Damages to DNA can accumulate with age, increasing the risk of serious diseases such as cancer and neurodegenerative disorders. Pablo Alcón and his upcoming research group will employ cryogenic electron microscopy (cryo-EM) to investigate proteins repairing these damages, aiming to understand their role in disease development, including Fanconi Anemia (FA), a rare hereditary disease associated with bone marrow failure and an increased cancer risk.
Their work aims to elucidate the molecular mechanisms behind the DNA repair system's function, which could potentially impact the development of new treatments for hereditary diseases and cancer.
