Bale, L. K., Schafer, M. J., Atkinson, E. J., Le Brasseur, N. K., Haak, A. J.
, Oxvig, C. & Conover, C. A. (2022).
Pregnancy-associated plasma protein-A (PAPP-A) is a key component of an interactive cellular mechanism promoting pulmonary fibrosis.
Journal of Cellular Physiology,
237(4), 2220-2229.
https://doi.org/10.1002/jcp.30687
Antaki, D., Guevara, J., Maihofer, A. X., Klein, M., Gujral, M.
, Grove, J., Carey, C. E., Hong, O., Arranz, M. J., Hervas, A., Corsello, C., Vaux, K. K., Muotri, A. R., Iakoucheva, L. M., Courchesne, E., Pierce, K., Gleeson, J. G., Robinson, E. B., Nievergelt, C. M. & Sebat, J. (2022).
Publisher Correction: A phenotypic spectrum of autism is attributable to the combined effects of rare variants, polygenic risk and sex (Nature Genetics, (2022), 10.1038/s41588-022-01064-5).
Nature Genetics,
54(8), 1259.
https://doi.org/10.1038/s41588-022-01145-5
Gockert, M., Schmid, M., Jakobsen, L., Jens, M., Andersen, J. S.
& Jensen, T. H. (2022).
Rapid factor depletion highlights intricacies of nucleoplasmic RNA degradation.
Nucleic Acids Research,
50(3), 1583-1600.
https://doi.org/10.1093/nar/gkac001
Singh, T., Poterba, T., Curtis, D., Akil, H., Al Eissa, M., Barchas, J. D., Bass, N., Bigdeli, T. B., Breen, G., Bromet, E. J., Buckley, P. F., Bunney, W. E., Bybjerg-Grauholm, J., Byerley, W. F., Chapman, S. B., Chen, W. J., Churchhouse, C., Craddock, N., Cusick, C. M. ... Daly, M. J. (2022).
Rare coding variants in ten genes confer substantial risk for schizophrenia.
Nature,
604(7906), 509-516.
https://doi.org/10.1038/s41586-022-04556-w
Petersen, K. V., Tesauro, C., Hede, M. S.
, Pages, C., Marcussen, L. B., Keller, J. G., Bugge, M.
, Holm, K., Bjergbæk, L., Stougaard, M., Wejse, C. & Knudsen, B. R. (2022).
Rolling Circle Enhanced Detection of Specific Restriction Endonuclease Activities in Crude Cell Extracts.
Sensors,
22(20), Article 7763.
https://doi.org/10.3390/s22207763
Christensen, K. J.
, Dreier, J. W., Skotte, L., Feenstra, B.
, Grove, J., Børglum, A. D., Mitrovic, M., Cotsapas, C.
& Christensen, J. (2022).
Seasonal Variation and Risk of Febrile Seizures: A Danish Nationwide Cohort Study.
Neuroepidemiology,
56(2), 138-145.
https://doi.org/10.1159/000522065
Blokland, G. A. M.
, Grove, J., Chen, C. Y., Cotsapas, C., Tobet, S., Handa, R., Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium & iPSYCH (2022).
Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders.
Biological Psychiatry,
91(1), 102-117.
https://doi.org/10.1016/j.biopsych.2021.02.972
Murphy, K. M., Poretsky, E.
, Liu, H., Micic, N., Nyhuis, A., Bohlmann, J., Schmelz, E. A., Zerbe, P., Huffaker, A. & Bjarnholt, N. (2022).
Shielding the oil reserves: The scutellum as a source of chemical defenses.
Plant Physiology,
188(4), 1944-1949.
https://doi.org/10.1093/plphys/kiac038
Keller, J. G., Mizielinski, K.
, Petersen, K. V., Stougaard, M., Knudsen, B. R. & Tesauro, C. (2022).
Simple and Fast Rolling Circle Amplification-Based Detection of Topoisomerase 1 Activity in Crude Biological Samples.
