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Peer-reviewed publications at MBG - 2025

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Kefalopoulou, S., Rullens, P. M. J., de Luca, K. L., de Vries, S. S., Korthout, T., van Oudenaarden, A., Zeller, P. & Kind, J. (2025). Retrospective and multifactorial single-cell profiling reveals sequential chromatin reorganization during X inactivation. Nature Cell Biology, 27(7), 1186-1198. https://doi.org/10.1038/s41556-025-01687-w
Gobet, A., Moissonnier, L., Zarkadas, E., Magnard, S., Bettler, E., Martin, J., Terreux, R., Schoehn, G., Orelle, C., Jault, J. M., Falson, P. & Chaptal, V. (2025). Rhodamine6G and Hœchst33342 narrow BmrA conformational spectrum for a more efficient use of ATP. Nature Communications, 16(1), Article 1745. https://doi.org/10.1038/s41467-025-56849-z
Stenberg, K., Korhonen, S., Seemab, U., Dupont, D. M., Kjems, J., Honkakoski, P. & Subrizi, A. (2025). Selection of locally administered ocular tissue-targeting RNA aptamers using in vivo SELEX. European Journal of Pharmaceutical Sciences, 212, Article 107217. https://doi.org/10.1016/j.ejps.2025.107217
Baindoor, S., Gibriel, H. A. Y., Kool, L., Su, J., Demaegd, K. C., Venø, M. T., Van Den Berg, L. H., Kjems, J., Van Es, M. A. & Prehn, J. H. M. (2025). Serum small non-coding RNA define molecular subtypes in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. Advance online publication. https://doi.org/10.1080/21678421.2025.2574690
Hollingshead, S., McVicker, G., Nielsen, M. R., Zhang, Y., Pilla, G., Jones, R. A., Thomas, J. C., Johansen, S. E. H., Exley, R. M., Brodersen, D. E. & Tang, C. M. (2025). Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system. mBio, 16(2), e0261624. https://doi.org/10.1128/mbio.02616-24
Blotenburg, M., Suurenbroek, L., Bax, D., de Visser, J., Bhardwaj, V., Braccioli, L., de Wit, E., van Boxtel, A., Marks, H. & Zeller, P. (2025). Stem cell culture conditions affect in vitro differentiation potential and mouse gastruloid formation. PLoS One, 20(3), Article e0317309. https://doi.org/10.1371/journal.pone.0317309
Nel, L., Thaysen, K., Jamecna, D., Olesen, E., Langer, J., Frain, K. M., Szomek, M., Höglinger, D., Wüstner, D. & Pedersen, B. P. (2025). Structural and biochemical analysis of ligand binding in yeast Niemann–Pick type C1–related protein. Life Science Alliance, 8(1), Article e202402990. https://doi.org/10.26508/lsa.202402990
Rotilio, L., Bayer, T., Meinert, H., Teixeira, L. M. C., Johansen, M. B., Sommerfeldt, A., Petersen, A. R., Sandahl, A., Keller, M. B., Holck, J., Paiva, P., Otzen, D. E., Bornscheuer, U. T., Wei, R., Fernandes, P. A., Ramos, M. J., Westh, P. & Morth, J. P. (2025). Structural and Functional Characterization of an Amidase Targeting a Polyurethane for Sustainable Recycling. Angewandte Chemie International Edition, 64(7), Article e202419535. https://doi.org/10.1002/anie.202419535
Dubiez, E., Garland, W., Finderup Brask, M., Boeri Erba, E., Heick Jensen, T., Kadlec, J. & Cusack, S. (2025). Structural basis for the synergistic assembly of the snRNA export complex. Nature Structural and Molecular Biology, 32(8), 1555-1566. https://doi.org/10.1038/s41594-025-01595-5
Thorsen, T. S., Kulkarni, Y., Sykes, D. A., Bøggild, A., Drace, T., Hompluem, P., Iliopoulos-Tsoutsouvas, C., Nikas, S. P., Daver, H., Makriyannis, A., Nissen, P., Gajhede, M., Veprintsev, D. B., Boesen, T., Kastrup, J. S. & Gloriam, D. E. (2025). Structural basis of THC analog activity at the Cannabinoid 1 receptor. Nature Communications, 16(1), Article 486. https://doi.org/10.1038/s41467-024-55808-4
