In a screening for a functional impact to the neuronal differentiation process, Danish researchers identified a specific circular RNA, circZNF827, which surprisingly “taps the brake” on neurogenesis. The results provide an interesting example of co-evolution of a circRNA, and its host-encoded protein product, that regulate each other’s function, to directly impact the fundamental process of neurogenesis.
Danish and Canadian researchers have uncovered important molecular details about the regulation of the cell biosynthesis-machinery during cellular stress. This knowledge has implications for anti-cancer treatment, since the implicated factors are key regulators of cell growth and proliferation.
Researchers at Aarhus University have revealed a previously unknown function of a cellular enzyme that can disperse toxic aggregates in the cells of patients with muscular dystrophy.
Researchers from Denmark and Poland have uncovered a novel molecular pathway, which regulates gene expression in the cytoplasm of human cells. The finding has implications for the human diseases; the Perlman syndrome of overgrowth and Wilms' tumor development.
In a joint effort, a researcher from Aarhus University and an American researcher have uncovered how a specific network of “messenger molecules” are inhibited simultaneously in the cell during cellular stress. These findings contribute to the understanding of how the cell regulates networks of genes during cellular stress and could eventually contribute to advancing our understanding of diseases where this type of regulation is not functioning properly.