Journal of visualized experiments : JoVE,
190, Article e64484.
https://doi.org/10.3791/64484
Teodori, L., Omer, M., Märcher, A., Skaanning, M. K., Andersen, V. L., Nielsen, J. S., Oldenburg, E., Lin, Y., Gothelf, K. V. & Kjems, J. (2022).
Site-specific nanobody-oligonucleotide conjugation for super-resolution imaging.
Journal of Biological Methods,
9(1), Article e159.
https://doi.org/10.14440/jbm.2022.381
Toth, A. E., Helms, H. C.
, Harazin, A., Johnsen, K. B., Goldeman, C., Burkhart, A., Thomsen, M. S., Kempen, P. J.
, Klepe, A., Lipka, D. V., Møller, P. L., Andresen, T. L.
, Nyegaard, M., Moos, T., Brodin, B.
& Nielsen, M. S. (2022).
Sortilin regulates blood-brain barrier integrity.
The FEBS Journal,
289(4), 1062-1079.
https://doi.org/10.1111/febs.16225
Matzke, M.
, Toft, S., Bechsgaard, J., Pold Vilstrup, A., Uhl, G., Künzel, S.
, Tuni, C. & Bilde, T. (2022).
Sperm competition intensity affects sperm precedence patterns in a polyandrous gift-giving spider.
Molecular Ecology,
31(8), 2435-2452.
https://doi.org/10.1111/mec.16405
Weiner, D. J., Ling, E., Erdin, S., Tai, D. J. C., Yadav, R.
, Grove, J., Fu, J. M., Nadig, A., Carey, C. E., Baya, N., Bybjerg-Grauholm, J., iPSYCH Consortium, ASD Working Group of the Psychiatric Genomics Consortium, ADHD Working Group of the Psychiatric Genomics Consortium, Berretta, S., Macosko, E. Z., Sebat, J., O'Connor, L. J., Hougaard, D. M. ... Robinson, E. B. (2022).
Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p.
Nature Genetics,
54(11), 1630-1639.
https://doi.org/10.1038/s41588-022-01203-y
Winkler, M. B. L., Nel, L., Frain, K. M., Dedic, E., Olesen, E. & Pedersen, B. P. (2022).
Sterol uptake by the NPC system in eukaryotes: a Saccharomyces cerevisiae perspective.
FEBS Letters,
596(2), 160-179.
https://doi.org/10.1002/1873-3468.14253
Sahin, C., Østerlund, E. C., Österlund, N., Costeira-Paulo, J.
, Pedersen, J. N., Christiansen, G.
, Nielsen, J., Grønnemose, A. L., Amstrup, S. K., Tiwari, M. K., Rao, R. S. P., Bjerrum, M. J., Ilag, L. L., Davies, M. J., Marklund, E. G.
, Pedersen, J. S., Landreh, M.
, Møller, I. M., Jørgensen, T. J. D.
& Otzen, D. E. (2022).
Structural Basis for Dityrosine-Mediated Inhibition of α-Synuclein Fibrillization.
Journal of the American Chemical Society,
144(27), 11949-11954.
https://doi.org/10.1021/jacs.2c03607
Jensen, R. K., Pedersen, H., Lorentzen, J., Laursen, N. S., Vorup-Jensen, T. & Andersen, G. R. (2022).
Structural insights into the function-modulating effects of nanobody binding to the integrin receptor αMβ2.
Journal of Biological Chemistry,
298(8), Article 102168.
https://doi.org/10.1016/j.jbc.2022.102168
Nielsen, J., Brandt, J.
, Boesen, T., Hummelshøj, T., Slaaby, R., Schluckebier, G.
& Nissen, P. (2022).
Structural investigations of full-length insulin receptor dynamics and signalling.
Journal of Molecular Biology,
434(5), Article 167458.
https://doi.org/10.1016/j.jmb.2022.167458
Bisiak, F., Chrenková, A., Zhang, S. D.
, Pedersen, J. N., Otzen, D. E., Zhang, Y. E.
& Brodersen, D. E. (2022).
Structural variations between small alarmone hydrolase dimers support different modes of regulation of the stringent response.
Journal of Biological Chemistry,
298(7), Article 102142.
https://doi.org/10.1016/j.jbc.2022.102142
Braunger, K., Ahn, J., Jore, M. M., Johnson, S., Tang, T. T. L.