Silale, A., Madej, M., Mikruta, K., Frey, A. M., Hart, A. J., Baslé, A., Scavenius, C., Enghild, J. J., Trost, M., Hirt, R. P. & van den Berg, B. (2025). Structure of a distinct β-barrel assembly machinery complex in the Bacteroidota. Nature Microbiology, 10(11), 2845-2859. https://doi.org/10.1038/s41564-025-02132-2
Singh, P., Kadam, N. Y., Panigrahi, R., Mehrotra, A., Upadhayay, K., Dey, M., Tyagi, A., Aquib, M., Nielsen, J., Kleijwegt, G., Singh, P., Sharma, A., Rao, A., Otzen, D. E., Kumar, A. & Sharma, D. (2025). Sulfamerazine as a Potential Modulator against α-Synuclein Aggregation and Associated Toxicity. ACS Chemical Neuroscience, 16(5), 880-894. https://doi.org/10.1021/acschemneuro.4c00803
McLain, A., Kowalczyk, A., Baran-Rachwalska, P., Sutera, F. M., Robertson, L. J., Nielsen, N. S., Enghild, J. J., Cobice, D., Bonelli, F., Barbaro, V., Ferrari, S., Patterson, B., Moore, L., Marshall, J., Nesbit, M. A. & Moore, T. (2025). TGFBI R124H mutant allele silencing in granular corneal dystrophy type 2 using topical siRNA delivery. Journal of Controlled Release, 382, Article 113681. https://doi.org/10.1016/j.jconrel.2025.113681
Malham, M., Vestergaard, M. V., Bataillon, T., Villesen, P., Dempfle, A., Bang, C., Engsbro, A. L., Jakobsen, C., Franke, A., Wewer, V., Thingholm, L. B. & Petersen, A. M. (2025). The Composition of the Fecal and Mucosa-adherent Microbiota Varies Based on Age and Disease Activity in Ulcerative Colitis. Inflammatory Bowel Diseases, 31(2), 501-513. https://doi.org/10.1093/ibd/izae179
Car, J., Ong, Q. C., Erlikh Fox, T., Leightley, D., Kemp, S. J., Švab, I., Tsoi, K. K. F., Sam, A. H., Kent, F. M., Hertelendy, A. J., Longhurst, C. A., Powell, J., Hamdy, H., Nguyen, H. V. Q., Aoun Bahous, S., Wang, M., Baumgartner, M., Mahendradhata, Y., Popovic, N. ... Digital Health Systems Collaborative (2025). The Digital Health Competencies in Medical Education Framework: An International Consensus Statement Based on a Delphi Study. JAMA network open, 8(1), Article e2453131. https://doi.org/10.1001/jamanetworkopen.2024.53131
Wang, X., Nursyifa, C., Aninta, S. G., Garcia-Erill, G., Bertola, L. D., Khan, A., Kuja, J., Hanghøj, K., Meisner, J., Bøggild, T., Bradshaw, C. J. A., Al-Chaer, A., Persada, A. P., Priyono, D. S., Tribudi, Y. A., Sudrajad, P., Gaina, C. D., Jiang, Y., Lenstra, J. A. ... Heller, R. (2025). The genetic diversity of Indonesian cattle has been shaped by multiple introductions and adaptive introgression. Nature Communications, 16(1), Article 8192. https://doi.org/10.1038/s41467-025-62692-z
Conover, C. A. & Oxvig, C. (2025). The IGF System and Aging. Endocrine Reviews, 46(2), 214-223. https://doi.org/10.1210/endrev/bnae029
Marzookian, K., Aliakbari, F., Hourfar, H., Sabouni, F., Otzen, D. E. & Morshedi, D. (2025). The neuroprotective effect of human umbilical cord MSCs-derived secretome against α-synuclein aggregates on the blood-brain barrier. International Journal of Biological Macromolecules, 304(Part 1), Article 140387. https://doi.org/10.1016/j.ijbiomac.2025.140387
Segur-Bailach, E., Mateu-Bosch, A., Bofill-De Ros, X., Parés, M., da Silva Buttkus, P., Rathkolb, B., Gailus-Durner, V., Hrabě de Angelis, M., Moeini, P., Gonzalez-Aseguinolaza, G., Tort, F., Ribes, A., van Karnebeek, C. D. M., García-Villoria, J. & Fillat, C. (2025). Therapeutic AASS inhibition by AAV-miRNA rescues glutaric aciduria type I severe phenotype in mice. Molecular Therapy, 33(10), 4820-4833. https://doi.org/10.1016/j.ymthe.2025.07.022
Poulsen, E. T., Nielsen, N. S. & Enghild, J. J. (2025). The role of the extracellular matrix in TGFBI-related corneal dystrophy development. In E. K. Kim & R. D. Stulting (Eds.), TGFBI-related Corneal Dystrophies: Clinical Findings, Cell Biology, and Genetics (pp. 77-94). Springer. https://doi.org/10.1007/978-981-96-0131-8_9
