Department of Molecular Biology and Genetics

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 Department of Molecular Biology and Genetics Research Research areas Neurobiology Gilles Vanwalleghem

Gilles Vanwalleghem
[Translate to English:] Legend: The six days old larval zebrafish expresses a fluorescent calcium reporter in all of its neurons, including in the enteric nervous system that regulates the gut. We use this transparent animal to image in vivo the activity of its neurons. Arrows indicate the rostral, dorsal, caudal, and ventral directions. Scale bar is 100 um.
Video legend: Live imaging of the activity of neurons in the guts of a six days old larval zebrafish, we can see the high motility of the guts driven by the waves of neuronal activity.

Featured articles

  • “Brain-wide mapping of water flow perception in zebrafish.” Vanwalleghem G, Schuster K, Taylor MA, Favre-Bulle IA, Scott EK. Journal of Neuroscience, doi: 10.1523/JNEUROSCI.0049-20.2020 (2020)
  • “Cellular resolution imaging of vestibular processing across the larval zebrafish brain” Favre-Bulle IA*, Vanwalleghem GC*, Taylor MA, Rubinsztein-Dunlop H, Scott EK. Current Biology. doi: 10.1016/j.cub.2018.09.060. (2018)
  • “Integrative whole-brain neuroscience in larval zebrafish" Vanwalleghem G, Ahrens MB and Scott EK. Current Opinion in Neurobiology. doi: 10.1016/j.conb.2018.02.004 (2018)

Peer-reviewed publications

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Vanwalleghem, G., Fontaine, F., Lecordier, L., Tebabi, P., Klewe, K., Nolan, D. P., Yamaryo-Botté, Y., Botté, C., Kremer, A., Burkard, G. S., Rassow, J., Roditi, I., Pérez-Morga, D. & Pays, E. (2015). Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1. Nature Communications, 6, Article 8078. https://doi.org/10.1038/ncomms9078
Salmon, D., Vanwalleghem, G., Morias, Y., Denoeud, J., Krumbholz, C., Lhommé, F., Bachmaier, S., Kador, M., Gossmann, J., Dias, F. B. S., De Muylder, G., Uzureau, P., Magez, S., Moser, M., De Baetselier, P., Van Den Abbeele, J., Beschin, A., Boshart, M. & Pays, E. (2012). Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host. Science, 337(6093), 463-466. https://doi.org/10.1126/science.1222753
Hourez, R., Azdad, K., Vanwalleghem, G., Roussel, C., Gall, D. & Schiffmann, S. N. (2005). Activation of protein kinase C and inositol 1,4,5-triphosphate receptors antagonistically modulate voltage-gated sodium channels in striatal neurons. G E P, 1059(2), 189-196. https://doi.org/10.1016/j.brainres.2005.08.031

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Revised 13.11.2025