, Pedersen, D. V., Andersen, G. R. & Lea, S. M. (2022).
Structure and function of a family of tick-derived complement inhibitors targeting properdin.
Nature Communications,
13, Article 317.
https://doi.org/10.1038/s41467-021-27920-2
Hartmann, S.
, Ling, M., Dreyer, L. S. A., Zipori, A.
, Finster, K., Grawe, S.
, Jensen, L. Z., Borck, S., Reicher, N., Niedermeier, D.
, Jones, N. C., Hoffmann, S. V., Wex, H., Rudich, Y.
, Boesen, T. & Santl-Temkiv, T. (2022).
Structure and Protein-Protein Interactions of Ice Nucleation Proteins Drive Their Activity.
Frontiers in Microbiology,
13, Article 872306.
https://doi.org/10.3389/fmicb.2022.872306
Gerlach, P.
, Garland, W., Lingaraju, M., Salerno-Kochan, A., Bonneau, F., Basquin, J.
, Jensen, T. H. & Conti, E. (2022).
Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome.
Molecular Cell,
82(13), 2505-2518.e7.
https://doi.org/10.1016/j.molcel.2022.04.011
Pedersen, H., Jensen, R. K., Hansen, A. G., Petersen, S. V., Thiel, S., Laursen, N. S. & Andersen, G. R. (2022).
Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity.
Frontiers in Immunology,
13, Article 872536.
https://doi.org/10.3389/fimmu.2022.872536
Langousis, G., Cavadini, S.
, Boegholm, N., Lorentzen, E., Kempf, G. & Matthias, P. (2022).
Structure of the ciliogenesis-associated CPLANE complex.
Science Advances,
8(15), Article eabn0832.
https://doi.org/10.1126/sciadv.abn0832
Kobberø, S. D., Gajhede, M., Mirza, O. A.
, Kløverpris, S., Kjær, T. R., Mikkelsen, J. H., Boesen, T. & Oxvig, C. (2022).
Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism.
Nature Communications,
13(1), Article 6084.
https://doi.org/10.1038/s41467-022-33698-8
Ung, K. L., Winkler, M., Schulz, L., Kolb, M., Janacek, D. P.
, Dedic, E., Stokes, D. L., Hammes, U. Z.
& Pedersen, B. P. (2022).
Structures and mechanism of the plant PIN-FORMED auxin transporter.
Nature,
609(7927), 605-610.
https://doi.org/10.1038/s41586-022-04883-y
Fuertes, M., Selas, A., Trejo, A.
, Knudsen, B. R., Palacios, F. & Alonso, C. (2022).
Synthesis of hybrid phosphorated indenoquinolines and biological evaluation as topoisomerase I inhibitors and antiproliferative agents.
Bioorganic and Medicinal Chemistry Letters,
57, Article 128517.
https://doi.org/10.1016/j.bmcl.2021.128517
Jakobsen, A. K., Yuusufi, S., Madsen, L. B., Meldgaard, P., Knudsen, B. R. & Stougaard, M. (2022).
TDP1 and TOP1 as targets in anticancer treatment of NSCLC: Activity and protein level in normal and tumor tissue from 150 NSCLC patients correlated to clinical data.
Lung Cancer,
164, 23-32.
https://doi.org/10.1016/j.lungcan.2021.12.010
Jakobsen, A-K., Yuusufi, S., Madsen, L. B., Meldgaard, P., Knudsen, B. R. & Stougaard, M. (2022).
TDP1 and TOP1 as targets in anticancer treatment of NSCLC: Activity and protein level in normal and tumor tissue from 150 NSCLC patients correlated to clinical data.
Lung Cancer,
164, 23-32.
https://doi.org/10.1016/j.lungcan.2021.12.010
Thodberg, K., Foldager, L., Fogsgaard, K. K., Gaillard, C. & Herskin, M. S. (2022).
Temperature conditions during commercial transportation of cull sows to slaughter.
Computers and Electronics in Agriculture,
192, Article 106626.
https://doi.org/10.1016/j.compag.2021.106626
Rasmussen, H. Ø., Wollenberg, D. T. W.