Shah, A., Zhang, X., Snee, M., Lockhart-Cairns, M. P., Levy, C. W., Jowitt, T. A., Birchenough, H. L., Dean, L., Collins, R., Dodd, R. J., Roberts, A. R. E., Enghild, J. J., Mantovani, A., Fontana, J., Baldock, C., Inforzato, A., Richter, R. P. & Day, A. J. (2025). The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix. Matrix biology : journal of the International Society for Matrix Biology, 136, 52-68. https://doi.org/10.1016/j.matbio.2025.01.002
O’Leary, E., Jiang, Y., Kristensen, L. S., Hansen, T. B. & Kjems, J. (2025). The therapeutic potential of circular RNAs. Nature Reviews Genetics, 26(4), 230-244. Article 2629. https://doi.org/10.1038/s41576-024-00806-x
McLain, A., Saffie-Siebert, S. R., Nielsen, N. S., Patterson, B., Scavenius, C., Enghild, J. J., Marshall, J., Baran-Rachwalska, P., Welsh, M., Sutera, F. M., Moore, L., Willoughby, C., Nesbit, M. A. & Moore, T. (2025). Topical mutant allele-specific siRNA delivery for treatment of Meesmann epithelial corneal dystrophy and elucidation of disease biomarkers. Journal of Controlled Release, 388, Article 114315. https://doi.org/10.1016/j.jconrel.2025.114315
Paiva, P., Teixeira, L. M. C., Ferreira, P., Otzen, D. E., Fernandes, P. A. & Ramos, M. J. (2025). Transforming Computational Power into Environmental Solutions: HPC-driven Research on Urethanase-mediated Plastic Degradation. Procedia Computer Science, 267, 207-217. https://doi.org/10.1016/j.procs.2025.08.247

Peer-reviewed publications at MBG - all years

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Zhang, C., Reid, K., Schierup, M. H., Wang, H., Candolin, U. & Merilä, J. (2025). Rate of de novo mutations in the three-spined stickleback. Heredity, 134(7), 387-395. https://doi.org/10.1038/s41437-025-00767-9
Riedelbauch, S., Masser, S., Fasching, S., Lin, S. Y., Salgania, H. K., Aarup, M., Ebert, A., Jeske, M., Levine, M. T., Stelzl, U. & Andersen, P. (2025). Recurrent innovation of protein-protein interactions in the Drosophila piRNA pathway. EMBO Journal, Article 98. Advance online publication. https://doi.org/10.1038/s44318-025-00439-8
Golan, N., Parizat, A., Tabachnikov, O., Barnea, E., Olsen, W. P., Otzen, D. E. & Landau, M. (2025). Resilience and Charge-Dependent Fibrillation of functional amyloid: Interactions of Pseudomonas Biofilm-Associated FapB and FapC Amyloids. The Journal of Biological Chemistry, 301(2), Article 108096. https://doi.org/10.1016/j.jbc.2024.108096
Kefalopoulou, S., Rullens, P. M. J., de Luca, K. L., de Vries, S. S., Korthout, T., van Oudenaarden, A., Zeller, P. & Kind, J. (2025). Retrospective and multifactorial single-cell profiling reveals sequential chromatin reorganization during X inactivation. Nature Cell Biology, 27(7), 1186-1198. https://doi.org/10.1038/s41556-025-01687-w
Gobet, A., Moissonnier, L., Zarkadas, E., Magnard, S., Bettler, E., Martin, J., Terreux, R., Schoehn, G., Orelle, C., Jault, J. M., Falson, P. & Chaptal, V. (2025). Rhodamine6G and Hœchst33342 narrow BmrA conformational spectrum for a more efficient use of ATP. Nature Communications, 16(1), Article 1745. https://doi.org/10.1038/s41467-025-56849-z
Stenberg, K., Korhonen, S., Seemab, U., Dupont, D. M., Kjems, J., Honkakoski, P. & Subrizi, A. (2025). Selection of locally administered ocular tissue-targeting RNA aptamers using in vivo SELEX. European Journal of Pharmaceutical Sciences, 212, Article 107217. https://doi.org/10.1016/j.ejps.2025.107217
