., Gajhede, M., Veprintsev, D. B., Boesen, T., Kastrup, J. S. & Gloriam, D. E. (2025). Structural basis of THC analog activity at the Cannabinoid 1 receptor. Nature Communications, 16(1), Article 486. https://doi.org/10.1038/s41467-024-55808-4

Basse Hansen, S., Flygaard, R. K., Kjaergaard, M. & Nissen, P. (2025). Structure of the [Ca]E2P intermediate of Ca²⁺-ATPase 1 from Listeria monocytogenes. EMBO Reports, Article eadd9742. Advance online publication. https://doi.org/10.1038/s44319-025-00392-x

Singh, P., Kadam, N. Y., Panigrahi, R., Mehrotra, A., Upadhayay, K., Dey, M., Tyagi, A., Aquib, M., Nielsen, J., Kleijwegt, G., Singh, P., Sharma, A., Rao, A., Otzen, D. E., Kumar, A. & Sharma, D. (2025). Sulfamerazine as a Potential Modulator against α-Synuclein Aggregation and Associated Toxicity. ACS Chemical Neuroscience, 16(5), 880-894. https://doi.org/10.1021/acschemneuro.4c00803

McLain, A., Kowalczyk, A., Baran-Rachwalska, P., Sutera, F. M., Robertson, L. J., Nielsen, N. S., Enghild, J. J., Cobice, D., Bonelli, F., Barbaro, V., Ferrari, S., Patterson, B., Moore, L., Marshall, J., Nesbit, M. A. & Moore, T. (2025). TGFBI R124H mutant allele silencing in granular corneal dystrophy type 2 using topical siRNA delivery. Journal of Controlled Release, 382, Article 113681. https://doi.org/10.1016/j.jconrel.2025.113681

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