, Wang, H., Andersen, K. K., Oliveira, C. L. P., Jørgensen, C. I., Jørgensen, T. J. D.
, Otzen, D. E. & Pedersen, J. S. (2022).
The changing face of SDS denaturation: Complexes of Thermomyces lanuginosus lipase with SDS at pH 4.0, 6.0 and 8.0.
Journal of Colloid and Interface Science,
614, 214-232.
https://doi.org/10.1016/j.jcis.2021.12.188
Harwood, S. L., Diep, K., Nielsen, N. S., Jensen, K. T. & Enghild, J. J. (2022).
The conformational change of the protease inhibitor α2-macroglobulin is triggered by the retraction of the cleaved bait region from a central channel.
Journal of Biological Chemistry,
298(8), Article 102230.
https://doi.org/10.1016/j.jbc.2022.102230
Farzadfard, A., Pedersen, J. N., Meisl, G.
, Somavarapu, A. K., Alam, P., Goksøyr, L., Nielsen, M. A., Sander, A. F., Knowles, T. P. J.
, Pedersen, J. S. & Otzen, D. E. (2022).
The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization.
Communications Biology,
5(1), Article 123.
https://doi.org/10.1038/s42003-022-03059-8
Wigdor, E. M., Weiner, D. J.
, Grove, J., Fu, J. M.
, Thompson, W. K., Carey, C. E., Baya, N., van der Merwe, C., Walters, R. K., Satterstrom, F. K., Palmer, D. S., Rosengren, A., Bybjerg-Grauholm, J., Hougaard, D. M.
, Mortensen, P. B., Daly, M. J., Talkowski, M. E., Sanders, S. J., Bishop, S. L. ... iPSYCH Consortium (2022).
The female protective effect against autism spectrum disorder.
Cell Genomics,
2(6), Article 100134.
https://doi.org/10.1016/j.xgen.2022.100134
Mogensen, E. H., Poulsen, E. T., Thøgersen, I. B., Yamamoto, K.
, Brüel, A. & Enghild, J. J. (2022).
The low-density lipoprotein receptor-related protein 1 (LRP1) interactome in the human cornea.
Experimental Eye Research,
219, Article 109081.
https://doi.org/10.1016/j.exer.2022.109081
Bergeron, L. A.
, Besenbacher, S., Turner, T. N., Versoza, C. J., Wang, R. J., Price, A. L., Armstrong, E.
, Riera, M., Carlson, J., Chen, H. Y., Hahn, M. W., Harris, K.
, Kleppe, A. S., López-Nandam, E. H., Moorjani, P., Pfeifer, S. P., Tiley, G. P., Yoder, A. D., Zhang, G.
& Schierup, M. H. (2022).
The mutationathon highlights the importance of reaching standardization in estimates of pedigree-based germline mutation rates.
eLife,
11, Article e73577.
https://doi.org/10.7554/eLife.73577
Fruergaard, M. U., Dach, I., Andersen, J. L., Ozol, M., Shasavar, A., Quistgaard, E. M. H., Poulsen, H., Fedosova, N. & Nissen, P. (2022).
The Na,K-ATPase in complex with beryllium fluoride mimics an ATPase phosphorylated state. Journal of Biological Chemistry,
298(9), Article 102317.
https://doi.org/10.1016/j.jbc.2022.102317
Salimi, M., Tabasi, F.
, Nazari, M., Ghazvineh, S. & Raoufy, M. R. (2022).
The olfactory bulb coordinates the ventral hippocampus–medial prefrontal cortex circuit during spatial working memory performance.
Journal of Physiological Sciences,
72(1), Article 9.
https://doi.org/10.1186/s12576-022-00833-5
Frank, M., Cortleven, A., Pěnčík, A., Novak, O. & Schmülling, T. (2022).
The Photoperiod Stress Response in Arabidopsis thaliana Depends on Auxin Acting as an Antagonist to the Protectant Cytokinin.
International Journal of Molecular Sciences ,
23(6), Article 2936.
https://doi.org/10.3390/ijms23062936