Baindoor, S., Gibriel, H. A. Y., Kool, L., Su, J., Demaegd, K. C., Venø, M. T., Van Den Berg, L. H., Kjems, J., Van Es, M. A. & Prehn, J. H. M. (2025). Serum small non-coding RNA define molecular subtypes in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. Advance online publication. https://doi.org/10.1080/21678421.2025.2574690
Hollingshead, S., McVicker, G., Nielsen, M. R., Zhang, Y., Pilla, G., Jones, R. A., Thomas, J. C., Johansen, S. E. H., Exley, R. M., Brodersen, D. E. & Tang, C. M. (2025). Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system. mBio, 16(2), e0261624. https://doi.org/10.1128/mbio.02616-24
Blotenburg, M., Suurenbroek, L., Bax, D., de Visser, J., Bhardwaj, V., Braccioli, L., de Wit, E., van Boxtel, A., Marks, H. & Zeller, P. (2025). Stem cell culture conditions affect in vitro differentiation potential and mouse gastruloid formation. PLoS One, 20(3), Article e0317309. https://doi.org/10.1371/journal.pone.0317309
Nel, L., Thaysen, K., Jamecna, D., Olesen, E., Langer, J., Frain, K. M., Szomek, M., Höglinger, D., Wüstner, D. & Pedersen, B. P. (2025). Structural and biochemical analysis of ligand binding in yeast Niemann–Pick type C1–related protein. Life Science Alliance, 8(1), Article e202402990. https://doi.org/10.26508/lsa.202402990
Rotilio, L., Bayer, T., Meinert, H., Teixeira, L. M. C., Johansen, M. B., Sommerfeldt, A., Petersen, A. R., Sandahl, A., Keller, M. B., Holck, J., Paiva, P., Otzen, D. E., Bornscheuer, U. T., Wei, R., Fernandes, P. A., Ramos, M. J., Westh, P. & Morth, J. P. (2025). Structural and Functional Characterization of an Amidase Targeting a Polyurethane for Sustainable Recycling. Angewandte Chemie International Edition, 64(7), Article e202419535. https://doi.org/10.1002/anie.202419535
Dubiez, E., Garland, W., Finderup Brask, M., Boeri Erba, E., Heick Jensen, T., Kadlec, J. & Cusack, S. (2025). Structural basis for the synergistic assembly of the snRNA export complex. Nature Structural and Molecular Biology, 32(8), 1555-1566. https://doi.org/10.1038/s41594-025-01595-5
Thorsen, T. S., Kulkarni, Y., Sykes, D. A., Bøggild, A., Drace, T., Hompluem, P., Iliopoulos-Tsoutsouvas, C., Nikas, S. P., Daver, H., Makriyannis, A., Nissen, P., Gajhede, M., Veprintsev, D. B., Boesen, T., Kastrup, J. S. & Gloriam, D. E. (2025). Structural basis of THC analog activity at the Cannabinoid 1 receptor. Nature Communications, 16(1), Article 486. https://doi.org/10.1038/s41467-024-55808-4
Silale, A., Madej, M., Mikruta, K., Frey, A. M., Hart, A. J., Baslé, A., Scavenius, C., Enghild, J. J., Trost, M., Hirt, R. P. & van den Berg, B. (2025). Structure of a distinct β-barrel assembly machinery complex in the Bacteroidota. Nature Microbiology, 10(11), 2845-2859. https://doi.org/10.1038/s41564-025-02132-2
Singh, P., Kadam, N. Y., Panigrahi, R., Mehrotra, A., Upadhayay, K., Dey, M., Tyagi, A., Aquib, M., Nielsen, J., Kleijwegt, G., Singh, P., Sharma, A., Rao, A., Otzen, D. E., Kumar, A. & Sharma, D. (2025). Sulfamerazine as a Potential Modulator against α-Synuclein Aggregation and Associated Toxicity. ACS Chemical Neuroscience, 16(5), 880-894. https://doi.org/10.1021/acschemneuro.4c00803
McLain, A., Kowalczyk, A., Baran-Rachwalska, P., Sutera, F. M., Robertson, L. J., Nielsen, N. S., Enghild, J. J., Cobice, D., Bonelli, F., Barbaro, V., Ferrari, S., Patterson, B., Moore, L., Marshall, J., Nesbit, M. A. & Moore, T. (2025). TGFBI R124H mutant allele silencing in granular corneal dystrophy type 2 using topical siRNA delivery. Journal of Controlled Release, 382, Article 113681. https://doi.org/10.1016/j.jconrel.2025.113681
Malham, M., Vestergaard, M. V., Bataillon, T., Villesen, P., Dempfle, A., Bang, C., Engsbro, A. L., Jakobsen, C., Franke, A., Wewer, V., Thingholm, L. B. & Petersen, A. M. (2025). The Composition of the Fecal and Mucosa-adherent Microbiota Varies Based on Age and Disease Activity in Ulcerative Colitis. Inflammatory Bowel Diseases, 31(2), 501-513. https://doi.org/10.1093/ibd/izae179
Car, J., Ong, Q. C., Erlikh Fox, T., Leightley, D., Kemp, S. J., Švab, I., Tsoi, K. K. F., Sam, A. H., Kent, F. M., Hertelendy, A. J., Longhurst, C. A., Powell, J., Hamdy, H., Nguyen, H. V. Q., Aoun Bahous, S., Wang, M., Baumgartner, M., Mahendradhata, Y., Popovic, N. ... Digital Health Systems Collaborative (2025). The Digital Health Competencies in Medical Education Framework: An International Consensus Statement Based on a Delphi Study. JAMA network open, 8(1), Article e2453131. https://doi.org/10.1001/jamanetworkopen.2024.53131
Wang, X., Nursyifa, C., Aninta, S. G., Garcia-Erill, G., Bertola, L. D., Khan, A., Kuja, J., Hanghøj, K., Meisner, J., Bøggild, T., Bradshaw, C. J. A., Al-Chaer, A., Persada, A. P., Priyono, D. S., Tribudi, Y. A., Sudrajad, P., Gaina, C. D., Jiang, Y., Lenstra, J. A. ... Heller, R. (2025). The genetic diversity of Indonesian cattle has been shaped by multiple introductions and adaptive introgression. Nature Communications, 16(1), Article 8192. https://doi.org/10.1038/s41467-025-62692-z
Conover, C. A. & Oxvig, C. (2025). The IGF System and Aging. Endocrine Reviews, 46(2), 214-223. https://doi.org/10.1210/endrev/bnae029
Marzookian, K., Aliakbari, F., Hourfar, H., Sabouni, F., Otzen, D. E. & Morshedi, D. (2025). The neuroprotective effect of human umbilical cord MSCs-derived secretome against α-synuclein aggregates on the blood-brain barrier. International Journal of Biological Macromolecules, 304(Part 1), Article 140387. https://doi.org/10.1016/j.ijbiomac.2025.140387
Segur-Bailach, E., Mateu-Bosch, A., Bofill-De Ros, X., Parés, M., da Silva Buttkus, P., Rathkolb, B., Gailus-Durner, V., Hrabě de Angelis, M., Moeini, P., Gonzalez-Aseguinolaza, G., Tort, F., Ribes, A., van Karnebeek, C. D. M., García-Villoria, J. & Fillat, C. (2025). Therapeutic AASS inhibition by AAV-miRNA rescues glutaric aciduria type I severe phenotype in mice. Molecular Therapy, 33(10), 4820-4833. https://doi.org/10.1016/j.ymthe.2025.07.022
Poulsen, E. T., Nielsen, N. S. & Enghild, J. J. (2025). The role of the extracellular matrix in TGFBI-related corneal dystrophy development. In E. K. Kim & R. D. Stulting (Eds.), TGFBI-related Corneal Dystrophies: Clinical Findings, Cell Biology, and Genetics (pp. 77-94). Springer. https://doi.org/10.1007/978-981-96-0131-8_9
Shah, A., Zhang, X., Snee, M., Lockhart-Cairns, M. P., Levy, C. W., Jowitt, T. A., Birchenough, H. L., Dean, L., Collins, R., Dodd, R. J., Roberts, A. R. E., Enghild, J. J., Mantovani, A., Fontana, J., Baldock, C., Inforzato, A., Richter, R. P. & Day, A. J. (2025). The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix. Matrix biology : journal of the International Society for Matrix Biology, 136, 52-68. https://doi.org/10.1016/j.matbio.2025.01.002
O’Leary, E., Jiang, Y., Kristensen, L. S., Hansen, T. B. & Kjems, J. (2025). The therapeutic potential of circular RNAs. Nature Reviews Genetics, 26(4), 230-244. Article 2629. https://doi.org/10.1038/s41576-024-00806-x
McLain, A., Saffie-Siebert, S. R., Nielsen, N. S., Patterson, B., Scavenius, C., Enghild, J. J., Marshall, J., Baran-Rachwalska, P., Welsh, M., Sutera, F. M., Moore, L., Willoughby, C., Nesbit, M. A. & Moore, T. (2025). Topical mutant allele-specific siRNA delivery for treatment of Meesmann epithelial corneal dystrophy and elucidation of disease biomarkers. Journal of Controlled Release, 388, Article 114315. https://doi.org/10.1016/j.jconrel.2025.114315